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Pharmaceuticals publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Antifungal Therapy Strategies: A Focus on Novel Compounds and Inhibitors

edited by

Lucimar Ferreira Kneipp

and

André Luis Souza dos Santos

submission deadline 30 Jun 2026 | 2 articles | Viewed by 1603 | Submission Open

Keywords: medicinal chemistry; combined therapy; antivirulence action; anti-resistance strategies; drug repositioning; drug delivery; multi-omics technologies

(This special issue belongs to the Section Medicinal Chemistry)

Novel Drug Candidates for the Treatment of Cardiac and Renal Diseases

edited by

Ana Karina Aranda-Rivera

José Pedraza Chaverri

and Diana Barrera-Oviedo

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1540 | Submission Open

Keywords: kidney diseases; cardiac diseases; cardiorenal syndrome; treatments; chronic kidney diseases; drugs; dyslipidemia; oxidative stress

(This special issue belongs to the Section Pharmacology)

Selected Papers from the 1st International Electronic Conference on Medicinal Chemistry and Pharmaceutics (ECMC-P2025)

edited by

Alfredo Berzal-Herranz

Patrick J. Sinko

and

Maria Emília De Sousa

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1514 | Submission Open

Keywords: small molecules as drug candidates; biomolecules; natural products; phages; and cells as therapeutic tools; biological targets and biomarkers; radiopharmaceutical sciences; radiochemistry; (hybrid) imaging; and nuclear medicine; nanotechnology; pharmacokinetics and pharmacodynamics; pharmaceutical preparations and drug delivery

(This special issue belongs to the Section Medicinal Chemistry)

Pharmacovigilance in Drug Therapy and Adverse Reactions

edited by

Jaime Conceição

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1509 | Submission Open

Keywords: pharmacovigilance; adverse reactions; drug safety; artificial intelligence; biological drugs; high-impact diseases

(This special issue belongs to the Section Pharmacology)

Advances in Analytical Method Development for Pharmaceutical Formulations

edited by

Michail Lykouras

and

Malvina Orkoula

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1441 | Submission Open

Keywords: pharmaceutical analysis; sample preparation; chromatographic techniques; solid-state characterization; particle size determination; vibrational spectroscopy; X-ray diffraction; thermal techniques; microscopy

(This special issue belongs to the Section Pharmaceutical Technology)

Drugs and Implants in Orthopedic Surgery and Traumatology

edited by

Ioannis Stratos

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1035 | Submission Open

Keywords: drug– device combinations; orthopedic and trauma implants; local drug delivery; periprosthetic joint infection (PJI); biofilm prevention; antimicrobial coatings; antibiotic‑loaded bone cement; release kinetics (PK/PD); bioresorbable implants; fracture healing and bone regeneration

(This special issue belongs to the Section Pharmaceutical Technology)

Curcumin: Current Status and Future Challenges in Drug Delivery and Advanced Formulations

edited by

Valentina Paganini

and

Silvia Tampucci

submission deadline 30 Jun 2026 | 1 articles | Viewed by 664 | Submission Open

Keywords: curcumin; curcumin delivery; curcumin formulations; therapeutic potential; natural polyphenols; phytochemicals; nanotechnology; pharmacological properties

(This special issue belongs to the Section Pharmacology)

Advances in Ocular Drug Delivery: Emerging Technologies for the Anterior Segment

edited by Raquel Gil-Cazorla and Affiong Iyire

submission deadline 30 Jun 2026 | 1 articles | Viewed by 547 | Submission Open

Keywords: ocular drug delivery; anterior segment; sustained-release systems; nanotechnology; novel delivery platforms

(This special issue belongs to the Section Pharmaceutical Technology)

Ferroptosis in Cancer and Beyond: Mechanisms, Biomarkers, and Interventions

edited by Hareesh B. Nair

submission deadline 30 Jun 2026 | Viewed by 486 | Submission Open

Keywords: ferroptosis therapeutics; GPX4/FSP1 axis; lipid peroxidation biomarkers; cancer and tissue protection; translational/clinical development

(This special issue belongs to the Section Pharmacology)

Drug Development and Emerging Pharmacotherapies in Stroke Management

edited by Federica Ferrari and

Pengyu Zong

submission deadline 30 Jun 2026 | Viewed by 455 | Submission Open

Keywords: brain ischemic stroke; cerebral hemorrhage; drug discovery; neuroprotection; immunomodulation; blood– brain barrier; drug delivery; biomarkers; neurorepair; post-stroke depression/dementia/spasticity

