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Pharmaceuticals publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Triazole and Derivatives in Medicinal Chemistry, 2nd Edition

edited by Saeed Bahadorikhalili

submission deadline 15 Mar 2026 | Viewed by 401 | Submission Open

Keywords: triazole; heterocycles; medicinal chemistry; pharmaceutical chemistry; organic synthesis; catalytic organic synthesis; bioactivity; organocatalysis

(This special issue belongs to the Section Medicinal Chemistry)

Pharmaceutical Formulation Characterization Design, 2nd Edition

edited by

Katalin Kristó

and

Tamás Sovány

submission deadline 15 Mar 2026 | Viewed by 155 | Submission Open

Keywords: Quality by Design; factorial design; design space; solid dosage forms; risk assessment; critical process parameters; quality target product profile

(This special issue belongs to the Section Pharmaceutical Technology)

Natural Products for Therapeutic Potential

edited by

Xavier Siwe Noundou

submission deadline 20 Mar 2026 | 6 articles | Viewed by 28898 | Submission Open

Keywords: natural products chemistry; therapeutic potential; medicinal plants; marine organisms; microorganisms; bioactive compounds; natural products inspired compounds; biological activities; computational chemistry

(This special issue belongs to the Section Natural Products)

Natural Pharmacons: Biologically Active Plant-Based Pharmaceuticals—4th Edition

edited by

Dejan Stojković

and

Marina Soković

submission deadline 20 Mar 2026 | 8 articles | Viewed by 10348 | Submission Open

Keywords: chemical characterization of natural preparations; therapeutic potential of natural matrices in cardiovascular diseases; diabetes; cancer; and neurodegenerative diseases; antimicrobial activity; antioxidant activity; anti-enzymatic activity; anti-inflammatory activity; mechanism of pharmacological actions; structure– activity relationship studies

(This special issue belongs to the Section Natural Products)

Potential Pharmacotherapeutic Targets in Neurodegenerative Diseases

edited by

Cláudio Viegas-Junior

submission deadline 20 Mar 2026 | 2 articles | Viewed by 6762 | Submission Open

Keywords: neurodegenerative diseases; neuroinflammation; neuroprotection; molecular targets; therapeutic drugs

(This special issue belongs to the Section Pharmacology)

Natural Antioxidants from Medicinal Plants: Extraction and Bioactivity

edited by

Julio Escalona-Arranz

and

Jesús García-Díaz

submission deadline 20 Mar 2026 | Viewed by 227 | Submission Open

Keywords: natural antioxidants; medicinal plants; extraction methods; bioactivity; phenolic compounds; free radical scavenging; pharmacological potential; in silico and in vitro correlation; molecular modeling

(This special issue belongs to the Section Natural Products)

Novel Therapeutic Targets in the Cardiovascular Treatment Landscape

edited by Weida Wu and

Nikolaos Kadoglou

submission deadline 22 Mar 2026 | 2 articles | Viewed by 1109 | Submission Open

Keywords: cardiovascular disease; novel therapeutic targets; lipid metabolism; cardiac fibrosis and remodeling; inflammation and immune modulation; Lp(a); heart failure; RNA therapeutics; precision cardiology; cardiomyopathy

(This special issue belongs to the Section Pharmacology)

Medicinal Plants: Exploring Plant-Based Bioactive Compounds for Cancer and Metabolic Diseases Prevention and Intervention

edited by

Lucas Fornari Laurindo

and

Sandra Barbalho

submission deadline 25 Mar 2026 | 4 articles | Viewed by 14918 | Submission Open

Keywords: cancer; metastasis; tumor growth; tumor spread; bioactive compounds; phytochemicals; medicinal plants; phytochemistry; cancer prevention; cancer intervention; metabolic diseases; metabolism; diabetes; MAFLD; dyslipidemia

(This special issue belongs to the Section Natural Products)

Molecular Mechanisms and Treatment of Brain Cancer: Recent Advances and Future Trends

edited by

Terezia Kiskova-Simkova

submission deadline 25 Mar 2026 | 5 articles | Viewed by 10756 | Submission Open

Keywords: brain cancer; molecular mechanism; treatment; diagnosis; in vitro; in vivo; models

(This special issue belongs to the Section Pharmacology)

Drug Treatment of Thyroid Cancer

edited by

Cristina Alina Silaghi

Carmen Emanuela Georgescu

Horaţiu Silaghi

and

Cristina Pop

submission deadline 25 Mar 2026 | 3 articles | Viewed by 9780 | Submission Open

Keywords: differentiated thyroid cancer; medullary thyroid cancer; anaplastic thyroid carcinoma; advanced/metastatic thyroid cancer; refractory thyroid cancer; targeted therapy in thyroid cancer; tyrosine kinase inhibitors; immune checkpoint inhibitors; redifferentiation treatment; drug resistance

