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Pharmaceuticals publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Innovative Approaches to Radiopharmaceuticals: Advances in Design, Labeling, and Applications

edited by Shvan J. Raheem and

Justin J. Bailey

submission deadline 25 Mar 2026 | 3 articles | Viewed by 6362 | Submission Open

Keywords: radiochemistry; radiopharmaceutical; radiotracers

(This special issue belongs to the Section Radiopharmaceutical Sciences)

Cutting-Edge Biotechnologies and Applications of Natural Products in Drug R&D and Disease Treatment

edited by

Sujay Paul

submission deadline 25 Mar 2026 | 4 articles | Viewed by 5234 | Submission Open

Keywords: natural products; bioactive compounds; natural product drug discovery and drug design; natural drug formulation; metabolic engineering for bioactive compounds; natural therapeutic agents; nanoformulations of natural compounds; synthetic biology for natural product biosynthesis; genome editing and creation of novel bioactive compounds

(This special issue belongs to the Section Natural Products)

Pharmacological Activities of Flavonoids and Their Analogues, Third Edition

edited by

Fernando Calzada

and

Miguel Valdes

submission deadline 25 Mar 2026 | 3 articles | Viewed by 4505 | Submission Open

Keywords: natural products; polyphenols; flavonoids; medicinal chemistry; traditional medicine; flavonoids isolation; flavonoids identification; flavonoids pharmacology; flavonoids as prodrugs; in vivo; in vitro; and in silico studies; molecular modeling studies

(This special issue belongs to the Section Natural Products)

Immunogenomics for Drug Discovery in Leukemia

edited by

Silvia Jiménez-Morales

and Adolfo Martínez-Tovar

submission deadline 25 Mar 2026 | 1 articles | Viewed by 3101 | Submission Open

Keywords: leukemia; hematological diseases; immunogenomics; omics studies; experimental models; therapeutic approaches

(This special issue belongs to the Section Medicinal Chemistry)

Cholinergic Modulation, Anticholinergic Burden, and Neuroprotection: Mechanisms to Therapeutics

edited by

Ion Brinza

and

Lucian Hritcu

submission deadline 25 Mar 2026 | 2 articles | Viewed by 2983 | Submission Open

Keywords: scopolamine; anticholinergic burden; cholinergic modulation; cognitive impairment; neuroinflammation; oxidative stress; BBB/drug delivery; PK/PD; biomarkers; network pharmacology; flavonoids/polyphenols; zebrafish models; translational neuroscience; deprescribing

(This special issue belongs to the Section Pharmacology)

Metabolism, Inflammation and Neurodegeneration: Natural Compounds as Therapeutic Agents

edited by Pedro Cisternas

submission deadline 25 Mar 2026 | 3 articles | Viewed by 1886 | Submission Open

Keywords: neurodegenerative diseases; natural compounds; metabolic dysfunction; neuroinflammation; therapeutic strategies

(This special issue belongs to the Section Natural Products)

Advances in the Medicinal Synthesis of Bioactive Compounds

edited by

Iliyan Ivanov

and

Stanimir Manolov

submission deadline 25 Mar 2026 | 1 articles | Viewed by 1770 | Submission Open

Keywords: medicinal chemistry; bioactive compounds; synthetic methodologies; structure– activity relationship (SAR); drug discovery; pharmacokinetics; therapeutic agents; green chemistry; computational modeling; interdisciplinary research

(This special issue belongs to the Section Medicinal Chemistry)

Expanding the Cancer Drug Discovery Toolbox: A Focus on Protein Degradation, Allosteric Modulation, and Covalent Inhibition

edited by Rita Maria Concetta Di Martino and

Antonella Messore

submission deadline 25 Mar 2026 | 1 articles | Viewed by 1699 | Submission Open

Keywords: protein degradation; proteolysis targeting chimeras; hydrophobic tags; molecular glues; allosteric modulators; covalent inhibitors

(This special issue belongs to the Section Medicinal Chemistry)

Exploring Natural Products with Antioxidant and Anticancer Properties, 2nd Edition

edited by

Sikiru Olaitan Balogun

and

Edson Lucas Dos Santos

submission deadline 25 Mar 2026 | 2 articles | Viewed by 1064 | Submission Open

Keywords: antioxidant; anticancer; neoplasms; natural products; cytotoxicity

(This special issue belongs to the Section Natural Products)

Application of Supercritical Fluids in Pharmaceutical Science

edited by

Cecília I. A. V. Santos

submission deadline 25 Mar 2026 | 1 articles | Viewed by 936 | Submission Open

Keywords: supercritical fluids; scCO2; drug formulation; bioavailability; green chemistry; drug delivery systems; nanoparticle encapsulation; bioactive compound extraction; pharmaceutical purification; controlled release; sustainable pharmaceutical processes

