Regulatory Non-Coding RNAs in Oncogenesis and Tumor Inhibition
A special issue of Non-Coding RNA (ISSN 2311-553X).
Deadline for manuscript submissions: closed (28 May 2019)
Special Issue Editors
Interests: non-coding RNA; epigenetics; biomarkers; thoracic malignancy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Current analyses of the human transcriptome indicate that a mere 2% of the genome corresponds to protein coding transcripts, yet it is estimated that ~70–90% of the genome is transcribed. Essentially, the majority of RNA transcribed is non-coding.
These non-coding RNAs (ncRNAs) are broadly divided into two categories according to their size: small ncRNAs, less than 200-nucleotides long, and long non-coding RNAs (lncRNAs), over 200-nucleotides long. Small ncRNAs include well-characterized types like tRNAs and rRNAs, as well as more recently discovered types such as microRNAs (miRNAs), small interfeering (siRNAs), small nucleolar RNAs (snoRNAs), small nuclear RNAs (snRNAs), and piwi-interacting RNAs (piRNAs). Most recently, a novel class of RNAs called circular RNA (circRNA) has been identified (some of which are non-coding).
Many of these ncRNAs play a variety of important cellular roles. Critically, aberrant expression of many ncRNAs is associated with cancer. Some, such as miRNAs, can affect the regulation of critical tumor suppressors through competitive endogenous RNA (ceRNA)-mediated effects. Others, such as circRNAs, can act as “molecular sponges” to limit miRNA availability and affect growth. Many ncRNAs also act to regulate processes such as epithelial-mesenchymal transition (EMT), a key element in oncogenesis.
The purpose of this Special Issue is to bring together a series of articles (both reviews and original research) related to these important non-coding RNAs with respect to their roles in cancer formation and development.
Dr. Steven G. Gray
Dr. John Aird
Dr. John Greene
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Non-Coding RNA is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cancer
- miRNA
- lncRNA
- circRNA
- ceRNA
- networks
