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Pharmaceuticals publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Mass Spectrometry Metrology in Pharmaceutical Sciences

edited by Andrew P. Bowman and Rob J. Vreeken

submission deadline 25 Nov 2024 | 3 articles | Viewed by 3446 | Submission Open

Keywords: analytical standards; calibration; quality control; reference materials; validation; impurities; stability; traceability; analytical methods; drug analysis

(This special issue belongs to the Section Pharmacology)

Design and Synthesis of Small Molecule Kinase Inhibitors

edited by

Camilla Pecoraro

and

Daniela Carbone

submission deadline 25 Nov 2024 | 2 articles | Viewed by 3274 | Submission Open

Keywords: protein kinases; cancer; small molecule kinase inhibitors; heterocyclic compounds; cancer resistance; targeted therapy; cancer-altered pathway; genetic mutations; FDA-approved kinase inhibitors; kinase inhibitors combinations

(This special issue belongs to the Section Medicinal Chemistry)

Dopamine and Serotonin Receptors: Selective or Multitarget Ligands for the Treatment of Central Nervous System Diseases

edited by

Fabio Del Bello

and Wilma Quaglia

submission deadline 25 Nov 2024 | 2 articles | Viewed by 3249 | Submission Open

Keywords: dopamine and serotonin neurotransmission; selective dopamine receptor ligands; selective serotonin receptor ligands; multitarget agents; central nervous system pathologies; psychiatric disorders; neurodegenerative diseases

(This special issue belongs to the Section Pharmacology)

Solubilization and Controlled Release Strategy of Poorly Water-Soluble Drugs 2024

edited by

María Ángeles Peña Fernández

submission deadline 25 Nov 2024 | 2 articles | Viewed by 2160 | Submission Open

Keywords: drug formulation; solubilization; controlled release systems; solubility; poor water-soluble drugs

(This special issue belongs to the Section Pharmaceutical Technology)

Therapeutic Potential of Natural Products in Urolithiasis

edited by

Priscila de Souza

submission deadline 25 Nov 2024 | 2 articles | Viewed by 2148 | Submission Open

Keywords: natural products; plant extracts; isolated compounds from medicinal plants; kidney stone; nephrolithiasis; urinary tract; hypertension; diabetes; pain relievers

(This special issue belongs to the Section Natural Products)

Amyloid Composition and Structure-Based Development of Therapeutic and Diagnostic Agents

edited by Emily B. Martin and Jonathan S. Wall

submission deadline 25 Nov 2024 | 2 articles | Viewed by 2034 | Submission Open

(This special issue belongs to the Section Medicinal Chemistry)

Pharmacotherapy for Retinopathy

edited by Eric Shrier

submission deadline 25 Nov 2024 | 1 articles | Viewed by 2008 | Submission Open

Keywords: retinopathy of prematurity; ROP; anti-VEGF; HIF; pathologic neovascularization; OIR

(This special issue belongs to the Section Pharmacology)

Discovery of Natural Products as Potential Antidiabetic Agents

edited by

Fernando Calzada

and

Miguel Valdes

submission deadline 25 Nov 2024 | 1 articles | Viewed by 1524 | Submission Open

Keywords: diabetes mellitus; diabetes complications; glucosidase inhibitors; antidiabetic agents; molecular mechanism; new drug development; pharmacology; molecular docking assays

(This special issue belongs to the Section Medicinal Chemistry)

In Vivo Nuclear Molecular Imaging in Drug Development and Pharmacological Research: New Advances

edited by Haitao Wu and

Noriko Sato

submission deadline 25 Nov 2024 | 1 articles | Viewed by 1262 | Submission Open

Keywords: in vivo nuclear imaging; biomarker imaging; molecular imaging; PET; SPECT; pharmacokinetics; personalized medicine; drug development; molecular pathway

(This special issue belongs to the Section Radiopharmaceutical Sciences)

