Genomic Epidemiology & Drug Resistance in Mycobacterium tuberculosis

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Bacterial Pathogens".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 568

Special Issue Editors


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Guest Editor
Department of Biochemistry & Molecular Biology, Catholic University of Health and Allied Sciences, Mwanza, Tanzania
Interests: pathogen genomics

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Guest Editor
Genomics Laboratory, Department of Molecular Biology and Immunology, School of Biomedical Sciences, Makerere University College of Health Sciences, Kampala, Uganda
Interests: virulence genes

Special Issue Information

Dear Colleagues,

Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), remains a leading cause of morbidity and mortality worldwide. The growing threat of drug-resistant TB poses significant challenges to global TB control efforts. Recent advances in genomic epidemiology and bioinformatics have significantly enhanced our understanding of Mtb transmission dynamics, resistance mechanisms, and the evolution of drug-resistant strains. This Special Issue welcomes original research, reviews, and methodological articles focused on molecular surveillance, whole-genome sequencing, and resistance profiling of M. tuberculosis. We particularly encourage submissions leveraging data science and machine learning to integrate genomic, clinical, and epidemiological data for improved diagnostics, treatment strategies, and public health responses. The findings from this collection aim to inform innovative solutions for TB control and resistance mitigation globally.

Dr. Benson Kidenya
Dr. Gerald Mboowa
Guest Editors

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Keywords

  • Mycobacterium tuberculosis
  • genomic epidemiology
  • drug resistance
  • whole genome sequencing
  • machine learning
  • data science
  • antimicrobial resistance (AMR)

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Published Papers (1 paper)

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Review

19 pages, 1450 KB  
Review
Reimagining Tuberculosis Control in the Era of Genomics: The Case for Global Investment in Mycobacterium tuberculosis Genomic Surveillance
by Gerald Mboowa
Pathogens 2025, 14(10), 975; https://doi.org/10.3390/pathogens14100975 - 26 Sep 2025
Viewed by 450
Abstract
Drug-resistant Mycobacterium tuberculosis remains a significant global public health threat. While whole-genome sequencing (WGS) holds immense promise for understanding transmission dynamics and drug resistance mechanisms, its integration into routine surveillance remains limited. Additionally, insights from WGS are increasingly contributing to vaccine discovery by [...] Read more.
Drug-resistant Mycobacterium tuberculosis remains a significant global public health threat. While whole-genome sequencing (WGS) holds immense promise for understanding transmission dynamics and drug resistance mechanisms, its integration into routine surveillance remains limited. Additionally, insights from WGS are increasingly contributing to vaccine discovery by identifying novel antigenic targets and understanding pathogen evolution. The COVID-19 pandemic catalyzed an unprecedented expansion of genomic capacity in many low- and middle-income countries (LMICs), with public health institutions acquiring next-generation sequencing (NGS) platforms and developing local expertise in real-time pathogen surveillance. This hard-won capacity now represents a transformative opportunity to accelerate TB control enabling rapid detection of drug-resistant strains and high-resolution mapping of transmission networks that are critical for timely, targeted interventions. Furthermore, the integration of machine learning with genomic and clinical data offers a powerful avenue to improve the prediction of drug resistance and to tailor patient-specific TB management strategies. This article examines the practical challenges, emerging opportunities, and policy considerations necessary to embed genomic epidemiology within national TB control programs, particularly in high-burden, resource-constrained settings. Full article
(This article belongs to the Special Issue Genomic Epidemiology & Drug Resistance in Mycobacterium tuberculosis)
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