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Pharmaceuticals publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Radionuclide Production and Their Applications in Therapeutic Radiopharmaceuticals

edited by Svetlana Selivanova

submission deadline 31 Aug 2025 | Viewed by 110 | Submission Open

Keywords: radiopharmaceutical sciences; radiochemistry; radiopharmacology; radionuclide production; molecular imaging

(This special issue belongs to the Section Radiopharmaceutical Sciences)

Stem Cells in Oncology: Emerging Targets for Therapy

edited by

Ling Li

and

Umesh P Yadav

submission deadline 31 Aug 2025 | Viewed by 78 | Submission Open

Keywords: cancer stem cells (CSCs); tumor microenvironment (TME); targeted therapy; treatment resistance; biomarkers

(This special issue belongs to the Section Biopharmaceuticals)

Design, Synthesis and Biological Assessment of Amphiphiles

edited by

Renata Odžak

and

Matilda Šprung

submission deadline 1 Sep 2025 | Viewed by 276 | Submission Open

Keywords: amphiphilic compounds; structure– activity relationship; biological potential

(This special issue belongs to the Section Medicinal Chemistry)

Bioactive Compounds Derived from Plants and Their Medicinal Potential, 2nd Edition

edited by

Maria de Lourdes Pereira

Veeranoot Nissapatorn

, Ana Paula Girol and

Sónia M. R. Oliveira

submission deadline 5 Sep 2025 | 2 articles | Viewed by 1362 | Submission Open

Keywords: phytopharmaceutical drugs; activity screening (antimicrobial; antioxidant; anticancer; and immunomodulatory activity); experimental models (in vitro; ex vivo; in vivo; etc.); microfluidic systems

(This special issue belongs to the Section Natural Products)

Emerging Freeze Drying and Spray Drying Techniques

edited by

Lauryna Pudžiuvelytė

and

Jurga Bernatoniene

submission deadline 10 Sep 2025 | 1 articles | Viewed by 4429 | Submission Open

Keywords: freeze drying; spray drying; microencapsulation; emulsions; herbal extracts; essential oil; natural ingredients; active ingredients; wall materials; polysaccharides; powders; physicochemical characteristics; microparticles; encapsulation efficiency; biological activity; pharmaceutical forms (tablets; capsules; solutions; gels; etc.); study of stability; study of release in vitro; active compound(s) and wall material interaction; morphology of microparticles

(This special issue belongs to the Section Pharmaceutical Technology)

New Targets and Experimental Therapeutic Approaches for Cancers

edited by

Saurabh Agarwal

and Rohit K. Srivastava

submission deadline 10 Sep 2025 | 2 articles | Viewed by 2897 | Submission Open

Keywords: cancer; pharmaceutical therapy; therapeutic targets; drug delivery; immunotherapy; precision medicine; emerging pharmaceutical technologies; combination therapy

(This special issue belongs to the Section Pharmacology)

Recent Advances in Nanocarriers for Drug Delivery

edited by

Liliana Mititelu-Tartau

submission deadline 15 Sep 2025 | 2 articles | Viewed by 1883 | Submission Open

Keywords: nanocarriers; drug delivery; targeted therapy; controlled release; biocompatibility; liposomal delivery; polymeric nanoparticles; gene therapy; smart drug systems; biomedical applications

(This special issue belongs to the Section Pharmaceutical Technology)

Novel Antimicrobials and the Antimicrobial Activity: New Advances

edited by

Davide Carcione

Luigi Principe

and

Cattaneo Dario

submission deadline 15 Sep 2025 | Viewed by 472 | Submission Open

Keywords: multi-drug resistance; infection; mechanism of action; resistance mechanisms; therapeutic medicine; diagnostic tools; antimicrobial stewardship; pharmacokinetics/pharmacodynamics

(This special issue belongs to the Section Pharmacology)

