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Pharmaceuticals publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Multitargeted Compounds: A Promising Approach in Medicinal Chemistry—2nd Edition

edited by Abdallah Hamze

submission deadline 28 Aug 2026 | Viewed by 297 | Submission Open

Keywords: multitargeted compounds; medicinal chemistry; rational design; drug discovery; synergistic effects; emerging technologies; therapeutic applications; dual compounds

(This special issue belongs to the Section Medicinal Chemistry)

Natural Compounds and Extracts Loaded into Advanced Delivery Platforms

edited by Judyta Cielecka-Piontek,

Anna Stasiłowicz-Krzemień

and

Nunzio Denora

submission deadline 30 Aug 2026 | Viewed by 299 | Submission Open

Keywords: bioavailability enhancement; biopolymer-based carriers; controlled delivery; nanoencapsulation; nanocarriers; natural bioactive compounds; phytochemical delivery systems; plant extract formulations; sustainable delivery systems; targeted delivery

(This special issue belongs to the Section Natural Products)

Plant-Based Extracts and the Therapeutic Potential of Bioactive Compounds, 2nd Edition

edited by

Grażyna Zgórka

submission deadline 31 Aug 2026 | 8 articles | Viewed by 17612 | Submission Open

Keywords: plant extracts; herbal medicinal products; standardization; phytochemical profiling; bioactive plant compounds; therapeutic effects

(This special issue belongs to the Section Natural Products)

Bioactive Compounds from Plants and Foods: From Traditional Medicine to Modern Applications in Nutrition and Health

edited by

Sendar Nery-Flores

Filiberto Gutierrez-Gutierrez

, Walter Trujillo-Rangel and

Raúl Rodríguez-Herrera

submission deadline 31 Aug 2026 | 5 articles | Viewed by 5630 | Submission Open

Keywords: herbal extracts; natural compounds; nutraceuticals; bioactive compounds; in vitro and in vivo studies; biological activities; phytochemistry; natural product drug discovery; computational screening of natural products; nanomaterials for natural product extraction

(This special issue belongs to the Section Natural Products)

Metabolism, Inflammation and Neurodegeneration: Natural Compounds as Therapeutic Agents

edited by Pedro Cisternas

submission deadline 31 Aug 2026 | 3 articles | Viewed by 3632 | Submission Open

Keywords: neurodegenerative diseases; natural compounds; metabolic dysfunction; neuroinflammation; therapeutic strategies

(This special issue belongs to the Section Natural Products)

Applications of Pharmacogenomics in Precision Medicine

edited by

Kariofyllis Karamperis

, Branka Zukic and

Fernanda Rodrigues-Soares

submission deadline 31 Aug 2026 | 2 articles | Viewed by 3266 | Submission Open

Keywords: personalized medicine; pharmacogenomics; drug– gene interactions; adverse drug reactions; pharmacogenomic biomarkers; multi-omics; population pharmacogenomics; precision therapeutics

(This special issue belongs to the Section Pharmacology)

Novel Vasoactive and Anti-Inflammatory Agents: From Mechanisms to Therapeutic Applications

edited by

Thyago Moreira De Queiroz

and Alice Valença Araújo

submission deadline 31 Aug 2026 | 3 articles | Viewed by 2281 | Submission Open

Keywords: vasorelaxation; inflammation; oxidative stress; nitric oxide; natural and synthetic products; blood pressure

(This special issue belongs to the Section Pharmacology)

Pyrazole and Its Derivatives: Drug Design, Synthesis, and Biological Evaluation

edited by

Matteo Lusardi

and

Marco Ponassi

submission deadline 31 Aug 2026 | 1 articles | Viewed by 2154 | Submission Open

Keywords: medicinal chemistry; drug design; drug discovery; pyrazole-based compounds; innovative synthesis; structure– activity relationships; biological activities; drug-like properties

(This special issue belongs to the Section Medicinal Chemistry)

Research on Guanidine-Based Drugs: Synthesis, Antiparasitic, Antifungal, Antiviral, and Anticancer Activities

edited by

Eduardo René Pérez González

Eduardo Henrique Zampieri

, Francisco Jaime Bezerra Mendonça-Junior,

Eduardo Maffud Cilli

and

Ana Marisa Fusco Almeida

submission deadline 31 Aug 2026 | 2 articles | Viewed by 2077 | Submission Open

Keywords: guanidine derivatives; medicinal chemistry; SAR analysis; neglected diseases; antiparasitic; antifungal; antiviral; anticancer; drug development