Advances in Prostate Cancer Therapeutics

edited by

David Danielpour

submission deadline 25 Mar 2026 | 4 articles | Viewed by 7704 | Submission Open

Keywords: prostate cancer; androgen deprivation therapy (ADT); castration-resistant prostate cancer (CRPC); androgen receptor signaling inhibitors; PARP inhibitors; ionizing radiation therapy; radiopharmaceuticals; immunotherapy; biomarkers; personalized medicine; therapeutic resistance; targeted therapy; combination therapy; hormone-sensitive prostate cancer (HSPC); next-generation therapeutics; translational oncology

(This special issue belongs to the Section Pharmacology)

Challenges in Discovering Innovations Related to Biofilms: Virulence, Spread, Control Strategies and Treatment

edited by

Tsvetelina Paunova-Krasteva

submission deadline 25 Mar 2026 | 7 articles | Viewed by 6777 | Submission Open

Keywords: biofilm; structure; pathogenesis; virulence; tolerance; biofilm infections; dispersion; control strategies; quorum sensing

(This special issue belongs to the Section Pharmacology)

Innovative Approaches to Radiopharmaceuticals: Advances in Design, Labeling, and Applications

edited by Shvan J. Raheem and

Justin J. Bailey

submission deadline 25 Mar 2026 | 3 articles | Viewed by 6243 | Submission Open

Keywords: radiochemistry; radiopharmaceutical; radiotracers

(This special issue belongs to the Section Radiopharmaceutical Sciences)

Cutting-Edge Biotechnologies and Applications of Natural Products in Drug R&D and Disease Treatment

edited by

Sujay Paul

submission deadline 25 Mar 2026 | 3 articles | Viewed by 4713 | Submission Open

Keywords: natural products; bioactive compounds; natural product drug discovery and drug design; natural drug formulation; metabolic engineering for bioactive compounds; natural therapeutic agents; nanoformulations of natural compounds; synthetic biology for natural product biosynthesis; genome editing and creation of novel bioactive compounds

(This special issue belongs to the Section Natural Products)

Pharmacological Activities of Flavonoids and Their Analogues, Third Edition

edited by

Fernando Calzada

and

Miguel Valdes

submission deadline 25 Mar 2026 | 3 articles | Viewed by 4397 | Submission Open

Keywords: natural products; polyphenols; flavonoids; medicinal chemistry; traditional medicine; flavonoids isolation; flavonoids identification; flavonoids pharmacology; flavonoids as prodrugs; in vivo; in vitro; and in silico studies; molecular modeling studies

(This special issue belongs to the Section Natural Products)

Immunogenomics for Drug Discovery in Leukemia

edited by

Silvia Jiménez-Morales

and Adolfo Martínez-Tovar

submission deadline 25 Mar 2026 | 1 articles | Viewed by 3045 | Submission Open

Keywords: leukemia; hematological diseases; immunogenomics; omics studies; experimental models; therapeutic approaches

(This special issue belongs to the Section Medicinal Chemistry)

Cholinergic Modulation, Anticholinergic Burden, and Neuroprotection: Mechanisms to Therapeutics

edited by

Ion Brinza

and

Lucian Hritcu

submission deadline 25 Mar 2026 | 2 articles | Viewed by 2873 | Submission Open

Keywords: scopolamine; anticholinergic burden; cholinergic modulation; cognitive impairment; neuroinflammation; oxidative stress; BBB/drug delivery; PK/PD; biomarkers; network pharmacology; flavonoids/polyphenols; zebrafish models; translational neuroscience; deprescribing

(This special issue belongs to the Section Pharmacology)

Metabolism, Inflammation and Neurodegeneration: Natural Compounds as Therapeutic Agents

edited by Pedro Cisternas

submission deadline 25 Mar 2026 | 3 articles | Viewed by 1691 | Submission Open

Keywords: neurodegenerative diseases; natural compounds; metabolic dysfunction; neuroinflammation; therapeutic strategies

(This special issue belongs to the Section Natural Products)

Advances in the Medicinal Synthesis of Bioactive Compounds

edited by

Iliyan Ivanov

and

Stanimir Manolov

submission deadline 25 Mar 2026 | 1 articles | Viewed by 1683 | Submission Open

Keywords: medicinal chemistry; bioactive compounds; synthetic methodologies; structure– activity relationship (SAR); drug discovery; pharmacokinetics; therapeutic agents; green chemistry; computational modeling; interdisciplinary research

