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Pharmaceuticals publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Application of 2D and 3D-QSAR Models in Drug Design

edited by

Jaime Mella Raipan

submission deadline 22 Apr 2025 | 9 articles | Viewed by 11411

Keywords: 2D-QSAR; 3D-QSAR; Hansch analysis; Free– Wilson; structure-activity relationships; CoMFA; CoMSIA; drug design; molecular docking; molecular dynamics.

(This special issue belongs to the Section Medicinal Chemistry)

Use of Encapsulating Polymers of Active Compounds in the Pharmaceutical Industry

edited by Alba Adriana Vallejo-Cardona, Inocencio Higuera-Ciapara and

Janna Douda

submission deadline 22 Apr 2025 | Viewed by 531

Keywords: polymer; drug delivery; active compounds; encapsulation; pharmaceutical industry; natural polymers; synthetic polymers

(This special issue belongs to the Section Pharmaceutical Technology)

Pluripotent Stem Cell for Novel Drug Discovery

edited by Kevin G. Chen

submission deadline 22 Apr 2025 | Viewed by 453

Keywords: Pluripotent stem cells; disease modeling; 2D-monolayer culture; 3D tissues; Organoids; drug discovery; drug development

(This special issue belongs to the Section Biopharmaceuticals)

Medicinal Potential of Cannabidiol and New Structural Analogs

edited by

Patricia Fernandes

submission deadline 23 Apr 2025 | Viewed by 213 | Submission Open

Keywords: cancer; inflammation; pain; analgesia; cannabidiol; parkinson disease; huntington disease; alzheimer disease

(This special issue belongs to the Section Medicinal Chemistry)

Application of Supercritical Fluids in Pharmaceutical Science

edited by

Cecília I. A. V. Santos

submission deadline 23 Apr 2025 | Viewed by 174 | Submission Open

Keywords: supercritical fluids; scCO2; drug formulation; bioavailability; green chemistry; drug delivery systems; nanoparticle encapsulation; bioactive compound extraction; pharmaceutical purification; controlled release; sustainable pharmaceutical processes

(This special issue belongs to the Section Pharmaceutical Technology)

Drug Candidates for Allergic Diseases

edited by

Luis Manuel Teran

submission deadline 25 Apr 2025 | 9 articles | Viewed by 29997 | Submission Open

Keywords: allergic disease; asthma; CRSwNP; atopic dermatitis; biologicals; chronic urticaria; pharmacology; novel drugs

(This special issue belongs to the Section Pharmacology)

Plant-Derived Nanotherapeutics and Nanocarriers: Recent Progress and Future Directions

edited by

Estefânia V.R. Campos

and

Jhones Luiz De Oliveira

submission deadline 25 Apr 2025 | 9 articles | Viewed by 26367 | Submission Open

Keywords: plant-based nanomaterials; green nanomaterials; drug delivery; natural nanotherapeutics; pharmaceutical nanoformulations; biogenic synthesis; phytonanotechnology

(This special issue belongs to the Section Pharmaceutical Technology)

The 20th Anniversary of Pharmaceuticals—Advances in Pharmacology

edited by

Gary J. Stephens

submission deadline 25 Apr 2025 | 11 articles | Viewed by 19301 | Submission Open

Keywords: behavioral pharmacology; cancer pharmacology; cardiovascular pharmacology; chronopharmacology; clinical pharmacology; immunopharmacology; molecular and biochemical pharmacology; neuropharmacology; pharmacoepidemiology; pharmacogenetics/pharmacogenomics; pharmacokinetics; systems pharmacology; toxicology; translational pharmacology/medicine; safety pharmacology

(This special issue belongs to the Section Pharmacology)

Infectious Disease Epidemiology and Pharmaceutical Development

edited by Victoria Birlutiu,

Simin Aysel Florescu

and Oana Săndulescu

submission deadline 25 Apr 2025 | 8 articles | Viewed by 15835 | Submission Open

Keywords: viral infections; bacterial infections; healthcare-associated infections; tropical diseases; epidemiology of infectious diseases; antibiotic resistance; vaccination; epidemiology of bone and joint infections

(This special issue belongs to the Section Pharmacology)

Pyrazole and Thiazole Derivatives in Medicinal Chemistry

edited by

Dimitris Matiadis

Antonella Messore

and

Nicolas Primas

submission deadline 25 Apr 2025 | 9 articles | Viewed by 14112 | Submission Open

(This special issue belongs to the Section Medicinal Chemistry)