(This special issue belongs to the Section Pharmacology)

Optimizing Immunotherapeutic Strategies for Hematologic Malignancies

edited by

Erin Alexis Dean

, Victoria S. Brown and Dina Khalaf

submission deadline 30 Jun 2026 | Viewed by 379 | Submission Open

Keywords: lymphoma; multiple myeloma; leukemia; CAR T-cell therapy; NK cell therapy; autologous; allogeneic; bridging therapy; vein-to-vein time; safety switch; bispecific antibodies

(This special issue belongs to the Section Pharmacology)

The Potential Role of Natural Bioactive Compounds in the Protection of Renal Function

edited by

Giulia Marrone

submission deadline 30 Jun 2026 | Viewed by 337 | Submission Open

Keywords: natural bioactive compounds; renal health; oxidative stress; healthspan extension; chronic kidney disease; chronic non-communicable diseases; decline in renal function; biological pathways

(This special issue belongs to the Section Natural Products)

Cell Death, Mitochondrial Metabolism and Cancer Immunotherapy

edited by

Guang Lei

submission deadline 30 Jun 2026 | Viewed by 297 | Submission Open

Keywords: regulated cell death; mitochondrial metabolism; cancer metabolism; cancer immunotherapy; tumor suppressor pathways

(This special issue belongs to the Section Pharmacology)

Novel Bioactive Compounds Targeting Urinary Tract Disorders

edited by

Priscila de Souza

submission deadline 30 Jun 2026 | Viewed by 283 | Submission Open

Keywords: bioactive compounds; urinary tract disorders; nephroprotective agents; urolithiasis therapy; pharmacotherapy

(This special issue belongs to the Section Natural Products)

Polysulfide Pharmacology: Biological Effects and Therapeutic Potential in Pain, Inflammation, and CNS Disorders

edited by Gábor Pozsgai

submission deadline 30 Jun 2026 | Viewed by 280 | Submission Open

Keywords: polysulfides; organic polysulfide derivatives; polysulfide pharmacology; polysulfide biology

(This special issue belongs to the Section Pharmacology)

Hormone Signaling in Cardioprotection and Regeneration

edited by

Polyxeni D. Mantzouratou

and

Domenico Cerullo

submission deadline 30 Jun 2026 | Viewed by 274 | Submission Open

Keywords: cardiac regeneration; cardiac repair; heart failure; myocardial cell proliferation; hormone signaling; thyroid hormone; polyploidization; cell cycle

(This special issue belongs to the Section Pharmacology)

Natural Coumarins as Lead Compounds and Their Synthetic Analogues with Biological Activities: 2nd Edition

edited by

Anita Kornicka

and

Łukasz Balewski

submission deadline 30 Jun 2026 | Viewed by 231 | Submission Open

Keywords: coumarin; coumarin derivatives; natural products; synthesis; biological activity; drug discovery; drug candidates

(This special issue belongs to the Section Natural Products)

Pharmacological Targeting of Immune Checkpoints and Regulatory Pathways

edited by Monika Ducceschi and

Stefano Cavalieri

submission deadline 30 Jun 2026 | Viewed by 206 | Submission Open

Keywords: immunotherapy; immune-regulatory pathways; cancer; precision medicine; mechanism of resistance; predictive biomarkers; patient selection; immune-related adverse events

(This special issue belongs to the Section Pharmacology)

Antibody-Functionalized Nanomedicines for Targeted Therapy

edited by Pie Huda and

Craig A. Bell

submission deadline 30 Jun 2026 | Viewed by 205 | Submission Open

Keywords: antibody– drug conjugates; antibody fragments; nanomedicine; radiotherapy; RNA/DNA delivery systems; theranostics; immunotherapy; targeted drug delivery

(This special issue belongs to the Section Pharmaceutical Technology)

Pharmacotherapy of Endometriosis

edited by

Jang-Kyung Park

, Dong Il Kim and

Soo-Hyun Sung

submission deadline 1 Jul 2026 | 4 articles | Viewed by 32599 | Submission Open

Keywords: endometriosis; pharmacotherapy; integrative medicine; herbal medicine herbal formulations; plant-based compounds; herbal extracts; pharmacopuncture; pelvic pain; infertility

(This special issue belongs to the Section Pharmacology)

