The Impact of Food Compounds on Obesity Mechanisms

A special issue of Obesities (ISSN 2673-4168).

Deadline for manuscript submissions: 30 November 2025 | Viewed by 1352

Special Issue Editor


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Guest Editor
Laboratory of Physiology and Metabolism, Department of Food Safety and Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture, Tokyo, Japan
Interests: nutrition; phytochemicals; lipids; nuclear receptors; lipid metabolisms; inflammation; insulin resistance; hyperlipidemia; adipocytes; hepatocytes; enterocytes
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Special Issue Information

Dear Colleagues,

In recent years, understanding the physiological functions of food-derived compounds has become essential for the management of metabolic disorders such as obesity and diabetes. Food-derived compounds act on various organs and/or tissues. To elucidate the mechanisms of their functions, it is necessary to conduct not only cell-based research, but also animal experiments. In particular, for studies on the physiological effects of food extracts, animal experiments are essential, as are cell-based experiments. This is because cells involved in the development of metabolic diseases such as adipocytes, hepatocytes, myocytes, and intestinal epithelial cells are metabolically linked. Therefore, this Special Issue welcomes the submission of a wide range of original and review articles focusing on the physiological effects of food-derived compounds and extracts on obesity-related metabolic disorders. However, animal experiments are required for the investigation of extracts.

Prof. Dr. Nobuyuki Takahashi
Guest Editor

Manuscript Submission Information

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Keywords

  • food compounds/extracts
  • obesity
  • diabetes
  • adipose tissue
  • adipocytes
  • nutritional metabolism
  • thermogenesis
  • myocytes
  • hepatocytes
  • inflammation
  • insulin sensitivity/resistance

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Published Papers (1 paper)

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Research

16 pages, 1228 KB  
Article
Supplementation Effects of Hibiscus sabdariffa L. Flower Aqueous Extract on Body Composition and Metabolism in Eutrophic and Obese Rats
by João Fernando Bernardo da Costa, Alana Louzada Millions Monteiro, Bruna Almeida Nascimento, Clarice Maia Vinagre de Oliveira, Karen Pereira Coutinho, Anderson Junger Teodoro, Barbara Elisabeth Teixeira-Costa and Mariana Sarto Figueiredo
Obesities 2025, 5(4), 67; https://doi.org/10.3390/obesities5040067 - 25 Sep 2025
Viewed by 796
Abstract
Obesity is a chronic, multifactorial disease characterized by excess body fat and is a major risk factor for various metabolic disorders. Bioactive compounds from the diet have been recognized for their role in preventing chronic non-communicable diseases and as adjuvants in managing endocrine–metabolic [...] Read more.
Obesity is a chronic, multifactorial disease characterized by excess body fat and is a major risk factor for various metabolic disorders. Bioactive compounds from the diet have been recognized for their role in preventing chronic non-communicable diseases and as adjuvants in managing endocrine–metabolic dysfunctions. Hibiscus sabdariffa L. (HSL) is rich in bioactive compounds with antioxidant, antihypertensive, and antihyperlipidemic properties. This study evaluated the effects of HSL flower extract supplementation on body composition, lipid profile, and biochemical parameters in both eutrophic and high-fat diet-induced obese rats. Thirty-two Wistar rats were assigned to four groups: control, control plus HSL extract, high-fat diet, and high-fat diet plus HSL extract. The extract was administered orally at 150 mg kg−1 for thirty days. Dual-energy X-ray absorptiometry revealed that HSL supplementation significantly attenuated fat mass gain (from 98 g to 75 g) and adiposity indices (10.23 to 8.86) in obese rats without altering total body mass. Moreover, the HSL extract improved lipid profiles by reducing LDL cholesterol from 23 to 13 mg dL−1 and exhibited potential hepatoprotective effects linked with decreased ALT (40 to 26.7 U L−1) and total bilirubin (0.12 to 0.07 mg dL−1) levels. Although glucose metabolism parameters had no significant differences, a trend toward improved insulin sensitivity was observed. These results suggest that the aqueous HSL extract may exert cardioprotective, hepatoprotective, and anti-obesity effects, supporting its potential as a complementary therapeutic agent in obesity and related metabolic disorders. Full article
(This article belongs to the Special Issue The Impact of Food Compounds on Obesity Mechanisms)
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