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Pathogens
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Molecular Pathogenesis and Vaccine Development of Porcine Virus Infection
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Molecular Pathogenesis and Vaccine Development of Porcine Virus Infection

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Vaccines and Therapeutic Developments".

Deadline for manuscript submissions: closed (20 May 2024) | Viewed by 5973

Special Issue Editors

Dr. Chia-Yi Chang

E-Mail Website
Guest Editor
School of Veterinary Medicine, National Taiwan University, No.1, Sec. 4, Roosevelt Rd., Taipei 10617, Taiwan
Interests: pestiviruses; virulence; pathogenesis; viral glycoprotein structure and function; epitope mapping
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Fun-In Wang

E-Mail Website
Guest Editor
School of Veterinary Medicine, National Taiwan University, No.1, Sec. 4, Roosevelt Rd., Taipei 10617, Taiwan
Interests: veterinary pathology; diagnostic pathology; pathogenesis of viral diseases and of swine diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, more and more endemic and emerging porcine viral diseases have spread throughout the world, causing huge economic impact on swine production. Important porcine viral diseases include African swine fever (ASF), classical swine fever (CSF), foot and mouth disease (FMD), porcine epidemic diarrhea (PED), porcine reproductive and respiratory syndrome (PRRS), and porcine circovirus associated disease (PCVAD). Vaccines are available against several porcine viral diseases, such as CSF, FMD, PRRS, and PCV2, but there is no officially licensed vaccine available for ASF. This Special Issue of Pathogens will focus on the Molecular Pathogenesis and Vaccine Development of Porcine Viral Diseases. After experiencing the impact of these viral diseases in the form of the COVID-19 pandemic, it has become clear that a precise understanding of viral pathogenesis lays a solid foundation for the development of efficacious vaccines. Thus, the two issues of molecular pathogenesis and vaccine development are in fact one.

Suggested topics for including in this Special Issue include, but are not limited to, pathogenesis in vitro and in vivo, virulence factors, host immune response, identification of potential viral antigens, new techniques for vaccine development and production, and the development of DIVA vaccines. We would like to cordially invite you to contribute your papers to this Special Issue. There is no limitation on the types of contributions; original articles, brief communications, case reports, and reviews are welcome. Your valuable input will enrich the current state of knowledge and contribute to the disease control of porcine virus infections.

Dr. Chia-Yi Chang
Prof. Dr. Fun-In Wang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pathogenesis
  • virulence
  • immune response
  • vaccine development
  • porcine virus

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Published Papers (2 papers)

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Research

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19 pages, 4502 KiB  
Article
Label-Free Detection of African Swine Fever and Classical Swine Fever in the Point-of-Care Setting Using Photonic Integrated Circuits Integrated in a Microfluidic Device
by Georgios Manessis, Maciej Frant, Katarzyna Podgórska, Anna Gal-Cisoń, Magdalena Łyjak, Kinga Urbaniak, Grzegorz Woźniakowski, Lilla Denes, Gyula Balka, Lapo Nannucci, Amadeu Griol, Sergio Peransi, Zoitsa Basdagianni, Christos Mourouzis, Alessandro Giusti and Ioannis Bossis
Pathogens 2024, 13(5), 415; https://doi.org/10.3390/pathogens13050415 - 16 May 2024
Cited by 1 | Viewed by 1766
Abstract
Swine viral diseases have the capacity to cause significant losses and affect the sector’s sustainability, a situation further exacerbated by the lack of antiviral drugs and the limited availability of effective vaccines. In this context, a novel point-of-care (POC) diagnostic device incorporating photonic [...] Read more.
Swine viral diseases have the capacity to cause significant losses and affect the sector’s sustainability, a situation further exacerbated by the lack of antiviral drugs and the limited availability of effective vaccines. In this context, a novel point-of-care (POC) diagnostic device incorporating photonic integrated circuits (PICs), microfluidics and information, and communication technology into a single platform was developed for the field diagnosis of African swine fever (ASF) and classical swine fever (CSF). The device targets viral particles and has been validated using oral fluid and serum samples. Sensitivity, specificity, accuracy, precision, positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR) were calculated to assess the performance of the device, and PCR was the reference method employed. Its sensitivities were 80.97% and 79%, specificities were 88.46% and 79.07%, and DOR values were 32.25 and 14.21 for ASF and CSF, respectively. The proposed POC device and PIC sensors can be employed for the pen-side detection of ASF and CSF, thus introducing novel technological advancements in the field of animal diagnostics. The need for proper validation studies of POC devices is highlighted to optimize animal biosecurity. Full article
(This article belongs to the Special Issue Molecular Pathogenesis and Vaccine Development of Porcine Virus Infection)
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Review

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18 pages, 3288 KiB  
Review
The Effects of Swine Coronaviruses on ER Stress, Autophagy, Apoptosis, and Alterations in Cell Morphology
by Ya-Mei Chen and Eric Burrough
Pathogens 2022, 11(8), 940; https://doi.org/10.3390/pathogens11080940 - 19 Aug 2022
Cited by 10 | Viewed by 3598
Abstract
Swine coronaviruses include the following six members, namely porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV), porcine delta coronavirus (PDCoV), swine acute diarrhea syndrome coronavirus (SADS-CoV), porcine hemagglutinating encephalomyelitis virus (PHEV), and porcine respiratory coronavirus (PRCV). Clinically, PEDV, TGEV, PDCoV, and SADS-CoV [...] Read more.
Swine coronaviruses include the following six members, namely porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV), porcine delta coronavirus (PDCoV), swine acute diarrhea syndrome coronavirus (SADS-CoV), porcine hemagglutinating encephalomyelitis virus (PHEV), and porcine respiratory coronavirus (PRCV). Clinically, PEDV, TGEV, PDCoV, and SADS-CoV cause enteritis, whereas PHEV induces encephalomyelitis, and PRCV causes respiratory disease. Years of studies reveal that swine coronaviruses replicate in the cellular cytoplasm exerting a wide variety of effects on cells. Some of these effects are particularly pertinent to cell pathology, including endoplasmic reticulum (ER) stress, unfolded protein response (UPR), autophagy, and apoptosis. In addition, swine coronaviruses are able to induce cellular changes, such as cytoskeletal rearrangement, alterations of junctional complexes, and epithelial-mesenchymal transition (EMT), that render enterocytes unable to absorb nutrients normally, resulting in the loss of water, ions, and protein into the intestinal lumen. This review aims to describe the cellular changes in swine coronavirus-infected cells and to aid in understanding the pathogenesis of swine coronavirus infections. This review also explores how the virus exerted subcellular and molecular changes culminating in the clinical and pathological findings observed in the field. Full article
(This article belongs to the Special Issue Molecular Pathogenesis and Vaccine Development of Porcine Virus Infection)
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