Triazole and Derivatives in Medicinal Chemistry, 2nd Edition

edited by Saeed Bahadorikhalili

submission deadline 15 Sep 2025 | Viewed by 250 | Submission Open

Keywords: triazole; heterocycles; medicinal chemistry; pharmaceutical chemistry; organic synthesis; catalytic organic synthesis; bioactivity; organocatalysis

(This special issue belongs to the Section Medicinal Chemistry)

Peptide Drug Conjugates and Their Applications

edited by

Stela Georgieva

and

Petar Todorov

submission deadline 20 Sep 2025 | 1 articles | Viewed by 2390 | Submission Open

Keywords: peptides; endogenous opioid peptides; peptidomimetics; neuropeptides; peptide– metal complexes; opioid receptors; chemical biology of peptides

(This special issue belongs to the Section Biopharmaceuticals)

Pharmaceutical Strategy for Mood Disorders

edited by Delfina Janiri and Alexia Koukopoulos

submission deadline 22 Sep 2025 | 1 articles | Viewed by 98 | Submission Open

Keywords: mood disorders; pharmacotherapy; pharmacological targets; gut– brain axis; microbiome-based interventions; biomarker-driven treatment optimize treatment response

(This special issue belongs to the Section Pharmacology)

Pharmacokinetic Modeling and Simulation in the Design of Long-Acting Drug Delivery Systems

edited by Mackenzie Cottrell and

Leah M. Johnson

submission deadline 22 Sep 2025 | Viewed by 95 | Submission Open

Keywords: long-acting drug delivery systems (LADDSs); pharmacokinetic modeling; pharmacokinetic simulation; physiologically based pharmacokinetic (PBPK) modeling; quantitative systems pharmacology (QSP); absorption; in vitro– in vivo correlation (IVIVC); model-informed drug development (MIDD); artificial intelligence (AI); machine learning (ML); drug disposition; controlled release

(This special issue belongs to the Section Pharmaceutical Technology)

Fighting Tropical Neglected Diseases with Natural Products: New Approaches Against Ancient Diseases

edited by

Igor Rodrigues

André Luis Souza dos Santos

, Dirlei Nico and Ana Claudia Fernandes Amaral

submission deadline 23 Sep 2025 | 2 articles | Viewed by 1766 | Submission Open

Keywords: plant extracts; natural compounds; neglected diseases; drug resistance; natural product-based formulations; antiparasitic drugs; enzyme inhibition

Recent Advances in Inhalation Therapy

edited by

Luca Casula

and

Francesco Lai

submission deadline 25 Sep 2025 | 5 articles | Viewed by 14667 | Submission Open

Keywords: inhalation therapy; pulmonary delivery; aerosols; dry powder inhalation; inhalable micro and nanoparticles; pulmonary deposition

(This special issue belongs to the Section Pharmaceutical Technology)

Pharmacotherapy of Liver Fibrosis and Hepatitis: Recent Advances

edited by

Ching-Lung Lai

submission deadline 25 Sep 2025 | 8 articles | Viewed by 11530 | Submission Open

Keywords: treatment of HBV; HCV; SLD; detection and prevention of liver fibrosis and HCC

(This special issue belongs to the Section Pharmacology)

Pharmacogenomics for Precision Medicine

edited by

Vacis Tatarūnas

submission deadline 25 Sep 2025 | 6 articles | Viewed by 8651 | Submission Open

Keywords: pharmacogenomics in precise therapy; tailored medicine; pharmacoeconomics; personalized medicine; education in pharmacogenomics and precise medicine; future directions in pharmacogenomics; pharmacogenomics and phenotype; genotype; epigenetic variation; and gene expression axis in pharmacogenomics

(This special issue belongs to the Section Pharmacology)

Recent Advancements in the Development of Antiprotozoal Agents

edited by Francesco Saccoliti and Alessandro Giraudo

submission deadline 25 Sep 2025 | 4 articles | Viewed by 8184 | Submission Open

Keywords: antiprotozoal; drug discovery; chemotherapy; parasite; protozoa; mechanism of action of antiprotozoal agents

