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Pathogens
Special Issues
Updates on Animal Papillomaviruses
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Updates on Animal Papillomaviruses

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Viral Pathogens".

Deadline for manuscript submissions: 20 June 2025 | Viewed by 2368

Special Issue Editors

Dr. Francesca De Falco

E-Mail Website
Guest Editor
Dipartimento di Medicina Veterinaria e Produzioni Animali, Università degli Studi di Napoli Federico II, 80137 Napoli, Italy
Interests: molecular biology; papillomavirus; ddPCR
Prof. Dr. Franco Roperto

E-Mail Website
Guest Editor
Dipartimento di Biologia, Università degli Studi di Napoli Federico II, 80136 Napoli, Italy
Interests: autophagy; mitophagy; papillomavirus

Special Issue Information

Dear Colleagues,

Papillomavirus are oncogenic double-strand DNA viruses and induce benign hyperplastic lesions of skin tissues and mucous membranes in their various hosts, including many domestic and wild animals and humans. There are some papillomavirus genotypes that can infect hosts other than their own. The main focus in this Special Issue is the study of many papillomavirus and the assessment of interactions between high-risk papillomavirus oncoproteins and programmed cell-death pathways. I appeal to all members of this community to submit numerous articles that, among other things, will provide a summary of researchers working in the field of papillomavirus biology. I hope that readers of these articles will find them useful to make our community a reality, thus strengthening an open exchange of ideas that will help stimulate our scientific curiosity. I look forward to our community helping to launch a very interesting Special Issue. Please feel free to contact any other colleagues you think can contribute.

Dr. Francesca De Falco
Prof. Dr. Franco Roperto
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • papillomavirus
  • trans-species transmission
  • environmental contamination

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Published Papers (2 papers)

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15 pages, 4033 KiB  
Article
Vertical Intrauterine Bovine and Ovine Papillomavirus Coinfection in Pregnant Cows
by Francesca De Falco, Anna Cutarelli, Leonardo Leonardi, Ioan Marcus and Sante Roperto
Pathogens 2024, 13(6), 453; https://doi.org/10.3390/pathogens13060453 - 26 May 2024
Viewed by 1116
Abstract
There is very little information available about transplacental infections by the papillomavirus in ruminants. However, recent evidence has emerged of the first report of vertical infections of bovine papillomavirus (BPV) in fetuses from naturally infected, pregnant cows. This study reports the coinfection of [...] Read more.
There is very little information available about transplacental infections by the papillomavirus in ruminants. However, recent evidence has emerged of the first report of vertical infections of bovine papillomavirus (BPV) in fetuses from naturally infected, pregnant cows. This study reports the coinfection of BPV and ovine papillomavirus (OaPV) in bovine fetuses from infected pregnant cows suffering from bladder tumors caused by simultaneous, persistent viral infections. Some molecular mechanisms involving the binary complex composed of Eras and platelet-derived growth factor β receptor (PDGFβR), by which BPVs and OaPVs contribute to reproductive disorders, have been investigated. A droplet digital polymerase chain reaction (ddPCR) was used to detect and quantify the nucleic acids of the BPVs of the Deltapapillomavirus genus (BPV1, BPV2, BPV13, and BPV14) and OaPVs belonging to the Deltapapillomavirus (OaPV1, OaPV2, and OaPV4) and Dyokappapapillomavirus (OaPV3) genera in the placenta and fetal organs (heart, lung, liver, and kidneys) of four bovine fetuses from four pregnant cows with neoplasia of the urinary bladder. A papillomaviral evaluation was also performed on the bladder tumors and peripheral blood of these pregnant cows. In all fetal and maternal samples, the genotype distribution of BPVs and OaPVs were evaluated using both their DNA and RNA. A BPV and OaPV coinfection was seen in bladder tumors, whereas only BPV infection was found in peripheral blood. The genotype distribution of both the BPVs and OaPVs detected in placentas and fetal organs indicated a stronger concordance with the viral genotypes detected in bladder tumors rather than in peripheral blood. This suggests that the viruses found in placentas and fetuses may have originated from infected bladders. Our study highlights the likelihood of vertical infections with BPVs and OaPVs and emphasizes the importance of gaining further insights into the mechanisms and consequences of this exposure. This study warrants further research as adverse pregnancy outcomes are a major source of economic losses in cattle breeding. Full article
(This article belongs to the Special Issue Updates on Animal Papillomaviruses)
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7 pages, 1490 KiB  
Case Report
Histopathological and Virological Findings of a Penile Papilloma in a Japanese Stallion with Equus Caballus Papillomavirus 2 (EcPV2)
by Eri Uchida-Fujii, Yusei Kato, Takanori Ueno, Yasuko Numasawa, Shigeki Yusa and Takeshi Haga
Pathogens 2024, 13(7), 597; https://doi.org/10.3390/pathogens13070597 - 19 Jul 2024
Viewed by 863
Abstract
Equus caballus papillomavirus 2 (EcPV2) is known to cause genital neoplasms in horses. However, reports on EcPV2 in Japan and Asia are limited. Herein, we present the histopathological and virological findings of the first reported case of an EcPV2-associated penile mass in Japan. [...] Read more.
Equus caballus papillomavirus 2 (EcPV2) is known to cause genital neoplasms in horses. However, reports on EcPV2 in Japan and Asia are limited. Herein, we present the histopathological and virological findings of the first reported case of an EcPV2-associated penile mass in Japan. The patient was a 22-year-old stallion with a history of breeding in Japan and abroad. Histopathological examination contained RNA in situ hybridization targeting the E6/E7 region and an immunohistochemical approach, and whole-genome sequencing was conducted within the viral examination. Proliferating epidermal cells were observed, and EcPV2 E6/E7 mRNA was detected within the epidermis, which was interpreted as viral papilloma. The detected EcPV2 virus was genetically close to foreign strains and different from the strain previously reported from a Japanese mare. This suggests that various types of EcPV2 might already exist among horses in Japan. Although the mass reported herein was not malignant based on histopathological findings and the absence of recurrence, its presence on the penis would be an obstacle to breeding. These results provide a better understanding of the pathogenesis and diversity of EcPV2. Full article
(This article belongs to the Special Issue Updates on Animal Papillomaviruses)
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