(This special issue belongs to the Section Medicinal Chemistry)

Expanding the Cancer Drug Discovery Toolbox: A Focus on Protein Degradation, Allosteric Modulation, and Covalent Inhibition

edited by Rita Maria Concetta Di Martino and

Antonella Messore

submission deadline 25 Mar 2026 | 1 articles | Viewed by 1673 | Submission Open

Keywords: protein degradation; proteolysis targeting chimeras; hydrophobic tags; molecular glues; allosteric modulators; covalent inhibitors

(This special issue belongs to the Section Medicinal Chemistry)

Exploring Natural Products with Antioxidant and Anticancer Properties, 2nd Edition

edited by

Sikiru Olaitan Balogun

and

Edson Lucas Dos Santos

submission deadline 25 Mar 2026 | 2 articles | Viewed by 973 | Submission Open

Keywords: antioxidant; anticancer; neoplasms; natural products; cytotoxicity

(This special issue belongs to the Section Natural Products)

Application of Supercritical Fluids in Pharmaceutical Science

edited by

Cecília I. A. V. Santos

submission deadline 25 Mar 2026 | 1 articles | Viewed by 874 | Submission Open

Keywords: supercritical fluids; scCO2; drug formulation; bioavailability; green chemistry; drug delivery systems; nanoparticle encapsulation; bioactive compound extraction; pharmaceutical purification; controlled release; sustainable pharmaceutical processes

(This special issue belongs to the Section Pharmaceutical Technology)

Organochalcogen Derivatives in Medicinal Chemistry

edited by Agata Pacuła-Miszewska and

Jacek Ścianowski

submission deadline 25 Mar 2026 | 1 articles | Viewed by 757 | Submission Open

Keywords: organochalcogens; modern organic synthesis; medicinal chemistry; biological activity

(This special issue belongs to the Section Medicinal Chemistry)

Essential Oil-Based Nanoemulsions

edited by Pinho Fernandes Fernandes

submission deadline 25 Mar 2026 | 1 articles | Viewed by 631 | Submission Open

Keywords: volatile oil; monoterpene; sesquiterpene; phenylpropanoid; dynamic light scattering

(This special issue belongs to the Section Pharmaceutical Technology)

Metal-Based Nanoparticles’ Biological Activity and Pharmaceutical Applications, 2nd Edition

edited by

Elitsa L. Pavlova

and

Debbie C. Crans

submission deadline 25 Mar 2026 | 1 articles | Viewed by 532 | Submission Open

Keywords: metal nanoparticles; redox reactions; biological activity; pharmaceuticals; cytotoxicity; antibacterial effect; oxidative stress; disease; safety; in vivo applications

(This special issue belongs to the Section Medicinal Chemistry)

Melatonin Applications in Pharmaceutical Science

edited by

Javier Menéndez-Menéndez

submission deadline 25 Mar 2026 | Viewed by 287 | Submission Open

Keywords: melatonin; pineal gland; epigenetics; pharmacology; physiology; immunology; pharmaceutics; novel therapies; cancer

(This special issue belongs to the Section Pharmacology)

Applications and Perspectives of Metal Chelators and Metal Complexes in Drug Development

edited by Joanna Izabela Lachowicz

submission deadline 25 Mar 2026 | Viewed by 250 | Submission Open

Keywords: metal chelators; metal complexes; drug development; cancer treatment; neurodegenerative disorder therapy; targeted drug delivery; metal-based nanomedicine; coordination chemistry in medicine; bioinorganic chemistry

(This special issue belongs to the Section Medicinal Chemistry)

Crystal Engineering in the Pharmaceutical Sciences

edited by

Stephen Robert Byrn

submission deadline 25 Mar 2026 | Viewed by 235 | Submission Open

Keywords: intermolecular interactions; cocrystals; salts; disproportionation; crystal structure prediction; space manufacturing

(This special issue belongs to the Section Medicinal Chemistry)

Novel Anti-Obesity Pharmacotherapies

edited by

Khanyisani Ziqubu

and

Zibele Ndlovu

submission deadline 25 Mar 2026 | Viewed by 196 | Submission Open

Keywords: obesity; anti-obesity pharmacotherapy; weight management; combination therapy; incretin-based polyagonists; amylin analogs; melanocortin receptor modulators; fibroblast growth factor mimetics; mitochondrial uncoupler; clinical efficacy; obesity-induced diseases

(This special issue belongs to the Section Pharmacology)