(This special issue belongs to the Section Pharmaceutical Technology)

Organochalcogen Derivatives in Medicinal Chemistry

edited by Agata Pacuła-Miszewska and

Jacek Ścianowski

submission deadline 25 Mar 2026 | 1 articles | Viewed by 816 | Submission Open

Keywords: organochalcogens; modern organic synthesis; medicinal chemistry; biological activity

(This special issue belongs to the Section Medicinal Chemistry)

Essential Oil-Based Nanoemulsions

edited by Pinho Fernandes Fernandes

submission deadline 25 Mar 2026 | 1 articles | Viewed by 696 | Submission Open

Keywords: volatile oil; monoterpene; sesquiterpene; phenylpropanoid; dynamic light scattering

(This special issue belongs to the Section Pharmaceutical Technology)

Metal-Based Nanoparticles’ Biological Activity and Pharmaceutical Applications, 2nd Edition

edited by

Elitsa L. Pavlova

and

Debbie C. Crans

submission deadline 25 Mar 2026 | 1 articles | Viewed by 624 | Submission Open

Keywords: metal nanoparticles; redox reactions; biological activity; pharmaceuticals; cytotoxicity; antibacterial effect; oxidative stress; disease; safety; in vivo applications

(This special issue belongs to the Section Medicinal Chemistry)

Melatonin Applications in Pharmaceutical Science

edited by

Javier Menéndez-Menéndez

submission deadline 25 Mar 2026 | Viewed by 298 | Submission Open

Keywords: melatonin; pineal gland; epigenetics; pharmacology; physiology; immunology; pharmaceutics; novel therapies; cancer

(This special issue belongs to the Section Pharmacology)

Applications and Perspectives of Metal Chelators and Metal Complexes in Drug Development

edited by Joanna Izabela Lachowicz

submission deadline 25 Mar 2026 | Viewed by 269 | Submission Open

Keywords: metal chelators; metal complexes; drug development; cancer treatment; neurodegenerative disorder therapy; targeted drug delivery; metal-based nanomedicine; coordination chemistry in medicine; bioinorganic chemistry

(This special issue belongs to the Section Medicinal Chemistry)

Crystal Engineering in the Pharmaceutical Sciences

edited by

Stephen Robert Byrn

submission deadline 25 Mar 2026 | Viewed by 238 | Submission Open

Keywords: intermolecular interactions; cocrystals; salts; disproportionation; crystal structure prediction; space manufacturing

(This special issue belongs to the Section Medicinal Chemistry)

Novel Anti-Obesity Pharmacotherapies

edited by

Khanyisani Ziqubu

and

Zibele Ndlovu

submission deadline 25 Mar 2026 | Viewed by 202 | Submission Open

Keywords: obesity; anti-obesity pharmacotherapy; weight management; combination therapy; incretin-based polyagonists; amylin analogs; melanocortin receptor modulators; fibroblast growth factor mimetics; mitochondrial uncoupler; clinical efficacy; obesity-induced diseases

(This special issue belongs to the Section Pharmacology)

Kynurenine Pathway: A Novel Therapeutic Opportunity—2nd Edition

edited by

Verónica Pérez de la Cruz

Tonali Blanco-Ayala

and

Daniela Ramírez-Ortega

submission deadline 25 Mar 2026 | Viewed by 169 | Submission Open

Keywords: tryptophan catabolism; redox modulation; kynurenines; immunoregulation

(This special issue belongs to the Section Pharmacology)

Novel Vasoactive and Anti-Inflammatory Agents: From Mechanisms to Therapeutic Applications

edited by

Thyago Moreira De Queiroz

and Alice Valença Araújo

submission deadline 25 Mar 2026 | Viewed by 152 | Submission Open

Keywords: vasorelaxation; inflammation; oxidative stress; nitric oxide; natural and synthetic products; blood pressure

(This special issue belongs to the Section Pharmacology)

Pharmacotherapy and Molecular Biomarkers of Metabolic Diseases

edited by Kathleen F. Saavedra Peña and

Nicolás R. Saavedra Cuevas

submission deadline 25 Mar 2026 | Viewed by 147 | Submission Open

Keywords: molecular biomarkers; cardiovascular diseases; metabolic diseases; precision medicine; pharmacogenomics; translational research; omics technologies; drug response variability; personalized medicine

(This special issue belongs to the Section Pharmacology)