(This special issue belongs to the Section Medicinal Chemistry)

New Perspective of Antiviral Drugs

edited by

Grigoris Zoidis

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1808 | Submission Open

Keywords: antiviral drugs; antiviral agents; small organic molecules; metal complexes; natural products

(This special issue belongs to the Section Medicinal Chemistry)

Current Advances, Applications and Future Development of Transition Metal Complexes, 2nd Edition

edited by

Domenico Iacopetta

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1568 | Submission Open

Keywords: transition metal complexes; synthesis; catalysis; ligands; biological activity; applications; enzyme inhibition

(This special issue belongs to the Section Medicinal Chemistry)

Molecular Systems for the Delivery of Drugs and Contrast Agents, 2nd Edition

edited by

Angelo Maspero

Luca Nardo

and

Marco Lamperti

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1380 | Submission Open

Keywords: biomarker-targeted drugs; contrast media for diagnostic imaging; drug delivery systems; photoactivated drugs and photoswitches; theranostics; liposomes; biomaterials-based drugs and drug shuttles (e.g.; DNA origami); biomimetic materials; nanoparticle applications to diagnostics and therapy; in silico drug design

(This special issue belongs to the Section Medicinal Chemistry)

Application of Natural Products in Retinal Disorders Therapy

edited by

Francesca Corsi

and

Maria Claudia Gargini

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1086 | Submission Open

Keywords: natural products; retinal disorders; neuroprotection; oxidative stress; retinal inflammation; retinal neurodegeneration; nutraceuticals; in vitro and in vivo retinal models

(This special issue belongs to the Section Natural Products)

Natural Products Drug Discovery and Their Pharmacological Applications

edited by Rosana Crespo

submission deadline 31 Aug 2026 | 1 articles | Viewed by 947 | Submission Open

Keywords: natural product; pharmaceutical applications; neurodegenerative disorders

(This special issue belongs to the Section Natural Products)

Cancer Therapeutics: Drug Repurposing and Computational Strategies

edited by

Minh Tuan Nguyen

submission deadline 31 Aug 2026 | 1 articles | Viewed by 890 | Submission Open

Keywords: cancer therapeutics; drug repurposing; computer-aided drug design (CADD); molecular dynamics simulation; virtual screening; targeted therapy; structure-based drug design; molecular docking; pharmacophore modeling

(This special issue belongs to the Section AI in Drug Development)

Discovery of Natural Products to Promote the Wound Healing

edited by

Ying Li

submission deadline 31 Aug 2026 | Viewed by 603 | Submission Open

Keywords: natural ingredients; natural biomedical polymers; drug delivery; nanomedicine; hydrogels; wound healing

Advances in Neuropharmacology and Brain Injury Therapeutics

edited by

Bruce X.W. Wong

and

Kaelyn Tan

submission deadline 31 Aug 2026 | Viewed by 457 | Submission Open

Keywords: neurodegenerative diseases; brain injuries; nanomedicine and targeted delivery; stem cell and regenerative therapies; precision medicine and diagnostic biomarkers

(This special issue belongs to the Section Pharmacology)

Contemporary Challenges and Solutions in Antimicrobial Use

edited by

Anca-Maria Arseniu

Alina Bereanu

and

Bogdan Vintila

submission deadline 31 Aug 2026 | Viewed by 437 | Submission Open

Keywords: antimicrobial use; novel drug delivery systems; biological barriers

(This special issue belongs to the Section Pharmacology)

From Prion Molecular Mechanisms to Targeted Therapeutics: Informing the Broader Proteinopathy Paradigm

edited by Patricia Aguilar-Calvo

submission deadline 31 Aug 2026 | Viewed by 353 | Submission Open

Keywords: prion diseases; prion-like; protein aggregation; proteinopathies; neurodegeneration; neurotoxicity; diagnostics; therapeutic strategies

(This special issue belongs to the Section Pharmacology)

Hybrid Molecules in Medicinal Chemistry: Design, Synthesis and Biological Evaluation

edited by

Tao Zhang

and John J. Walsh

submission deadline 31 Aug 2026 | Viewed by 288 | Submission Open

Keywords: hybrid molecules; medicinal chemistry; drug discovery; drug development; structure– activity relationships (SAR); multitarget-directed ligands; natural products; synthetic chemistry; biological evaluation; therapeutic innovation

(This special issue belongs to the Section Medicinal Chemistry)