Recent Advances in Cancer Diagnosis and Therapy

edited by

Adriana Grigoraș

and

Hsin-Sheng Yang

submission deadline 5 Jul 2026 | 7 articles | Viewed by 17429 | Submission Open

Keywords: early diagnosis; advanced therapy; biomarkers; immunohistochemistry; molecular diagnosis; metastasis; prognosis; targeted therapies; combination therapies; cancer pharmacology

(This special issue belongs to the Section Pharmacology)

Current Trends to Discover New Drugs Targeting Protease Inhibition

edited by

Ricardo Olímpio de Moura

João Augusto Oshiro Júnior

and

Igor José dos Santos Nascimento

submission deadline 15 Jul 2026 | 3 articles | Viewed by 8131 | Submission Open

Keywords: protease inhibitors; target-based drug design (TBDD); computer-aided drug design (CADD); drug development; neglected diseases

(This special issue belongs to the Section Medicinal Chemistry)

Gene Delivery and Its Application in Pharmaceutical Science

edited by Xuanyu Chen and Wen Xiao

submission deadline 15 Jul 2026 | Viewed by 331 | Submission Open

Keywords: microRNAs; neuronal reprogramming; gene therapy; adeno-associated virus; neurodegenerative diseases; brain injury; spinal cord injury; tumor

(This special issue belongs to the Section Pharmaceutical Technology)

Redox-Active Natural Compounds in Metabolic and Inflammatory Diseases: Pharmacological Potential and Limitations

edited by

Mateusz Mołoń

and

Sabina Galiniak

submission deadline 15 Jul 2026 | Viewed by 265 | Submission Open

Keywords: redox-active natural compounds; oxidative stress modulation; metabolic diseases; inflammation; antioxidant pharmacology; bioactive phytochemicals

(This special issue belongs to the Section Natural Products)

Pharmacologically Active Compounds from Plants

edited by Duc Dat Le and

Cao Van Anh

submission deadline 20 Jul 2026 | 5 articles | Viewed by 21328 | Submission Open

Keywords: herbal medicines; bioactive compounds; NMR; phytochemistry; analytical method

(This special issue belongs to the Section Natural Products)

Natural Products for Skin Applications

edited by

Octavia Gligor

and

Ana-Maria Vlase

submission deadline 20 Jul 2026 | 8 articles | Viewed by 14189 | Submission Open

Keywords: bioactive compounds; plant extracts; topic preparations; skincare; cutaneous applications; skin cancer; medicinal plants; modern extraction techniques; optimized/standardized extracts; phytochemical analysis; health outcomes of plant extracts; bioaccessability of compounds from various vegetal matrices; drug– vegetal extract interactions at metabolic level

(This special issue belongs to the Section Natural Products)

Radiopharmaceuticals in Cancer Disorders: Clinical and Pharmaceutical Perspectives

edited by

Marta Rusek

submission deadline 20 Jul 2026 | 3 articles | Viewed by 4890 | Submission Open

Keywords: radiopharmaceuticals; cancer theranostics; targeted radionuclide therapy; molecular imaging; pharmaceutical development

(This special issue belongs to the Section Radiopharmaceutical Sciences)

Design, Synthesis and Biological Evaluation of Small Molecules for the Treatment of Solid Tumors

edited by

Aleksandra Sochacka-Ćwikła

Małgorzata Strzelecka

and

Żaneta Czyżnikowska

submission deadline 20 Jul 2026 | 1 articles | Viewed by 1227 | Submission Open

Keywords: anticancer drugs; small-molecule agents; targeted therapy; solid cancers; drug delivery systems; drug resistance; approval characteristic; FDA; EMA

(This special issue belongs to the Section Medicinal Chemistry)

Advances in Antibody–Drug Conjugates

edited by

Aiko Yamaguchi

submission deadline 20 Jul 2026 | 1 articles | Viewed by 927 | Submission Open

Keywords: antibody– drug conjugates; linker technology; bispecific antibodies; conditionally activated antibodies; degrader– antibody conjugates; antibody– immunotoxin conjugates; antibody– radionuclide conjugates; oncology; autoimmune disease; infectious disease

(This special issue belongs to the Section Pharmacology)

Dopamine Receptor: Novel Opportunities for Drug Developments

edited by Pegi Pavletić and

Fabio Del Bello

submission deadline 20 Jul 2026 | Viewed by 429 | Submission Open

Keywords: dopamine receptors (DRs); GPCR; drug discovery; in silico drug design; drug optimization; molecular modelling; targeted protein degradation; DMPK; neurological disorders; cancer