Advancements in Cardiovascular and Antidiabetic Drug Therapy, 2nd Edition

edited by

Alfredo Caturano

submission deadline 27 Mar 2026 | 15 articles | Viewed by 25114 | Submission Open

Keywords: cardiovascular diseases; antidiabetic drugs; pharmacological interventions; sodium– glucose cotransporter 2 inhibitors; PCSK9 inhibitors; obeticholic acid; lipid-lowering agents; heart failure treatment; diabetes management; drug therapy innovations

(This special issue belongs to the Section Pharmacology)

Therapeutic Applications of Micro-RNA in Cancer Management

edited by

Alma D. Campos-Parra

submission deadline 27 Mar 2026 | 2 articles | Viewed by 3686 | Submission Open

Keywords: cancer; miRNAs; therapeutic applications; miRNA treatments

(This special issue belongs to the Section Biopharmaceuticals)

Structural Insights into Protein Kinases-Targeted Therapies: Overcoming Resistance and Advancing Precision Oncology

edited by David Hecht

submission deadline 27 Mar 2026 | 2 articles | Viewed by 1854 | Submission Open

Keywords: protein kinases inhibitor resistance; structural biology of of protein kinases; computational modeling; drug design; preclinical and clinical studies; precision oncology; ALK resistance for personalized medicine

(This special issue belongs to the Section Medicinal Chemistry)

Identification and Extraction of Bioactive Compounds from Marine Life

edited by

Monde Mc Millan Ntwasa

and Wilfred T. Mabusela

submission deadline 27 Mar 2026 | 1 articles | Viewed by 569 | Submission Open

Keywords: natural products; marine life; bioactive compounds; cancer; antimicrobials

(This special issue belongs to the Section Natural Products)

Discovery and Validation of Novel Antimicrobial Molecules for the Treatment of Multidrug-Resistant Bacterial Infections

edited by

Paolo Gaibani

and Rocco Latorre

submission deadline 27 Mar 2026 | Viewed by 372 | Submission Open

Keywords: antibiotics therapy; multidrug resistance; bacterial infection

(This special issue belongs to the Section Pharmacology)

Innovative Drug Delivery Systems for Enhanced Dissolution and Bioavailability

edited by Marival Bermejo,

Paloma Marina De la Torre-Iglesias

and Covadonga Álvarez-Álvarez

submission deadline 27 Mar 2026 | Viewed by 367 | Submission Open

Keywords: drug dissolution enhancement; oral bioavailability improvement; poorly soluble drugs; solid dispersions; nanoparticle drug delivery; amorphous formulations; 3D printing in pharmaceuticals; advanced drug-polymer systems; advanced excipients for solubility enhancement; controlled drug release

(This special issue belongs to the Section Pharmaceutical Technology)

Molecular Systems for the Delivery of Drugs and Contrast Agents, 2nd Edition

edited by

Angelo Maspero

Luca Nardo

and

Marco Lamperti

submission deadline 27 Mar 2026 | 1 articles | Viewed by 146 | Submission Open

Keywords: biomarker-targeted drugs; contrast media for diagnostic imaging; drug delivery systems; photoactivated drugs and photoswitches; theranostics; liposomes; biomaterials-based drugs and drug shuttles (e.g.; DNA origami); biomimetic materials; nanoparticle applications to diagnostics and therapy; in silico drug design

(This special issue belongs to the Section Medicinal Chemistry)

Exploring the Anticancer and Immunomodulatory Mechanisms of Phytochemicals and Natural Bioactive Compounds

edited by Suyun Lyu

submission deadline 31 Mar 2026 | 9 articles | Viewed by 21703 | Submission Open

Keywords: natural products; phytochemicals; anticancer; immunomodulation; bioactive compounds

(This special issue belongs to the Section Pharmacology)

A Commemorative Special Issue in Honor of Professor Eliezer J. Barreiro: Early Drug Discovery: From Target Identification and Validation to Lead Optimization

edited by

Luzineide Tinoco

and

Lídia Lima

submission deadline 31 Mar 2026 | 4 articles | Viewed by 7167 | Submission Open

Keywords: target validation; LBDD; FBDD; SBDD; QSAR; artificial intelligence; organic synthesis; natural product; drug discovery; medicinal chemistry

(This special issue belongs to the Section Medicinal Chemistry)

Advances in Antiparasitic Drug Research

edited by

Andre Aires

and

Maria Cristiano

submission deadline 31 Mar 2026 | 3 articles | Viewed by 3927 | Submission Open

Keywords: antiparasitic drug; novel drug targets; parasite resistance; drug efficacy; parasite genetics

