New Insights on Gut Microbiota and Diseases
A special issue of Pathogens (ISSN 2076-0817).
Deadline for manuscript submissions: closed (20 February 2024) | Viewed by 257
Special Issue Editors
Interests: gut microbiota; infection and immunity; metabolism
Special Issue Information
Dear Colleagues,
A community of commensal, symbiotic, and pathogenic microorganisms colonize the gut, termed gut microbiota which include viruses, bacteria, microeukaryotes, and archaea. The gut microbiota is now recognized as one of the important elements in regulating host health. Changes in the composition of gut microbiota which can be induced by diet, the environment, or infection are not only linked to local gut diseases, but also extra-gastrointestinal diseases. Dysbiosis perturbs the normal communication between the gut and distant organs, which can contribute to diseases. However, limited information on the causes of dysbiosis and the causative effects of dysbiosis on disease makes it difficult to translate research into medical interventions. It has been suggested that metabolite is an important factor impacting the host’s immune system, such as short-chain fatty acids, secondary bile acids, and amino acid. Identifying a disease-associated microbe and its metabolite on local and systemic immune microenvironments and understanding the molecular mechanisms of metabolite impacting on the immune metabolism of immune or non-immune cells will advance our understanding on the complexity and the molecular aspects linking gut microbiota to health. These aspects of the gut microbiota–diseases relationship will be discussed here, and these findings will help to set the basis for precision therapeutic interventions.
Prof. Dr. Yongguo Cao
Dr. Guanhong Wang
Guest Editors
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Keywords
- gut microbiota
- dysbiosis
- metabolite
- immune metabolism
- gut–distant organs axis
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