(This special issue belongs to the Section Medicinal Chemistry)

Antiviral Agents, 2024

edited by

Luis Octavio Regasini

submission deadline 25 Sep 2025 | 4 articles | Viewed by 7772 | Submission Open

Keywords: antiviral; virus; arbovirus; drugs; protease; helicase; polymerase; reverse transcriptase

(This special issue belongs to the Section Medicinal Chemistry)

Advances in Pediatric Drug Formulations

edited by

Sonia M. Iurian

Ioan Tomuta

and

Catalina Bogdan

submission deadline 25 Sep 2025 | 3 articles | Viewed by 5325 | Submission Open

Keywords: pediatric dosage forms; child-friendly dosage forms; age-appropriate dosage forms; acceptability; administration devices; taste-masking; compounded pediatric formulations

(This special issue belongs to the Section Pharmaceutical Technology)

Drug Safety and Risk Management in Clinical Practice

edited by Andreea Maria Farcas

submission deadline 25 Sep 2025 | 3 articles | Viewed by 3826 | Submission Open

Keywords: drug safety; adverse drug reactions; risk minimization measures; effectiveness of risk minimization measures; drug utilization studies

(This special issue belongs to the Section Pharmacology)

Drug Treatment of Cholangiocarcinoma

edited by

Abdullah Esmail

submission deadline 25 Sep 2025 | 1 articles | Viewed by 3339 | Submission Open

Keywords: cholangiocarcinoma; hepatic malignancy; intrahepatic (iCCA); perihilar (pCCA); gemcitabine; cisplatin; immunotherapy; durvalumab and distal (dCCA)

(This special issue belongs to the Section Pharmacology)

Current Advances in Therapeutic Potential of Sigma Receptor Ligands

edited by Maria Dichiara and

Emanuele Amata

submission deadline 25 Sep 2025 | 3 articles | Viewed by 3179 | Submission Open

Keywords: sigma-1 receptor; sigma-2 receptor; TMEM97; cancer; neurodegeneration; neuroprotection; pain; CNS disorders; SAR

(This special issue belongs to the Section Medicinal Chemistry)

Heterocyclic Compounds in Medicinal Chemistry, 2nd Edition

edited by

Valentina Noemi Madia

and

Davide Ialongo

submission deadline 25 Sep 2025 | 2 articles | Viewed by 2065 | Submission Open

Keywords: heterocycles; drug design; drug discovery; bioactive compounds; structure-based drug design; structure– activity relationship; in silico studies; ADMET properties; multicomponent reactions; phytochemicals

(This special issue belongs to the Section Medicinal Chemistry)

Pharmacotherapy of Dyslipidemias, 2nd Edition

edited by

Daniel Dias Rufino Arcanjo

and

Maria do Carmo de Carvalho e Martins

submission deadline 25 Sep 2025 | 1 articles | Viewed by 1986 | Submission Open

Keywords: atherosclerosis; dyslipidemia; endothelial dysfunction; fatty acids; high-fat diet; hyperlipidemia; hypertriglyceridemia; polyunsaturated fatty acids; PUFA; statins

(This special issue belongs to the Section Medicinal Chemistry)

Immunogenomics for Drug Discovery in Leukemia

edited by

Silvia Jiménez-Morales

and Adolfo Martínez-Tovar

submission deadline 25 Sep 2025 | Viewed by 1524 | Submission Open

Keywords: leukemia; hematological diseases; immunogenomics; omics studies; experimental models; therapeutic approaches

(This special issue belongs to the Section Medicinal Chemistry)

Peptide Biomaterials for Pharmaceutical Applications

edited by

Miguel Mendez-Rojas

, Sergio Alberto Bernal Chavez and

Sergio Alcalá Alcalá

submission deadline 25 Sep 2025 | 1 articles | Viewed by 1480 | Submission Open

Keywords: peptides; pharmaceutical applications; nanomedicine; peptide materials; peptide conjugates; drug delivery systems; nanocarriers; biologics

