Histamine Receptors: Ligand Design, Pharmacology, and Therapeutic Applications
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmacology".
Deadline for manuscript submissions: 25 May 2026
Special Issue Editors
Interests: medicinal chemistry; drug discovery; organic synthesis; heterocyclic synthesis; multi-target ligands; histamine; H3 ligands; H1 ligands; guinea pig ex vivo assay
Special Issues, Collections and Topics in MDPI journals
Interests: medicinal chemistry; drug discovery; organic synthesis; heterocyclic synthesis; multi-target ligands; histamine; H3 ligands; H1 ligands; guinea pig ex vivo assay
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Histamine receptors are one of the most studied G protein-coupled receptors (GPCRs) and play crucial roles in various physiological and pathophysiological conditions, including allergic reactions (H1R), gastric acid secretion (H2R), cognitive functions, and CNS disorders, by modulating histamine and other neurotransmitter release (H3R) or inflammatory conditions (H4R). Furthermore, multi-target directed ligands (MTDLs) have become a significant target for diseases with complex pathogenesis.
This Special Issue aims to discuss cutting-edge advancements in research on histamine receptors and the role of new biologically active agents in novel therapeutic strategies, thereby expanding the knowledge of medicinal chemistry. We would like to publish studies that contribute to ligand design, synthesis, and understanding of the relationship between structure and activity (SAR), mode of action, and therapeutic applications. We encourage scientists to share both original and computational results of their research, as well as comprehensive reviews and short communications concerning histamine receptors and their ligands in this Special Issue. Furthermore, we believe that our Special Issue will inspire the scientific community worldwide. The subtopics may include a wide range of topics, but are not limited to the following:
- Design, synthesis, and structural modification of histamine receptor ligands;
- SAR of the histamine ligands;
- Target-based drug discovery;
- Pharmacological or pharmacokinetic evaluation of novel potent lead compounds and biologically active molecules;
- Alternative therapeutics: novelty and hopes;
- Multifunctional histamine receptor ligands in medicinal chemistry;
- Molecular mechanisms underlying the pharmacological actions of histamine ligands;
- Computational studies of histamine ligands that provide insight into the SAR of the novel molecules.
Dr. Marek Staszewski
Prof. Dr. Krzysztof Walczyński
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- Histamine receptors
- Drug discovery
- Ligand design
- Antagonist/inverse agonist
- Pharmacology
- Therapeutic Applications
- Multi-target directed ligands
- Molecular modeling
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