Innovations in Integrin-Targeted Drug Delivery: From Peptide Conjugates to Dual-Action Therapeutics

edited by

Kelly Bugatti

Lucia Battistini

and

Andrea Sartori

submission deadline 31 Aug 2026 | Viewed by 260 | Submission Open

Keywords: integrins; peptide-drug conjugates (PDCs); drug delivery; peptide synthesis; dual conjugates

(This special issue belongs to the Section Biopharmaceuticals)

Protein Silencing in Pharmaceutical Applications

edited by

Hamidreza Montazeri Aliabadi

submission deadline 31 Aug 2026 | Viewed by 252 | Submission Open

Keywords: siRNA; CRISPR/Cas9; protein silencing; cancer; in vivo; clinical applications

(This special issue belongs to the Section Biopharmaceuticals)

Active Molecule Design Based on Conformational Pharmacology: Synthesis, NMR Spectroscopy, and Computational Modeling

edited by

Nikitas Georgiou

and

Demeter Tzeli

submission deadline 31 Aug 2026 | Viewed by 249 | Submission Open

Keywords: DFT; molecular docking; NMR; molecular dynamics

(This special issue belongs to the Section Pharmacology)

Bio-Based Materials from Food Sources: Advanced Platforms for Drug Delivery and Regenerative Therapeutics

edited by

Chengliang Li

, Min Wu and

Ruoyang Zhao

submission deadline 31 Aug 2026 | Viewed by 248 | Submission Open

Keywords: food biomacromolecules; natural proteins and peptides; formulation science; controlled release; targeted delivery; bone regeneration; wound healing; drug delivery

(This special issue belongs to the Section Pharmaceutical Technology)

Antioxidant Therapeutics: From Discovery to Clinical Practice

edited by

Alain R. Rodríguez-Orozco

and

Christian Cortés-Rojo

submission deadline 31 Aug 2026 | Viewed by 229 | Submission Open

Keywords: antioxidants; ethnobotany; natural products; biopharmaceuticals; bioactive antioxidants

(This special issue belongs to the Section Natural Products)

Endocannabinoid-Like Mediators and Their Derivatives

edited by Irene Palenca and

Martina Vincenzi

submission deadline 31 Aug 2026 | Viewed by 203 | Submission Open

Keywords: bioactive lipids; lipid mediators; cell signaling; inflammation; neuroimmune interaction; molecular pharmacology; therapeutic targets; translational research; metabolic disorders; precision medicine

(This special issue belongs to the Section Medicinal Chemistry)

Pharmacological Innovations for Healthy Ageing Throughout Life

edited by

Luca Soraci

submission deadline 31 Aug 2026 | Viewed by 192 | Submission Open

Keywords: age-related diseases; pharmacological innovations; adverse drug events

(This special issue belongs to the Section Medicinal Chemistry)

Advances in Drug Treatment of Systemic Amyloidosis

edited by Juan González-Moreno

submission deadline 31 Aug 2026 | Viewed by 173 | Submission Open

Keywords: amyloid protein misfolding; disease-modifying therapies; gene-silencing strategies; protein stabilizers; translational pharmacology

(This special issue belongs to the Section Pharmacology)

Medicinal Chemistry of Thiazine and Oxazine Derivatives: Trends and Future Directions as Therapeutic Drugs

edited by

Berenika M. Szczȩśniak-Siȩga

and

Żaneta Czyżnikowska

submission deadline 10 Sep 2026 | 1 articles | Viewed by 2487 | Submission Open

Keywords: thiazine; oxazine; morpholine; thiomorpholine; benzothiazine; phenothiazine; synthesis; drug; anti-inflammatory; anticancer

(This special issue belongs to the Section Medicinal Chemistry)

Pharmacogenomics and Pediatric Pharmacotherapy

edited by

Chakradhara Rao Satyanarayana Uppugunduri

submission deadline 10 Sep 2026 | Viewed by 432 | Submission Open

Keywords: pharmacokinetics; pediatric formulations; pharmacodynamics; drug metabolism; pharmacogenetics; drug transport; ontogeny developmental pattern; modeling; drug safety; simulation; off-label drug use

(This special issue belongs to the Section Pharmacology)

Biomarkers in the Treatment of Cardiovascular Diseases

edited by

Luca Marino

submission deadline 10 Sep 2026 | Viewed by 245 | Submission Open

Keywords: biomarkers; precision medicine; pharmacogenomics; heart failure phenotyping; molecular cardiology

(This special issue belongs to the Section Medicinal Chemistry)

Pharmaceutical Formulation Characterization Design, 2nd Edition

edited by

Katalin Kristó

and

Tamás Sovány

submission deadline 15 Sep 2026 | 2 articles | Viewed by 1546 | Submission Open

Keywords: Quality by Design; factorial design; design space; solid dosage forms; risk assessment; critical process parameters; quality target product profile