(This special issue belongs to the Section Pharmaceutical Technology)

Challenges in the Development of PET and SPECT Radiotracers: Innovative Ideas with Negative Outcomes

edited by Magali Toussaint and Barbara Wenzel

submission deadline 25 Sep 2025 | 2 articles | Viewed by 1144 | Submission Open

Keywords: radiotracer development; positron emission tomography (PET); single-photon emission computed tomography (SPECT); negative results; diagnostic radiotracers; therapeutic radiopharmaceuticals; radiolabeling; automated synthesis and GMP; pre-clinical studies; medicinal chemistry

(This special issue belongs to the Section Radiopharmaceutical Sciences)

Therapeutic Applications of Micro-RNA in Cancer Management

edited by

Alma D. Campos-Parra

submission deadline 25 Sep 2025 | 1 articles | Viewed by 1070 | Submission Open

Keywords: cancer; miRNAs; therapeutic applications; miRNA treatments

(This special issue belongs to the Section Biopharmaceuticals)

Medicinal Potential of Cannabidiol and New Structural Analogs

edited by

Patricia Fernandes

submission deadline 25 Sep 2025 | 1 articles | Viewed by 1061 | Submission Open

Keywords: cancer; inflammation; pain; analgesia; cannabidiol; parkinson disease; huntington disease; alzheimer disease

(This special issue belongs to the Section Medicinal Chemistry)

Advances in Hybrid Anticancer Drugs: Innovations and Therapeutic Potential

edited by

Dmytro Khylyuk

submission deadline 25 Sep 2025 | 1 articles | Viewed by 750 | Submission Open

Keywords: drug design; molecular hybrids; anticancer agents; privileged scaffold; multiple mechanisms of action

(This special issue belongs to the Section Medicinal Chemistry)

Novel Drug Compositions for Ischemic Stroke: Mechanisms and Clinical Applications

edited by

Jasenka Mrsic-Pelcic

and

Anja Harej Hrkać

submission deadline 25 Sep 2025 | 1 articles | Viewed by 707 | Submission Open

Keywords: ischemic stroke; novel delivery systems; nanomedicine; nanotechnology; neuroregenerative therapy; neurorepair; new and emerging treatments; pharmacotherapy; tissue engineering

(This special issue belongs to the Section Pharmacology)

Next-Generation Antibiotic Strategies Against Drug-Resistant Bacteria

edited by

Jan Naseer Kaur

, Nicholas Smith and Parikshit Padhi

submission deadline 25 Sep 2025 | 1 articles | Viewed by 562 | Submission Open

Keywords: persisters and AMR; combination pharmacotherapy; drug repurposing; antibiotic adjuvants; next-generation beta lactamase inhibitors; small molecule inhibitors; bacteriophage therapy; peptides and CRISPR-based antimicrobials; novel therapeutics; heteroresistance

(This special issue belongs to the Section Pharmacology)

Advances in the Treatment of Leukemia and Lymphomas

edited by

Adriano de Paula Sabino

, Karina Braga Gomes and Maria Das Graças Carvalho

submission deadline 25 Sep 2025 | 1 articles | Viewed by 485 | Submission Open

Keywords: leukemias; lymphomas; chemotherapy; target therapy; immunotherapy; kinase inhibitors; hematologic oncology; therapy; treatment

(This special issue belongs to the Section Medicinal Chemistry)

Psychedelics: A New Drug Candidate for Treating Mental Illness

edited by

Raphaël Serreau

and

Sabine Berteina-Raboin

submission deadline 25 Sep 2025 | 2 articles | Viewed by 472 | Submission Open

Keywords: psychedelics drugs; psilocybin; psilocin; pharmacokinetic; pharmacodynamic; new drug candidate; mental diseases