(This special issue belongs to the Section Medicinal Chemistry)

Pharmaceutical Excipients in Formulation Design and Drug Delivery: 2nd Edition

edited by

Beverley D. Glass

submission deadline 24 Jul 2026 | 1 articles | Viewed by 1364 | Submission Open

Keywords: formulation; excipients labelling; adverse effects; inactive ingredients; stability; regulation and quality; safety

(This special issue belongs to the Section Pharmaceutical Technology)

G-Protein-Coupled Receptors as Therapeutic Targets for CNS Disorders

edited by

Fabio Del Bello

and Wilma Quaglia

submission deadline 24 Jul 2026 | Viewed by 529 | Submission Open

Keywords: GPCRs; CNS disorders; biased ligands; allosteric modulators; GPCR heteromers; multitarget ligands

(This special issue belongs to the Section Pharmacology)

Emerging Therapies for Diabetes and Obesity

edited by Pedro Cisternas

submission deadline 25 Jul 2026 | 6 articles | Viewed by 14442 | Submission Open

Keywords: insulin resistance; adipose tissue dysfunction; antidiabetic agents; metabolic disease; metabolic inflammation; pharmacological interventions

(This special issue belongs to the Section Pharmacology)

Clinical Advances in the Neuropharmacological Treatment of Substance Use Disorders: 2nd Edition

edited by

Stefania Chiappini

submission deadline 25 Jul 2026 | 3 articles | Viewed by 10736 | Submission Open

Keywords: neuropharmacology; drug abuse; addiction; substance abuse

(This special issue belongs to the Section Pharmacology)

Advances in Hybrid Anticancer Drugs: Innovations and Therapeutic Potential

edited by

Dmytro Khylyuk

submission deadline 25 Jul 2026 | 6 articles | Viewed by 8195 | Submission Open

Keywords: drug design; molecular hybrids; anticancer agents; privileged scaffold; multiple mechanisms of action

(This special issue belongs to the Section Medicinal Chemistry)

Dental Medication

edited by

Michelle Franz-Montan

and

Camila Batista Da Silva

submission deadline 25 Jul 2026 | 1 articles | Viewed by 3493 | Submission Open

Keywords: dental medication; local anesthetics; controlled drug delivery; nanotechnology in dentistry; therapeutic biomaterials; smart drug delivery systems; digital health in dental pharmacology; dental materials

(This special issue belongs to the Section Pharmaceutical Technology)

Advances in Perinatal Pharmacology

edited by

Khaled Abduljalil

and

Raj Badhan

submission deadline 25 Jul 2026 | 3 articles | Viewed by 3292 | Submission Open

Keywords: maternal; perinatal; neonatal; pharmacology; placenta; pregnancy

(This special issue belongs to the Section Pharmacology)

Development of Antibacterial Drugs to Combat Drug-Resistant Bacteria: 2nd Edition

edited by

Adriána Liptáková

and Iryna Voronkina

submission deadline 25 Jul 2026 | 2 articles | Viewed by 2509 | Submission Open

Keywords: development of antibacterial drugs; drug-resistant bacteria; antimicrobial resistance; new therapeutic solutions; improvement of existing therapies; nosocomial infections

(This special issue belongs to the Section Pharmacology)

Network Pharmacology of Natural Products, 3rd Edition

edited by

Alexander George Panossian

Karl Wah-Keung Tsim

and

Thomas Efferth

submission deadline 25 Jul 2026 | 2 articles | Viewed by 2003 | Submission Open

Keywords: natural compounds; plant extracts; structure-activity relationship; network pharmacology; multitarget effects; synergy of complex preparations; pleiotropic activity

(This special issue belongs to the Section Natural Products)

Research Progress and Drug Intervention Strategies for Oral Health-Related Diseases

edited by

Claudia Florina Bogdan-Andreescu

and Mariana Pacurar

submission deadline 25 Jul 2026 | 1 articles | Viewed by 1714 | Submission Open

Keywords: oral health; dental caries; periodontal diseases; drug intervention; biomaterials; biomarkers; microbiome; pharmacogenomics; targeted therapy; oral drug delivery; oral disease prevention

(This special issue belongs to the Section Pharmacology)