(This special issue belongs to the Section Pharmacology)

Recent Advances in Natural Product-Based Nanostructured Systems: 2nd Edition

edited by

Luís Alexandre Muehlmann

and

João Paulo Longo

submission deadline 31 Mar 2026 | 2 articles | Viewed by 3427 | Submission Open

Keywords: natural product; nanostructured systems; nanotechnology; nanostructures; nanocarriers; bioactive compounds

(This special issue belongs to the Section Natural Products)

Natural Product-Derived Treatments of Neurological and Neuropsychiatric Disorders

edited by

Cristiane S. F. Maia

Enéas A. Fontes-Júnior

Mozaniel Santana de Oliveira

and Jofre J. S. Freitas

submission deadline 31 Mar 2026 | 3 articles | Viewed by 2224 | Submission Open

Keywords: natural products; bioactive compounds; neurological conditions; psychiatric disorders; phytomedicine

Bioactive Compounds from Plants and Foods: From Traditional Medicine to Modern Applications in Nutrition and Health

edited by

Sendar Nery-Flores

Filiberto Gutierrez-Gutierrez

, Walter Trujillo-Rangel and

Raúl Rodríguez-Herrera

submission deadline 31 Mar 2026 | 1 articles | Viewed by 2212 | Submission Open

Keywords: herbal extracts; natural compounds; nutraceuticals; bioactive compounds; in vitro and in vivo studies; biological activities; phytochemistry; natural product drug discovery; computational screening of natural products; nanomaterials for natural product extraction

(This special issue belongs to the Section Natural Products)

Peptide-Based Drug Discovery: Innovations and Breakthroughs

edited by

Santo Previti

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1232 | Submission Open

Keywords: drug discovery; peptide-based compounds; peptidomimetics; target modulation; structure– activity relationship studies; hit molecules; AI-driven drug discovery; ligand-based drug design; structure-based drug design; computer-aided drug design

(This special issue belongs to the Section Medicinal Chemistry)

Antimicrobial and Anticancer Scaffolds in Medicinal Chemistry

edited by

Monika Pitucha

submission deadline 31 Mar 2026 | 1 articles | Viewed by 602 | Submission Open

Keywords: antimicrobial; anticancer; synthesis; complex; organic compounds; heterocyclic compounds; SAR

(This special issue belongs to the Section Medicinal Chemistry)

Synthesis and Biological Activity of Metal Complexes

edited by

Francois Dufrasne

submission deadline 31 Mar 2026 | Viewed by 395 | Submission Open

Keywords: metal complexes; biological activity; synthesis; pharmacology; cancer; pathogens; medicine; chemistry; stability; target

(This special issue belongs to the Section Medicinal Chemistry)

Advances in Small-Molecule Therapeutics Targeting Signaling Pathways

edited by

Arianna Gelain

submission deadline 31 Mar 2026 | Viewed by 269 | Submission Open

Keywords: small molecules; natural compounds; synthetic compounds; signaling pathways; drug design; drug development; HTS; computational tools; biological evaluations; QSAR; bioavailability; pharmacokinetics

(This special issue belongs to the Section Medicinal Chemistry)

Stem Cells in Oncology: Emerging Targets for Therapy

edited by

Ling Li

and

Umesh P Yadav

submission deadline 31 Mar 2026 | Viewed by 215 | Submission Open

Keywords: cancer stem cells (CSCs); tumor microenvironment (TME); targeted therapy; treatment resistance; biomarkers

(This special issue belongs to the Section Biopharmaceuticals)

Design, Synthesis and Pharmacological Evaluation of Novel Opioid/Non-Opioid Hybrid Compounds

edited by Justyna Piekielna-Ciesielska and

Katarzyna Gach-Janczak

submission deadline 31 Mar 2026 | Viewed by 144 | Submission Open

Keywords: opioid; opioid hybrids; pain; opioid-related side-effects; tolerance; addiction; neurotransmitters

(This special issue belongs to the Section Medicinal Chemistry)

Membrane Receptors in Disease: Mechanisms and Targeted Therapeutic Strategies

edited by

Robson Xavier Faria

submission deadline 31 Mar 2026 | Viewed by 80 | Submission Open

Keywords: membrane receptors; targeted drug; signal transduction; therapeutic antibodies; inhibitor; synthetic

(This special issue belongs to the Section Pharmacology)

Bioactive Natural Extracts: Advances in Pharmacological and Therapeutic Research

edited by

Gabriela-Maria Baci

and

Victorița Bonta

submission deadline 1 Apr 2026 | 1 articles | Viewed by 525 | Submission Open

Keywords: bioactive compounds; natural extracts; pharmacological activity; drug discovery; plant-derived compounds