(This special issue belongs to the Section Pharmacology)

Expanding the Cancer Drug Discovery Toolbox: A Focus on Protein Degradation, Allosteric Modulation, and Covalent Inhibition

edited by Rita Maria Concetta Di Martino and

Antonella Messore

submission deadline 25 Sep 2025 | 1 articles | Viewed by 450 | Submission Open

Keywords: protein degradation; proteolysis targeting chimeras; hydrophobic tags; molecular glues; allosteric modulators; covalent inhibitors

(This special issue belongs to the Section Medicinal Chemistry)

Application of Supercritical Fluids in Pharmaceutical Science

edited by

Cecília I. A. V. Santos

submission deadline 25 Sep 2025 | Viewed by 216 | Submission Open

Keywords: supercritical fluids; scCO2; drug formulation; bioavailability; green chemistry; drug delivery systems; nanoparticle encapsulation; bioactive compound extraction; pharmaceutical purification; controlled release; sustainable pharmaceutical processes

(This special issue belongs to the Section Pharmaceutical Technology)

Computer-Aided Drug Design and Drug Discovery, 2nd Edition

edited by

Dragos Mihai

and

George Mihai Nitulescu

submission deadline 25 Sep 2025 | Viewed by 179 | Submission Open

Keywords: chemoinformatics; bioinformatics; molecular modeling; virtual screening; molecular docking; quantitative structure– activity relationship (QSAR); pharmacophore modeling; target identification; repurposing; ADME-T prediction

(This special issue belongs to the Section Medicinal Chemistry)

Recent Research in Therapeutic Potentials of Venoms

edited by Samuel Teixeira, Daiana Silva Lopes and

Sarah Natalie Cirilo Gimenes

submission deadline 25 Sep 2025 | Viewed by 146 | Submission Open

Keywords: bioprospecting; biotechnological tools; snake venom toxins; drug discovery; natural products; pharmacological applications; molecular targets of venom toxins; toxicology; peptide therapeutics; venom-based drug delivery

(This special issue belongs to the Section Natural Products)

Combating Drug Resistance in Cancer

edited by

Nina Rembiałkowska

and

Wojciech Szlasa

submission deadline 25 Sep 2025 | Viewed by 141 | Submission Open

Keywords: multidrug resistance; cancer cells; cancer drug resistance; overcoming chemoresistance; targeted cancer therapies; novel anti-cancer strategies; tumor resistance mechanisms; innovative cancer treatments; reversing drug resistance

(This special issue belongs to the Section Medicinal Chemistry)

Design, Synthesis and Evaluation of Novel 18F Radiotracers

edited by

Junfeng Li

and John E. Shively

submission deadline 25 Sep 2025 | Viewed by 92 | Submission Open

Keywords: positron emission tomography (PET); fluorine-18 (F-18); radiotracer development; molecular imaging; non-invasive diagnostic technique; synthetic methodologies; preclinical evaluation

(This special issue belongs to the Section Radiopharmaceutical Sciences)

Advances in Drug Analysis and Drug Development, 2nd Edition

edited by

Daniela Amidžić Klarić

and Ana Mornar

submission deadline 25 Sep 2025 | Viewed by 90 | Submission Open

Keywords: analytical methodology; chromatographic techniques; spectrometric techniques; thermal analysis techniques; sample preparation; drug stability; compatibility study; bioavailability studies; therapeutic drug monitoring; quality by design in pharmaceutical analysis

(This special issue belongs to the Section Pharmaceutical Technology)

Innovative Drug Strategies in Chronic Disease Management: Addressing Non-Adherence and Improving Therapeutic Outcomes

edited by

Eduardo Gutiérrez-Abejón

and

F. Javier Alvarez

submission deadline 26 Sep 2025 | 1 articles | Viewed by 606 | Submission Open

Keywords: adherence; persistence; chronic diseases; therapeutic strategies; individualized therapy; personalized medicine; clinical pharmacology; clinical trials; observational studies; real-world data studies