Bioactive Compounds From Plants and Their Therapeutic Applications in Lifestyle-Related Diseases

edited by

Syota Kagawa

and

Agnieszka Ludwiczuk

submission deadline 25 Apr 2025 | 5 articles | Viewed by 10729 | Submission Open

Keywords: natural compounds; lifestyle-related diseases; pharmacology; molecular mechanisms; clinical applications

(This special issue belongs to the Section Natural Products)

Bioactive Compounds and Their Optimized Structural Derivatives of Natural Products

edited by Yanhua Fan and Shuzhen Mu

submission deadline 25 Apr 2025 | 5 articles | Viewed by 9169 | Submission Open

Keywords: natural products; bioactive compounds and their derivatives; isolation and purification; synthesis; structural modification or optimization; biological evaluation; mechanistic investigations; an evaluation of ADMET properties

(This special issue belongs to the Section Natural Products)

Pharmacology and Toxicology of Opioids

edited by

Juliana Faria

, Joana Barbosa and

Ricardo Dinis-Oliveira

submission deadline 25 Apr 2025 | 4 articles | Viewed by 7930 | Submission Open

Keywords: opioid toxicity; opioid pharmacodynamics; opioid pharmacokinetics; opioid pharmacogenetics; prescription opioids; toxicity assays; in vivo; in vitro; abuse; dependence

(This special issue belongs to the Section Pharmacology)

Toxicological Effects of Drug Abuse and Its Consequences on Health

edited by

Cristiane S. F. Maia

Enéas A. Fontes-Júnior

and

Rafael R. Lima

submission deadline 25 Apr 2025 | 3 articles | Viewed by 7472 | Submission Open

Keywords: addiction; drug abuse; toxicology; treatment; bioactive compound

(This special issue belongs to the Section Pharmacology)

Evaluation of the Antitumor Mechanism of Armed Antibodies: 2nd Edition

edited by

Yoshikatsu Koga

Hiroki Takashima

and

Ryo Tsumura

submission deadline 25 Apr 2025 | 3 articles | Viewed by 7202 | Submission Open

Keywords: antibody drug conjugate (ADC); photoimmunotherapy (PIT); radioimmunotherapy (RIT); antibody; conjugated nanoparticle; bispecific antibody; CAR-T cell therapy

(This special issue belongs to the Section Biopharmaceuticals)

Discovery of Novel Antidepressants and Anxiolytics

edited by James Oluwagbamigbe Fajemiroye and Gunnar P. H. Dietz

submission deadline 25 Apr 2025 | 5 articles | Viewed by 6741 | Submission Open

Keywords: biomarkers; depression; anxiety; anxiolytics; antidepressants; preclinical or clinical overview; experimental data; adverse effects; pharmacotherapy options; novel drugs

(This special issue belongs to the Section Pharmacology)

Oncolytic Viruses: New Cancer Immunotherapy Drugs

edited by Nikolas T. Martin

submission deadline 25 Apr 2025 | 3 articles | Viewed by 6431 | Submission Open

(This special issue belongs to the Section Pharmacology)

Solubilization and Controlled Release Strategy of Poorly Water-Soluble Drugs 2024

edited by

María Ángeles Peña Fernández

submission deadline 25 Apr 2025 | 3 articles | Viewed by 5696 | Submission Open

Keywords: drug formulation; solubilization; controlled release systems; solubility; poor water-soluble drugs

(This special issue belongs to the Section Pharmaceutical Technology)

Design and Synthesis of Small Molecule Kinase Inhibitors

edited by

Camilla Pecoraro

and

Daniela Carbone

submission deadline 25 Apr 2025 | 2 articles | Viewed by 5150 | Submission Open

Keywords: protein kinases; cancer; small molecule kinase inhibitors; heterocyclic compounds; cancer resistance; targeted therapy; cancer-altered pathway; genetic mutations; FDA-approved kinase inhibitors; kinase inhibitors combinations

(This special issue belongs to the Section Medicinal Chemistry)

The 20th Anniversary of Pharmaceuticals: Advances in Peptide Drug Design and Development: From Sequences to Drug Candidates

edited by Juliana C. C. Dallagnol and David Chatenet

submission deadline 25 Apr 2025 | 1 articles | Viewed by 3843 | Submission Open

Keywords: peptide-based drugs; drug design; therapeutic peptides; peptide synthesis; structure– activity relationship; peptide drug delivery; bioavailability; formulation strategies; peptide therapeutics

(This special issue belongs to the Section Biopharmaceuticals)