(This special issue belongs to the Section Pharmaceutical Technology)

Structural Insights into Protein Kinases-Targeted Therapies: Overcoming Resistance and Advancing Precision Oncology

edited by David Hecht

submission deadline 20 Sep 2026 | 4 articles | Viewed by 5044 | Submission Open

Keywords: protein kinases inhibitor resistance; structural biology of of protein kinases; computational modeling; drug design; preclinical and clinical studies; precision oncology; ALK resistance for personalized medicine

(This special issue belongs to the Section Medicinal Chemistry)

Natural Antioxidants from Medicinal Plants: Extraction and Bioactivity

edited by

Julio Escalona-Arranz

and

Jesús García-Díaz

submission deadline 20 Sep 2026 | Viewed by 516 | Submission Open

Keywords: natural antioxidants; medicinal plants; extraction methods; bioactivity; phenolic compounds; free radical scavenging; pharmacological potential; in silico and in vitro correlation; molecular modeling

(This special issue belongs to the Section Natural Products)

Computation-Driven Discovery of Modern Small-Molecule Therapeutics: From Enzyme Inhibition to Targeted Protein Degradation

edited by

Yudibeth Sixto-López

submission deadline 20 Sep 2026 | Viewed by 308 | Submission Open

Keywords: computer-aided drug design; small-molecule drugs; enzyme inhibition; PROTACs; molecular docking; molecular dynamics simulation; artificial intelligence in drug design; virtual screening

(This special issue belongs to the Section AI in Drug Development)

Multiomics Perspective in Pharmacogenomics

edited by

Alireza Tafazoli

submission deadline 20 Sep 2026 | Viewed by 193 | Submission Open

Keywords: clinical pharmacogenomics; epigenomics in pharmacogenomics; transcriptomics in pharmacogenomics; proteomics and metabolomics in pharmacogenomics; microbiome in pharmacogenomics; multiomics in pharmacogenomics; AI and computational tools in pharmacogenomics; genome profiling in pharmacogenomics; metadata in pharmacogenomics

(This special issue belongs to the Section Pharmacology)

Medicinal Plants: Exploring Plant-Based Bioactive Compounds for Cancer and Metabolic Diseases Prevention and Intervention

edited by

Lucas Fornari Laurindo

and

Sandra Barbalho

submission deadline 25 Sep 2026 | 9 articles | Viewed by 23191 | Submission Open

Keywords: cancer; metastasis; tumor growth; tumor spread; bioactive compounds; phytochemicals; medicinal plants; phytochemistry; cancer prevention; cancer intervention; metabolic diseases; metabolism; diabetes; MAFLD; dyslipidemia

(This special issue belongs to the Section Natural Products)

Advances in Prostate Cancer Therapeutics

edited by

David Danielpour

submission deadline 25 Sep 2026 | 5 articles | Viewed by 13808 | Submission Open

Keywords: prostate cancer; androgen deprivation therapy (ADT); castration-resistant prostate cancer (CRPC); androgen receptor signaling inhibitors; PARP inhibitors; ionizing radiation therapy; radiopharmaceuticals; immunotherapy; biomarkers; personalized medicine; therapeutic resistance; targeted therapy; combination therapy; hormone-sensitive prostate cancer (HSPC); next-generation therapeutics; translational oncology

(This special issue belongs to the Section Pharmacology)

Heterocyclic Compounds in Medicinal Chemistry, 2nd Edition

edited by

Valentina Noemi Madia

and

Davide Ialongo

submission deadline 25 Sep 2026 | 5 articles | Viewed by 12783 | Submission Open

Keywords: heterocycles; drug design; drug discovery; bioactive compounds; structure-based drug design; structure– activity relationship; in silico studies; ADMET properties; multicomponent reactions; phytochemicals

(This special issue belongs to the Section Medicinal Chemistry)

Advances in Topical and Mucosal Drug Delivery Systems

edited by

Michelle Franz-Montan

submission deadline 25 Sep 2026 | 5 articles | Viewed by 9851 | Submission Open

Keywords: topical drug delivery; mucosal drug delivery; transdermal drug delivery; controlled release; bioavailability enhancement; formulation development

(This special issue belongs to the Section Pharmaceutical Technology)

