Persistent COVID-19 on CNS: A Consequence of an Infection or a Persistent Quiescent Infection?
A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Viral Pathogens".
Deadline for manuscript submissions: closed (15 October 2022) | Viewed by 6216
Special Issue Editors
Interests: multiple sclerosis; neurodegenerative diseases; neural repair; neuromolecular mechanisms; long COVID
Special Issues, Collections and Topics in MDPI journals
Interests: ALS; MS; cerebrovascular pathologies; stroke
Special Issues, Collections and Topics in MDPI journals
Interests: Alzheimer disease; neurodegenerative diseases; cognition; cognitive post-COVID-19 disease; neuroimaging
Special Issues, Collections and Topics in MDPI journals
Interests: neural repair; stem cells therapy; biomaterials; experimental models; central nervous system
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
A Delphy study carried out within the framework of the WHO has recently established the criteria to define prolonged clinical conditions after infection by SARS-Cov2. These clinical syndromes have received different names such as post-COVID-19 syndrome, persistent COVID-19, or long COVID. These conditions predominately show symptoms that are associated with the CNS, such as headache, fatigue, or cognitive alterations.
Different studies have analyzed the potential presence of SARS-Cov2 in the CNS, especially discussing the routes of entry. However, the information on whether the virus or its RNA can persist is much less, although it is known that various types of coronavirus have been found in the brain of patients who have presented multiple sclerosis or neurological diseases.
The debate is still open on whether the brain can be a reservoir of the virus, and whether this can be more evident in those subjects who have presented a lower discharge of inflammatory cytokines. Likewise, whether the presence of the virus or its RNA can predispose to neurodegenerative diseases has also been suggested.
Knowing whether patients with persistent COVID-19 or long COVID are the consequence of an acute infection or due to the persistence of the virus in a inactive state is an unanswered question with implications on many aspects.
This Special Issue aims for authors and researchers to participate in this debate with contributions both in the form of opinions and articles that show evidence that leads to a better understanding of the mechanisms that sustain persistent COVID-19 in its relationship with the CNS.
Dr. Jorge Matias-Guiu
Dr. Ulises Gomez‐Pinedo
Dr. Jordi A. Matias-Guiu
Dr. Alejandro Arturo Canales-Aguirre
Dr. Alberto Delgado-Iribarren
Guest Editors
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Keywords
- SARS-Cov2
- persistent COVID-19 diseases
- long COVID
- central nervous system
- persistent infection
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