(This special issue belongs to the Section Pharmacology)

Innovative Drug Delivery Systems for Enhanced Dissolution and Bioavailability

edited by Marival Bermejo,

Paloma Marina De la Torre-Iglesias

and Covadonga Álvarez-Álvarez

submission deadline 26 Sep 2025 | Viewed by 164 | Submission Open

Keywords: drug dissolution enhancement; oral bioavailability improvement; poorly soluble drugs; solid dispersions; nanoparticle drug delivery; amorphous formulations; 3D printing in pharmaceuticals; advanced drug-polymer systems; advanced excipients for solubility enhancement; controlled drug release

(This special issue belongs to the Section Pharmaceutical Technology)

Computational Predictions of Molecules with Potential Therapeutic Effects

edited by

Whelton Miller

submission deadline 30 Sep 2025 | 6 articles | Viewed by 7777 | Submission Open

Keywords: biophysics; medicinal chemistry; drug discovery; molecular docking; molecular dynamics; structure-activity relationships; computer-aided drug design (CADD)

(This special issue belongs to the Section Medicinal Chemistry)

Recent Advances in Drug Metabolism, Transport, and Pharmacokinetics

edited by Agnieszka Bienert and

Joanna Bartkowiak-Wieczorek

submission deadline 30 Sep 2025 | 2 articles | Viewed by 4627 | Submission Open

Keywords: pharmacokinetic analysis; analytical methods suitable for pharmacokinetics studies; pharmacogenetics in drug pharmacokinetics; clinical pharmacokinetics; drug concentrations in plasma and tissue; population PK modeling; drug metabolic pathways; drug transport across barriers

(This special issue belongs to the Section Pharmacology)

Advances in Pharmacotherapy for Nasal Disorders in Rhinology

edited by

Elena Cantone

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1415 | Submission Open

Keywords: rhinology; CRS; asthma; nasal polyps; biologics; airflow; children; QoL; artificial intelligence; olfaction; chemical senses

(This special issue belongs to the Section Pharmacology)

Advances in Ophthalmic Drug Discovery and Delivery: From Targets to Treatments

edited by

Hongli Wu

submission deadline 30 Sep 2025 | 3 articles | Viewed by 1373 | Submission Open

Keywords: retinal degeneration; glaucoma; cataract; diabetic retinopathy; drug target; drug delivery; drug candidate; gene therapy; stem cells; natural products; Artificial Intelligence

(This special issue belongs to the Section Pharmacology)

Innovative Analytical Techniques and Nanotechnology in Natural Products Analysis and Drug Development

edited by Jinchao Wei and

Di Chen

submission deadline 30 Sep 2025 | Viewed by 353 | Submission Open

Keywords: natural product; Chinese medicine; drug development; analytical technique; nanotechnology; spectrometry; chromatography; sensors; formulation

(This special issue belongs to the Section Natural Products)

Effects of Drug Abuse and Its Consequences on Health

edited by

Diana Dias Da Silva

and

Marcelo Dutra Arbo

submission deadline 30 Sep 2025 | Viewed by 179 | Submission Open

Keywords: psychoactive substances; drug abuse; toxicological effects; neurotoxicity; substance use disorder; biomarkers of toxicity; public health impact; addiction mechanisms; harm reduction strategies; novel psychoactive substance (NPS)

(This special issue belongs to the Section Medicinal Chemistry)

Advancements and Possibilities for the Treatment of Idiopathic Inflammatory Myopathies

edited by

Jucier Gonçalves Júnior

and Samuel Katsuyuki Shinjo

submission deadline 30 Sep 2025 | Viewed by 140 | Submission Open

Keywords: anti-synthetase syndrome; dermatomyositis; polymyositis; inflammatory myopathy; myositis; treatment

(This special issue belongs to the Section Pharmacology)

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