Cutting-Edge Biotechnologies and Applications of Natural Products in Drug R&D and Disease Treatment

edited by

Sujay Paul

submission deadline 25 Sep 2026 | 4 articles | Viewed by 9143 | Submission Open

Keywords: natural products; bioactive compounds; natural product drug discovery and drug design; natural drug formulation; metabolic engineering for bioactive compounds; natural therapeutic agents; nanoformulations of natural compounds; synthetic biology for natural product biosynthesis; genome editing and creation of novel bioactive compounds

(This special issue belongs to the Section Natural Products)

Natural Products with Anticancer Activity

edited by

Epole Ntungwe

submission deadline 25 Sep 2026 | 3 articles | Viewed by 4789 | Submission Open

Keywords: natural products; extracts; anticancer activities; phytochemicals; molecular mechanisms

(This special issue belongs to the Section Medicinal Chemistry)

Natural Products and Bioactive Compounds for the Prevention and Treatment of Non-Communicable Chronic Diseases

edited by

Priscila de Souza

submission deadline 25 Sep 2026 | 3 articles | Viewed by 3638 | Submission Open

Keywords: natural products; phytochemicals; chronic diseases; functional foods; herbal medicine; non-communicable diseases; ethnopharmacology; bioactivity

(This special issue belongs to the Section Natural Products)

Targeting Enzymes in Drug Design and Discovery

edited by

Mariyana Atanasova

submission deadline 25 Sep 2026 | 2 articles | Viewed by 2371 | Submission Open

Keywords: drug design; computer-aided drug design (CADD); molecular docking; molecular dynamics; QSAR; druggable proteins; synthesis; in vitro and in vivo activity evaluations; ADMET predictions and evaluations

(This special issue belongs to the Section Biopharmaceuticals)

Advances in the Medicinal Synthesis of Bioactive Compounds

edited by

Iliyan Ivanov

and

Stanimir Manolov

submission deadline 25 Sep 2026 | 1 articles | Viewed by 2344 | Submission Open

Keywords: medicinal chemistry; bioactive compounds; synthetic methodologies; structure– activity relationship (SAR); drug discovery; pharmacokinetics; therapeutic agents; green chemistry; computational modeling; interdisciplinary research

(This special issue belongs to the Section Medicinal Chemistry)

Therapies for Autoimmune Diseases

edited by

Athanasios Sachinidis

and

Carlo Perricone

submission deadline 25 Sep 2026 | Viewed by 2282 | Submission Open

Keywords: autoimmune diseases; immunotherapy; immunomodulation; biologic therapies; small molecule drugs; therapeutic vaccines; tolerogenic strategies; monoclonal antibodies; personalized medicine; targeted drug delivery

(This special issue belongs to the Section Medicinal Chemistry)

Biological Properties of Nanostructures Incorporated in Polymeric Matrices

edited by

Isabella Macário Ferro Cavalcanti

submission deadline 25 Sep 2026 | 1 articles | Viewed by 1269 | Submission Open

Keywords: antimicrobial resistance; cancer; diseases; nanotechnology; polimer

(This special issue belongs to the Section Pharmaceutical Technology)

Drug Delivery Strategies for Brain Targeting and Drug Repurposing: Exploring Alternative Routes and Novel Pharmacological Targets

edited by Paraskevi Papakyriakopoulou and

Kumlesh Kumar Dev

submission deadline 25 Sep 2026 | 1 articles | Viewed by 1213 | Submission Open

Keywords: drug repurposing; brain drug delivery; delivery-driven repurposing; brain pharmacokinetics; brain pharmacodynamics; CNS-targeted drug delivery

(This special issue belongs to the Section Pharmaceutical Technology)

Nanocarriers in Cancer Therapy: From Drug Delivery to Radiotherapy

edited by

Abdulaziz Alhussan

and

Dimitris Tsiourvas

submission deadline 25 Sep 2026 | 1 articles | Viewed by 1025 | Submission Open

Keywords: cancer nanomedicine; lipid nanoparticles; drug delivery; radiotherapy enhancement; nanocarriers; tumor microenvironment; nano-immunotherapy; cancer vaccines; stimuli-responsive systems

(This special issue belongs to the Section Pharmaceutical Technology)

Recent Advancements in the Development of Antiprotozoal Agents: 2nd Edition

edited by Francesco Saccoliti and Alessandro Giraudo

submission deadline 25 Sep 2026 | 1 articles | Viewed by 959 | Submission Open

Keywords: antiprotozoal; drug discovery; chemotherapy; parasite; protozoa; mechanism of antiprotozoal agents

(This special issue belongs to the Section Medicinal Chemistry)

Displaying special issue 151-200 on page 4 of 8.

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