Synthetic Inhibitors of Nucleoside Monophosphate-Kinases

edited by

Mihaela Ileana Ionescu

Ovidiu Oniga

and

Cristina Nastasă

submission deadline 25 Apr 2025 | 1 articles | Viewed by 3283 | Submission Open

Keywords: nucleoside monophosphate-kinases; adenylate kinase; urydilate kinase; tymidilate kinase; guanilate kinase; cytidilate kinase; natural inhibitors; enzymatic activity; drug design; structural studies

(This special issue belongs to the Section Medicinal Chemistry)

In Vivo Nuclear Molecular Imaging in Drug Development and Pharmacological Research: New Advances

edited by Haitao Wu and

Noriko Sato

submission deadline 25 Apr 2025 | 3 articles | Viewed by 3099 | Submission Open

Keywords: in vivo nuclear imaging; biomarker imaging; molecular imaging; PET; SPECT; pharmacokinetics; personalized medicine; drug development; molecular pathway

(This special issue belongs to the Section Radiopharmaceutical Sciences)

Targeting The Nuclear Factor Kappa-B (NF-κB) Pathway for Drug Discovery

edited by Guozhou Xu

submission deadline 25 Apr 2025 | 1 articles | Viewed by 1693 | Submission Open

Keywords: NF-κ B; TNFR; TLR; IL1R; receptor adaptor proteins; IRAK; c-IAP; AKT IKK; ubiquitin-proteasome system; inflammatory response

(This special issue belongs to the Section Medicinal Chemistry)

Natural Products in Drug Discovery in the 21st Century: Challenges and Opportunities

edited by

Noelia Duarte

submission deadline 25 Apr 2025 | Viewed by 629 | Submission Open

Keywords: natural products; bioactive natural compounds; marine drugs; medicinal plants; in vitro and in vivo biological activity; pharmacological activity; drug discovery; medicinal and technological applications; medicinal chemistry

(This special issue belongs to the Section Natural Products)

Production, Development and Theranostic Applications of Radiopharmaceuticals for Nuclear Medicine

edited by Vlad Ghizdovat, Cipriana Stefanescu and Cécile Philippe

submission deadline 25 Apr 2025 | Viewed by 450 | Submission Open

Keywords: theranostic; radiopharmaceuticals; nuclear medicine; alpha-emitting radioisotopes; beta-emitting radioisotopes; gamma-emitting radioisotopes

(This special issue belongs to the Section Radiopharmaceutical Sciences)

New Development in Pharmacotherapy of Kidney Diseases

edited by Chihchao Yang

submission deadline 25 Apr 2025 | Viewed by 219 | Submission Open

Keywords: chronic kidney disease (CKD); acute kidney injury (AKI); pharmacotherapy; cardiovascular protection; kidney protection; bone health; endocrine function; gut health; metabolism; neuromuscular function; nutrition; symptom management; sodium-glucose cotransporter-2 (SGLT-2) inhibitors; glucagon-like peptide-1 (GLP-1) receptor agonists; non-steroidal mineralocorticoid receptor antagonists (MRA); endothelin receptor antagonists; anemia management; electrolyte abnormalities; dialysis; nephrotoxicity; drug interactions; uremic toxin; clinical trials; innovative therapies; protein-energy wasting; chronic kidney disease and bone mineral disease; inflammation; oxidation; diabetes; hypertension; obesity; hyperlipidemia; pruritus; osteoporosis; fracture; sarcopenia; protein-energy wasting

(This special issue belongs to the Section Pharmacology)

Pharmacotherapy of Dyslipidemias, 2nd Edition

edited by

Daniel Dias Rufino Arcanjo

and

Maria do Carmo de Carvalho e Martins

submission deadline 25 Apr 2025 | 1 articles | Viewed by 185 | Submission Open

Keywords: atherosclerosis; dyslipidemia; endothelial dysfunction; fatty acids; high-fat diet; hyperlipidemia; hypertriglyceridemia; polyunsaturated fatty acids; PUFA; statins

(This special issue belongs to the Section Medicinal Chemistry)

New and Emerging Treatment Strategies for Gastrointestinal Diseases

edited by

Daniele Maria-Ferreira

submission deadline 30 Apr 2025 | 5 articles | Viewed by 10294 | Submission Open

Keywords: gastrointestinal diseases; gastrointestinal homeostasis; gastrointestinal injuries; gastrointestinal disturbances; dysbiosis; bile acid; inflammatory bowel diseases; diarrhea

(This special issue belongs to the Section Pharmacology)

