Understanding Microbial Keratitis: Basic Science, Epidemiology, Diagnosis and Management

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Epidemiology of Infectious Diseases".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 622

Special Issue Editors


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1. Liverpool Hospital, Sydney 2170, Australia
2. Faculty of Medicine and Health, The University of Sydney, Sydney 2006, Australia
3. Translational Ocular Research and Immunology Consortium (TORIC), Westmead Institute for Medical Research, Sydney 2145, Australia
Interests: ophthalmology

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Faculty of Medicine, UNSW, Kensington, Australia
Interests: ophthalmology; retinal; vitreoretinal

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School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, Australia
Interests: cell biology; ocular immunology; neuroimmune crosstalk; neuroinflammation; neuropathic pain; stem cells

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Guest Editor
Save Sight Institute, University of Sydney, City Road, Camperdown, NSW 2050, Australia
Interests: ophthalmology

Special Issue Information

Dear Colleagues,

Microbial keratitis (MK) is a serious and sight-threatening ocular emergency that requires prompt diagnosis and intensive topical antimicrobial therapy to salvage vision. It is caused by a variety of organisms that can be broadly categorized as bacteria, fungi, viruses and protozoa, and is likely to occur in the context of a compromised epithelial layer. The cornea is especially vulnerable to microbial infection due to its avascular nature, and poor visual outcomes may result from a lack of aggressive, targeted antimicrobial therapy. Prompt diagnosis and treatment are crucial for the management of MK. Empirical treatment is based on the probability and likelihood of the causative organism in the geographical location. This emphasizes the crucial role that microbial surveillance plays in the treatment of MK and the importance of ongoing monitoring of resistance patterns to help establish effective empirical antimicrobial treatment. Further, MK often requires hospital admission for intensive topical antimicrobial therapy and is associated with a greater economic burden to patients, healthcare and society.

The current Special Issue invites research articles (clinical and basic science), reviews, editorials and comments on contemporary hot topics in the field of microbial keratitis. The purpose is to improve our understanding of microbial keratitis and make positive contributions to the protection of corneal health.

Dr. Chameen Samarawickrama
Dr. Vannessa Leung
Dr. Yashar Seyed Razavi
Dr. Samantha Bobba
Guest Editors

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Published Papers (1 paper)

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Research

12 pages, 1685 KiB  
Article
Direct Cost Analysis of Microbial Keratitis in North China: A Hospital-Based Retrospective Study
by Qingquan Shi, Bo Peng, Zhen Cheng, Zijun Zhang, Zhenyu Wei, Zhiqun Wang, Yang Zhang, Kexin Chen, Xizhan Xu, Xinxin Lu, Kai Cao, Xueyao Wei and Qingfeng Liang
Pathogens 2024, 13(8), 666; https://doi.org/10.3390/pathogens13080666 - 7 Aug 2024
Viewed by 368
Abstract
Microbial keratitis (MK) is the fourth leading cause of blindness globally, imposing a substantial burden on the healthcare system. This study aims to determine the cost composition of MK patients and explore factors influencing these expenses. We analyzed the demographics, clinical features, and [...] Read more.
Microbial keratitis (MK) is the fourth leading cause of blindness globally, imposing a substantial burden on the healthcare system. This study aims to determine the cost composition of MK patients and explore factors influencing these expenses. We analyzed the demographics, clinical features, and costs of 602 MK patients treated at Beijing Tongren Hospital from June 2021 to October 2023. The analysis revealed the average total cost of treating MK was USD 1646.8, with a median of USD 550.3 (IQR: 333.3–1239.1). Patients with Acanthamoeba keratitis (AK) incurred the highest median total costs at USD 706.2 (IQR: 399.2–3370.2). Additionally, AK patients faced the highest costs for ophthalmic exams and laboratory tests (both p < 0.001), while patients with fungal keratitis (FK) and viral keratitis (VK) experienced higher medication costs. Costs varied significantly with the severity of MK, especially for outpatients at severity level 4, which was markedly higher than levels 1–3 (USD 1520.1 vs. USD 401.0, p < 0.001). Delayed presentation also resulted in increased costs (USD 385.2 vs. USD 600.3, p < 0.001). Our study highlights the financial burden associated with MK treatment and underscores the importance of timely and accurate diagnosis and intervention. Full article
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