Pathogenic Escherichia coli: Mechanisms of Virulence, Antimicrobial Resistance and Public Health Implications

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Bacterial Pathogens".

Deadline for manuscript submissions: 15 December 2025 | Viewed by 799

Special Issue Editor


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Guest Editor
Department of Obstetrics and Gynecology, UT Medical Branch at Galveston, Galveston, TX 77555, USA
Interests: Escherichia coli; urinary tract infection; chronic sinusitis
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Special Issue Information

Dear Colleagues,

Pathogenic Escherichia coli (E. coli) strains are a leading cause of gastrointestinal and extraintestinal infections worldwide, posing significant public health challenges. These strains are classified into several pathotypes, including enterotoxigenic E. coli (ETEC), enterohemorrhagic E. coli (EHEC), and uropathogenic E. coli (UPEC), each with distinct virulence mechanisms and clinical manifestations. This special issue explores the molecular basis of E. coli pathogenicity, focusing on adhesion factors, toxins, and immune evasion strategies. The role of antimicrobial resistance in complicating treatment and the emergence of multidrug-resistant strains are also discussed. Additionally, the special issue highlights the importance of surveillance, rapid diagnostic tools, and preventive measures, such as improved sanitation and vaccine development, in controlling E. coli infections. Understanding the diversity and adaptability of pathogenic E. coli is crucial for developing effective interventions and mitigating their impact on global health.

In addition to already stated subjects, we would especially welcome manuscripts that focus on chronic and recurrent UTIs.

Dr. Bogdan Nowicki
Guest Editor

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Keywords

  • pathogenic Escherichia coli
  • virulence factors
  • antimicrobial resistance
  • gastrointestinal infections
  • public health

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Published Papers (1 paper)

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Review

19 pages, 4039 KB  
Review
Role of Uropathogenic Escherichia coli and Other Pathogens in Kidney Stone Formation: From Pathogenesis to Treatment
by Beata Zalewska-Piątek, Michalina Nagórka and Rafał Piątek
Pathogens 2025, 14(10), 991; https://doi.org/10.3390/pathogens14100991 - 1 Oct 2025
Viewed by 528
Abstract
Urinary tract infections (UTIs) are among the most prevalent infections in the human population. Uropathogenic Escherichia coli, the primary causative agent of UTIs, may also contribute to the development of metabolic kidney stones, particularly those composed of calcium oxalate. Kidney stone disease [...] Read more.
Urinary tract infections (UTIs) are among the most prevalent infections in the human population. Uropathogenic Escherichia coli, the primary causative agent of UTIs, may also contribute to the development of metabolic kidney stones, particularly those composed of calcium oxalate. Kidney stone disease (KSD), known as nephrolithiasis or urolithiasis, is one of the most common disorders of the urinary system. This review explores the significant clinical association between UTIs and kidney stones, focusing on the mechanisms by which UPEC may promote stone formation, including oxidative stress, inflammation, and altered citrate metabolism. It also examines the role of immune responses, particularly macrophage activity, in the progression of KSD. Recent evidence suggests that the composition of the gut microbiota and metabolic imbalances have an additional impact on stone development. In light of these findings, current prevention and treatment strategies, including microbiota-targeted therapies, probiotics, and immune modulation, are also reviewed. Understanding the complex links between UTI, immunity, and metabolism provide new insights into the pathogenesis of KSD and allows for the development of more effective treatments for this disease. Full article
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