Development of Antibacterial Drugs to Combat Drug-Resistant Bacteria

edited by

Adriána Liptáková

submission deadline 30 Apr 2025 | 6 articles | Viewed by 10175 | Submission Open

Keywords: development of antibacterial drugs; drug-resistant bacteria; antimicrobial resistance; new therapeutic solutions; improvement of existing therapies; nosocomial infections

(This special issue belongs to the Section Pharmacology)

The 20th Anniversary of Pharmaceuticals—Heterocyclic Compounds and Their Application in Therapy

edited by

Thierry Besson

and

Pascal Marchand

submission deadline 30 Apr 2025 | 1 articles | Viewed by 3089 | Submission Open

(This special issue belongs to the Section Medicinal Chemistry)

Chalcones: Structure, Function, and Applications

edited by

Thomas Mavromoustakos

submission deadline 30 Apr 2025 | 1 articles | Viewed by 1256 | Submission Open

Keywords: chalcones; flavonoids; medicinal chemistry

(This special issue belongs to the Section Medicinal Chemistry)

Therapeutic Applications of Micro-RNA in Cancer Management

edited by

Alma D. Campos-Parra

submission deadline 30 Apr 2025 | 1 articles | Viewed by 759 | Submission Open

Keywords: cancer; miRNAs; therapeutic applications; miRNA treatments

(This special issue belongs to the Section Biopharmaceuticals)

β-Lactams and β-Lactamase Inhibitors: Recent Advances

edited by

Juan Carlos Vázquez-Ucha

submission deadline 30 Apr 2025 | Viewed by 394 | Submission Open

Keywords: beta-lactam; beta-lactamase inhibitors; antimicrobial resistance; beta-lactamase

(This special issue belongs to the Section Medicinal Chemistry)

Recent Advances in Stomach and Intestinal Drug Delivery Systems

edited by

Agustin Rascon-Chu

submission deadline 30 Apr 2025 | Viewed by 385 | Submission Open

Keywords: stomach delivery; intestinal delivery; meso– nanostructured carriers; micro– nanoparticles/capsules; permeability enhancement; stability; absorption enhancement; gut delivery

(This special issue belongs to the Section Pharmaceutical Technology)

Application of Biosensors in Pharmaceutical Research

edited by

Vasileios Tsekouras

and

Sofia Mavrikou

submission deadline 30 Apr 2025 | Viewed by 188 | Submission Open

Keywords: biosensors; diagnostics; high-throughput screening of pharmaceuticals; pharmaceutical analysis; point-of-care systems; drug discovery; drug analysis

(This special issue belongs to the Section Pharmaceutical Technology)

Past, Present and Future Radiotracer Techniques: Radiopharmaceuticals in Cancer Theranostics

edited by

Ute Hennrich

and

Martina Benešová-Schäfer

submission deadline 15 May 2025 | 10 articles | Viewed by 17618 | Submission Open

Keywords: diagnostic radiotracers; therapeutic radiopharmaceuticals; theranostics; radiolabeling techniques; GMP compliance; automated synthesis and quality control; pre-clinical studies; translation into clinics and first-in-human studies; clinical trials; regulatory approval

(This special issue belongs to the Section Radiopharmaceutical Sciences)

Cell Therapy for Cardiac Disease

edited by

Daniela Malan

and

Giulia Querio

submission deadline 15 May 2025 | 2 articles | Viewed by 5638 | Submission Open

Keywords: cell therapy; cardiac disease; stem cells; induced pluripotent stem cells (iPSCs); embryonic stem cells (ESCs); mesenchymal stem cells (MSCs); cardiac progenitor cells (CPCs); myocardial infarction; heart failure; regenerative medicine; cardiovascular regeneration; drug screening; personalized medicine; cell differentiation; cell delivery; clinical trials

(This special issue belongs to the Section Biopharmaceuticals)

Interaction between Nanoparticles and Antibiotics：Against Antimicrobial Resistance

edited by

Isabella Macário Ferro Cavalcanti

and Maria Carolina Accioly Brelaz de Castro

submission deadline 20 May 2025 | 3 articles | Viewed by 8990 | Submission Open

Keywords: microorganisms; resistance; pharmaceutical research; nanotechnology

Polymorphs, Salts, Cocrystals and Cationic Lipid Nanoparticle Complexes in Drug Delivery

edited by

Stephen Robert Byrn

submission deadline 20 May 2025 | 4 articles | Viewed by 6867 | Submission Open

(This special issue belongs to the Section Pharmaceutical Technology)