Kynurenine Pathway: A Novel Therapeutic Opportunity—2nd Edition

edited by

Verónica Pérez de la Cruz

Tonali Blanco-Ayala

and

Daniela Ramírez-Ortega

submission deadline 25 Mar 2026 | Viewed by 153 | Submission Open

Keywords: tryptophan catabolism; redox modulation; kynurenines; immunoregulation

(This special issue belongs to the Section Pharmacology)

Novel Vasoactive and Anti-Inflammatory Agents: From Mechanisms to Therapeutic Applications

edited by

Thyago Moreira De Queiroz

and Alice Valença Araújo

submission deadline 25 Mar 2026 | Viewed by 144 | Submission Open

Keywords: vasorelaxation; inflammation; oxidative stress; nitric oxide; natural and synthetic products; blood pressure

(This special issue belongs to the Section Pharmacology)

Pharmacotherapy and Molecular Biomarkers of Metabolic Diseases

edited by Kathleen F. Saavedra Peña and

Nicolás R. Saavedra Cuevas

submission deadline 25 Mar 2026 | Viewed by 137 | Submission Open

Keywords: molecular biomarkers; cardiovascular diseases; metabolic diseases; precision medicine; pharmacogenomics; translational research; omics technologies; drug response variability; personalized medicine

(This special issue belongs to the Section Pharmacology)

Advancements in Cardiovascular and Antidiabetic Drug Therapy, 2nd Edition

edited by

Alfredo Caturano

submission deadline 27 Mar 2026 | 15 articles | Viewed by 24425 | Submission Open

Keywords: cardiovascular diseases; antidiabetic drugs; pharmacological interventions; sodium– glucose cotransporter 2 inhibitors; PCSK9 inhibitors; obeticholic acid; lipid-lowering agents; heart failure treatment; diabetes management; drug therapy innovations

(This special issue belongs to the Section Pharmacology)

Therapeutic Applications of Micro-RNA in Cancer Management

edited by

Alma D. Campos-Parra

submission deadline 27 Mar 2026 | 2 articles | Viewed by 3632 | Submission Open

Keywords: cancer; miRNAs; therapeutic applications; miRNA treatments

(This special issue belongs to the Section Biopharmaceuticals)

Structural Insights into Protein Kinases-Targeted Therapies: Overcoming Resistance and Advancing Precision Oncology

edited by David Hecht

submission deadline 27 Mar 2026 | 2 articles | Viewed by 1773 | Submission Open

Keywords: protein kinases inhibitor resistance; structural biology of of protein kinases; computational modeling; drug design; preclinical and clinical studies; precision oncology; ALK resistance for personalized medicine

(This special issue belongs to the Section Medicinal Chemistry)

Identification and Extraction of Bioactive Compounds from Marine Life

edited by

Monde Mc Millan Ntwasa

and Wilfred T. Mabusela

submission deadline 27 Mar 2026 | 1 articles | Viewed by 483 | Submission Open

Keywords: natural products; marine life; bioactive compounds; cancer; antimicrobials

(This special issue belongs to the Section Natural Products)

Discovery and Validation of Novel Antimicrobial Molecules for the Treatment of Multidrug-Resistant Bacterial Infections

edited by

Paolo Gaibani

and Rocco Latorre

submission deadline 27 Mar 2026 | Viewed by 365 | Submission Open

Keywords: antibiotics therapy; multidrug resistance; bacterial infection

(This special issue belongs to the Section Pharmacology)

Innovative Drug Delivery Systems for Enhanced Dissolution and Bioavailability

edited by Marival Bermejo,

Paloma Marina De la Torre-Iglesias

and Covadonga Álvarez-Álvarez

submission deadline 27 Mar 2026 | Viewed by 349 | Submission Open

Keywords: drug dissolution enhancement; oral bioavailability improvement; poorly soluble drugs; solid dispersions; nanoparticle drug delivery; amorphous formulations; 3D printing in pharmaceuticals; advanced drug-polymer systems; advanced excipients for solubility enhancement; controlled drug release

(This special issue belongs to the Section Pharmaceutical Technology)

Molecular Systems for the Delivery of Drugs and Contrast Agents, 2nd Edition

edited by

Angelo Maspero

Luca Nardo

and

Marco Lamperti

submission deadline 27 Mar 2026 | Viewed by 128 | Submission Open

Keywords: biomarker-targeted drugs; contrast media for diagnostic imaging; drug delivery systems; photoactivated drugs and photoswitches; theranostics; liposomes; biomaterials-based drugs and drug shuttles (e.g.; DNA origami); biomimetic materials; nanoparticle applications to diagnostics and therapy; in silico drug design

(This special issue belongs to the Section Medicinal Chemistry)