Pharmacotherapy of Inflammatory Bowel Disease, 2nd Edition

edited by

Wolfgang Kruis

submission deadline 25 Jul 2026 | 1 articles | Viewed by 1254 | Submission Open

Keywords: treatment of Crohn's Disease; treatment of ulcerative colitis; mesalamine for ulcerative colitis; mesalamine for Crohn's Disease; antibody strategies in IBD; small molecules for IBD; conservative management of Crohn's fistula; therapy for extraintestinal manifestations; new endpoints for treatment

(This special issue belongs to the Section Pharmacology)

Drug Target Exploration and Drug Design & Development Based on Small Molecule: 2nd Edition

edited by

Marco Tutone

and

Giulia Culletta

submission deadline 25 Jul 2026 | 1 articles | Viewed by 1181 | Submission Open

Keywords: small molecules; drug design and development; target exploration; anticancer drugs; anti-inflammatory drugs; neuromodulation; natural compounds; nutraceuticals; virtual screenings

(This special issue belongs to the Section Pharmacology)

Design, Synthesis and Evaluation of Novel 18F Radiotracers

edited by

Junfeng Li

and John E. Shively

submission deadline 25 Jul 2026 | Viewed by 369 | Submission Open

Keywords: positron emission tomography (PET); fluorine-18 (F-18); radiotracer development; molecular imaging; non-invasive diagnostic technique; synthetic methodologies; preclinical evaluation

(This special issue belongs to the Section Radiopharmaceutical Sciences)

Therapeutic Drug Monitoring and Adverse Drug Reactions: 3rd Edition

edited by Engi Abd El Hady Algharably and

Ursula Gundert-Remy

submission deadline 25 Jul 2026 | Viewed by 293 | Submission Open

Keywords: therapeutic drug monitoring; adverse drug reactions; pharmacokinetics; personalized medicine; medication safety; pharmacogenomics; medication review; pharmacokinetic modeling

(This special issue belongs to the Section Pharmacology)

Therapeutic Strategies for Co-Occurring Psychiatric and Substance Use Disorders

edited by Clara Cavallotto and

Stefania Chiappini

submission deadline 25 Jul 2026 | Viewed by 264 | Submission Open

Keywords: dual diagnosis; substance use disorder; schizophrenia spectrum disorder; antipsychotic; pharmacological treatment

(This special issue belongs to the Section Pharmacology)

Therapeutic Potential of Cannabinoids and Their Receptors: 2nd Edition

edited by Kruk-Słomka Marta

submission deadline 25 Jul 2026 | Viewed by 221 | Submission Open

Keywords: endocannabinoid system; cannabinoid receptor ligands; medical marihuana; cannabinoid-based therapies

(This special issue belongs to the Section Pharmacology)

Development of Biomaterials for Targeted and Localized Cancer Drug Release

edited by Precious O. Etinosa and

John David Obayemi

submission deadline 25 Jul 2026 | Viewed by 214 | Submission Open

Keywords: targeted delivery; localized drug release; controlled release kinetics; cancer biomaterials; injectable hydrogels; implantable depots; nanoparticles/microparticles; tumor microenvironment

(This special issue belongs to the Section Pharmaceutical Technology)

Pharmaceutical Applications of Metal Nanoparticles

edited by Andrew Knight

submission deadline 25 Jul 2026 | Viewed by 195 | Submission Open

Keywords: metal nanoparticles; nanomedicine; target drug delivery; theranostics; biocompatability and toxicity

(This special issue belongs to the Section Pharmaceutical Technology)

Novel Drug Targets and Drug Candidates for Neglected Tropical Diseases

edited by Juliana Mesquita and

Juliana Quero Reimão

submission deadline 27 Jul 2026 | 5 articles | Viewed by 6592 | Submission Open

Keywords: neglected tropical diseases; leishmaniasis; chagas disease

(This special issue belongs to the Section Medicinal Chemistry)

Advances in Drug Analysis and Drug Development, 2nd Edition

edited by

Daniela Amidžić Klarić

and Ana Mornar

submission deadline 27 Jul 2026 | 5 articles | Viewed by 6583 | Submission Open

Keywords: analytical methodology; chromatographic techniques; spectrometric techniques; thermal analysis techniques; sample preparation; drug stability; compatibility study; bioavailability studies; therapeutic drug monitoring; quality by design in pharmaceutical analysis

(This special issue belongs to the Section Pharmaceutical Technology)

Displaying special issue 51-100 on page 2 of 8.

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