Mitochondrial Protease ClpP in Antitumor-Drug Development: Recent Advances and Challenges

edited by

Maria Grazia Perrone

and

Morena Miciaccia

submission deadline 20 May 2025 | Viewed by 654 | Submission Open

Keywords: caseinolytic peptidase P (ClpP); mitochondrial protein quality control; small molecules as targeted drugs; cancer therapy; high-grade glioma; breast cancer; prostate adenocarcinoma; hematological malignancies; bladder cancer; ovarian cancer

(This special issue belongs to the Section Medicinal Chemistry)

Nanotechnology in Biomedical Applications

edited by

Luciano Paulino Silva

submission deadline 20 May 2025 | 2 articles | Viewed by 537 | Submission Open

Keywords: nanotechnology; nanobiotechnology; biomedical applications; drug delivery; nanobiosensors; targeted therapy; diagnostics; nanomaterials; therapeutics; theranostics

(This special issue belongs to the Section Pharmaceutical Technology)

Biosimilars Development Strategies

edited by

Sarfaraz K. Niazi

and Sesselja S. Ómarsdóttir

submission deadline 20 May 2025 | 1 articles | Viewed by 465 | Submission Open

Keywords: biosimilars; generic medicines; drug development; biosimilar development

(This special issue belongs to the Section Medicinal Chemistry)

Design, Synthesis and Biological Assessment of Amphiphiles

edited by

Renata Odžak

and

Matilda Šprung

submission deadline 20 May 2025 | Viewed by 238 | Submission Open

Keywords: amphiphilic compounds; structure– activity relationship; biological potential

(This special issue belongs to the Section Medicinal Chemistry)

Antiplatelet Therapy in Inflammatory Diseases

edited by

Patricia Pia Wadowski

submission deadline 20 May 2025 | Viewed by 122 | Submission Open

Keywords: atherosclerotic diseases; inflammatory diseases; antiplatelet therapy; platelet inhibition

(This special issue belongs to the Section Biopharmaceuticals)

Medicinal Plants: Current Insights into Their Biological Activities and Integration with Micro- or Nanotechnologies

edited by

Jorge L. Mejía Méndez

Gildardo Sanchez-Ante

and

Edgar R. López-Mena

submission deadline 22 May 2025 | 1 articles | Viewed by 2297 | Submission Open

Keywords: medicinal plants; plant extracts; bioactive nanomaterials; inorganic materials; organic materials; drug delivery systems

Pharmacology of Heart Failure

edited by

Wioletta Szczurek-Wasilewicz

and

Bożena Szyguła-Jurkiewicz

submission deadline 23 May 2025 | 1 articles | Viewed by 2016 | Submission Open

Keywords: heart failure; pharmacological treatment; drug interactions; side effect; comorbidities

(This special issue belongs to the Section Pharmacology)

Gut Microbiota Modulation: Probiotics, Postbiotics and other Bioactive Compounds

edited by

Inês Brandão

and

Christophe Ruis Espírito Santo

submission deadline 25 May 2025 | 8 articles | Viewed by 37000 | Submission Open

Keywords: gut microbiota; bioactive compounds; immune system; nutrition respiratory health

(This special issue belongs to the Section Natural Products)

Drug Candidates for the Treatment of Oral Cancer and Oral Cancer Pain

edited by

Cara B. Gonzales

submission deadline 25 May 2025 | 9 articles | Viewed by 26295 | Submission Open

Keywords: oral cancer; oral cancer pain; drug discovery; natural compounds; immunotherapy; small molecule inhibitors; biomarkers

(This special issue belongs to the Section Medicinal Chemistry)

20th Anniversary of Pharmaceuticals—Therapeutic Mechanisms of Nature Products against Insulin Resistance

edited by

Anne-Dominique Lajoix

and

Didier Tousch

submission deadline 25 May 2025 | 4 articles | Viewed by 21021 | Submission Open

Keywords: insulin resistance; signaling pathways; liver; skeletal muscle; adipose tissues; traditional medicine; plants; fungus; algae; food ingredients

(This special issue belongs to the Section Natural Products)

Therapeutic Agents for the Treatment of Tumors in the CNS

edited by

Gautham Gampa

Sani H. Kizilbash

and

Shannon P. Fortin Ensign

submission deadline 25 May 2025 | 7 articles | Viewed by 13954 | Submission Open

Keywords: primary brain tumors; glioblastoma; brain metastases (BMs); neuro-oncology; blood– brain barrier (BBB); drug delivery; preclinical PK/PD; molecularly targeted agents; immunotherapy; new modalities

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