Exploring the Anticancer and Immunomodulatory Mechanisms of Phytochemicals and Natural Bioactive Compounds

edited by Suyun Lyu

submission deadline 31 Mar 2026 | 8 articles | Viewed by 21290 | Submission Open

Keywords: natural products; phytochemicals; anticancer; immunomodulation; bioactive compounds

(This special issue belongs to the Section Pharmacology)

A Commemorative Special Issue in Honor of Professor Eliezer J. Barreiro: Early Drug Discovery: From Target Identification and Validation to Lead Optimization

edited by

Luzineide Tinoco

and

Lídia Lima

submission deadline 31 Mar 2026 | 4 articles | Viewed by 6941 | Submission Open

Keywords: target validation; LBDD; FBDD; SBDD; QSAR; artificial intelligence; organic synthesis; natural product; drug discovery; medicinal chemistry

(This special issue belongs to the Section Medicinal Chemistry)

Advances in Antiparasitic Drug Research

edited by

Andre Aires

and

Maria Cristiano

submission deadline 31 Mar 2026 | 3 articles | Viewed by 3837 | Submission Open

Keywords: antiparasitic drug; novel drug targets; parasite resistance; drug efficacy; parasite genetics

(This special issue belongs to the Section Pharmacology)

Recent Advances in Natural Product-Based Nanostructured Systems: 2nd Edition

edited by

Luís Alexandre Muehlmann

and

João Paulo Longo

submission deadline 31 Mar 2026 | 2 articles | Viewed by 3292 | Submission Open

Keywords: natural product; nanostructured systems; nanotechnology; nanostructures; nanocarriers; bioactive compounds

(This special issue belongs to the Section Natural Products)

Natural Product-Derived Treatments of Neurological and Neuropsychiatric Disorders

edited by

Cristiane S. F. Maia

Enéas A. Fontes-Júnior

Mozaniel Santana de Oliveira

and Jofre J. S. Freitas

submission deadline 31 Mar 2026 | 3 articles | Viewed by 2116 | Submission Open

Keywords: natural products; bioactive compounds; neurological conditions; psychiatric disorders; phytomedicine

Bioactive Compounds from Plants and Foods: From Traditional Medicine to Modern Applications in Nutrition and Health

edited by

Sendar Nery-Flores

Filiberto Gutierrez-Gutierrez

, Walter Trujillo-Rangel and

Raúl Rodríguez-Herrera

submission deadline 31 Mar 2026 | 1 articles | Viewed by 2078 | Submission Open

Keywords: herbal extracts; natural compounds; nutraceuticals; bioactive compounds; in vitro and in vivo studies; biological activities; phytochemistry; natural product drug discovery; computational screening of natural products; nanomaterials for natural product extraction

(This special issue belongs to the Section Natural Products)

Peptide-Based Drug Discovery: Innovations and Breakthroughs

edited by

Santo Previti

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1186 | Submission Open

Keywords: drug discovery; peptide-based compounds; peptidomimetics; target modulation; structure– activity relationship studies; hit molecules; AI-driven drug discovery; ligand-based drug design; structure-based drug design; computer-aided drug design

(This special issue belongs to the Section Medicinal Chemistry)

Antimicrobial and Anticancer Scaffolds in Medicinal Chemistry

edited by

Monika Pitucha

submission deadline 31 Mar 2026 | 1 articles | Viewed by 546 | Submission Open

Keywords: antimicrobial; anticancer; synthesis; complex; organic compounds; heterocyclic compounds; SAR

(This special issue belongs to the Section Medicinal Chemistry)

Synthesis and Biological Activity of Metal Complexes

edited by

Francois Dufrasne

submission deadline 31 Mar 2026 | Viewed by 384 | Submission Open

Keywords: metal complexes; biological activity; synthesis; pharmacology; cancer; pathogens; medicine; chemistry; stability; target

(This special issue belongs to the Section Medicinal Chemistry)

Advances in Small-Molecule Therapeutics Targeting Signaling Pathways

edited by

Arianna Gelain

submission deadline 31 Mar 2026 | Viewed by 256 | Submission Open

Keywords: small molecules; natural compounds; synthetic compounds; signaling pathways; drug design; drug development; HTS; computational tools; biological evaluations; QSAR; bioavailability; pharmacokinetics

(This special issue belongs to the Section Medicinal Chemistry)

Stem Cells in Oncology: Emerging Targets for Therapy

edited by

Ling Li

and

Umesh P Yadav

submission deadline 31 Mar 2026 | Viewed by 204 | Submission Open

Keywords: cancer stem cells (CSCs); tumor microenvironment (TME); targeted therapy; treatment resistance; biomarkers

(This special issue belongs to the Section Biopharmaceuticals)

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