(This special issue belongs to the Section Natural Products)

Advances in Ophthalmic Drug Discovery and Delivery: From Targets to Treatments

edited by

Hongli Wu

submission deadline 10 Apr 2026 | 4 articles | Viewed by 7093 | Submission Open

Keywords: retinal degeneration; glaucoma; cataract; diabetic retinopathy; drug target; drug delivery; drug candidate; gene therapy; stem cells; natural products; Artificial Intelligence

(This special issue belongs to the Section Pharmacology)

Emerging Therapeutics for the Prevention of Chemotherapy-Induced Cardiotoxicity: Advances and Future Perspectives

edited by

Luigi Spadafora

Marco Bernardi

, Sarto Sarto and

Vincenzo Quagliariello

submission deadline 20 Apr 2026 | 3 articles | Viewed by 7746 | Submission Open

Keywords: cardio-oncology; chemotherapy-induced cardiotoxicity; cardioprotective agents; biomarkers; heart failure prevention; precision medicine; pharmacological innovation; molecular targets; cancer survivorship; multidisciplinary care

(This special issue belongs to the Section Pharmacology)

Targeting Enzymes in Drug Design and Discovery

edited by

Mariyana Atanasova

submission deadline 20 Apr 2026 | 1 articles | Viewed by 331 | Submission Open

Keywords: drug design; computer-aided drug design (CADD); molecular docking; molecular dynamics; QSAR; druggable proteins; synthesis; in vitro and in vivo activity evaluations; ADMET predictions and evaluations

(This special issue belongs to the Section Biopharmaceuticals)

Next-Generation Targeted Therapy: vNARs as Drug Carriers and Intracellular Neutralizing Agents

edited by

Tanya Camacho-Villegas

and

Mirna Burciaga-Flores

submission deadline 20 Apr 2026 | Viewed by 270 | Submission Open

Keywords: vNAR; drug delivery; intrabodies; payload; nanotechnology; immunotoxins; phage display; biopanning; single-domain antibody

(This special issue belongs to the Section Pharmacology)

Biosimilars in Oncology: Applications in Pharmaceutics and Pharmaceuticals

edited by Jacopo Giuliani

submission deadline 20 Apr 2026 | Viewed by 84 | Submission Open

Keywords: biosimilars; oncology; randomized controlled trials; pharmacokinetics; pharmacodynamics

(This special issue belongs to the Section Biopharmaceuticals)

Design and Synthesis of Compounds with Potential Anti-Inflammatory Activity

edited by

Aleksandra Redzicka

Beata Tylińska

and Anna Wójcicka

submission deadline 22 Apr 2026 | Viewed by 198 | Submission Open

Keywords: drug design; synthesis; anti-inflammatory activity; cyclooxygenases; lipoxygenases; cytokines; anticancer activity; Alzheimer's disease; neuroinflammation; molecular mechanisms

(This special issue belongs to the Section Medicinal Chemistry)

Advanced Nanosystems and Emerging Therapies: Innovations in Tuberculosis Treatment and Drug Resistance

edited by

Fernando Rogério Pavan

and

Cesar Augusto Roque-Borda

submission deadline 24 Apr 2026 | 2 articles | Viewed by 3584 | Submission Open

Keywords: nanosystems; tuberculosis therapy; drug delivery; multidrug-resistant Mycobacterium tuberculosis (MDR-TB); nanotechnology-based therapeutics

(This special issue belongs to the Section Pharmaceutical Technology)

Use of Encapsulating Polymers of Active Compounds in the Pharmaceutical Industry

edited by Alba Adriana Vallejo-Cardona, Inocencio Higuera-Ciapara and

Janna Douda

submission deadline 24 Apr 2026 | 1 articles | Viewed by 3121 | Submission Open

Keywords: polymer; drug delivery; active compounds; encapsulation; pharmaceutical industry; natural polymers; synthetic polymers

(This special issue belongs to the Section Pharmaceutical Technology)

Medicinal Chemistry of Metal Complexes: Design, Synthesis and Evaluation

edited by

Bojana B. Zmejkovski

Goran Kaluđerović

and

Nebojša Pantelić

submission deadline 24 Apr 2026 | 1 articles | Viewed by 2711 | Submission Open

Keywords: metal complexes; medicinal chemistry; bioinorganic chemistry; coordination chemistry; organometallics; metal-based drugs; biological activity; toxicology; biomedical application; drug delivery

(This special issue belongs to the Section Medicinal Chemistry)

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