Smooth Muscle and Endothelial Cells as Pharmacological Targets for Acute Oxidative Stress

edited by Charles E. Norton

submission deadline 25 Nov 2024 | 1 articles | Viewed by 903 | Submission Open

Keywords: reactive oxygen species; oxidative stress; smooth muscle cells; endothelium; ischemia/reperfusion; stroke; myocardial infarction; traumatic brain injury

(This special issue belongs to the Section Pharmacology)

Exploring Biomarkers and Pharmacotherapies for Substance Use Disorders

edited by

Ani Gasparyan

Daniela Navarro

and

Jorge Manzanares

submission deadline 25 Nov 2024 | 1 articles | Viewed by 859 | Submission Open

(This special issue belongs to the Section Pharmacology)

Prodrugs: Design and Development

edited by

Viktor Reshetnikov

and

Chung Man Chin

submission deadline 25 Nov 2024 | Viewed by 507 | Submission Open

Keywords: prodrug; molecular modification; disease-specific activation; targeting; solubility and lipophilicity adjustment

(This special issue belongs to the Section Medicinal Chemistry)

Phytotherapeutic Applications in Colorectal Cancer (CRC) Management

edited by

Bence Raposa

and

John M. Macharia

submission deadline 25 Nov 2024 | Viewed by 282 | Submission Open

Keywords: colorectal; cancer; gene therapy; drug development; treatment; pathway

Pharmacoepidemiology and Pharmacovigilance in Drug Therapy: New Issues, Challenges, and Applications

edited by Loreta Kubilienė

submission deadline 25 Nov 2024 | Viewed by 229 | Submission Open

Keywords: pharmacoepidemiology; pharmacovigilance; drug safety monitoring; regulatory practices; hospitalization; adverse drug events; drug safety; preventability

(This special issue belongs to the Section Pharmacology)

Ion Channels as Pharmacological Targets in Cancer

edited by

Concetta Altamura

Ilaria Saltarella

and

Ester Pagano

submission deadline 25 Nov 2024 | Viewed by 189 | Submission Open

Keywords: ion channels; cancer; cancer pharmacology; target therapies; personalized therapy; chemoresistance; oncology; channelopathies

(This special issue belongs to the Section Pharmacology)

Molecular Systems for the Delivery of Drugs and Contrast Agents

edited by

Luca Nardo

Angelo Maspero

and

Mauro Fasano

submission deadline 28 Nov 2024 | 9 articles | Viewed by 19671 | Submission Open

Keywords: biomarker-targeted drugs; contrast media for diagnostic imaging; drug delivery systems; photoactivated drugs and photoswitches; theranostics; liposomes; biomaterials-based drugs and drug shuttles (e.g.; DNA origami); biomimetic materials; nanoparticle applications to diagnostics and therapy; in silico drug design

(This special issue belongs to the Section Medicinal Chemistry)

Toxicological Effects of Drug Abuse and Its Consequences on Health

edited by

Cristiane S. F. Maia

Enéas A. Fontes-Júnior

and

Rafael R. Lima

submission deadline 28 Nov 2024 | 2 articles | Viewed by 4856 | Submission Open

Keywords: addiction; drug abuse; toxicology; treatment; bioactive compound

(This special issue belongs to the Section Pharmacology)

Application of Gastrointestinal Peptides in Medicine

edited by

Predrag Sikirić

Sven Seiwerth

and Anita Škrtić

submission deadline 29 Nov 2024 | 1 articles | Viewed by 1519 | Submission Open

Keywords: brain– gut axes; gut peptides; gut peptide therapy; peptides; healing; heart failure

(This special issue belongs to the Section Pharmacology)

Recent Advances in TGF-β Inhibitors for the Therapeutic Management of Cancer and Fibrosis

edited by

David Danielpour

submission deadline 30 Nov 2024 | 8 articles | Viewed by 27576 | Submission Open

Keywords: TGF-β ; metastasis; EMT; immunotherapy; fibrosis; Smad2; Smad3; angiogenesis; ligand traps; soluble receptors

(This special issue belongs to the Section Pharmacology)

Network Pharmacology of Natural Products

edited by

Alexander George Panossian

submission deadline 30 Nov 2024 | 7 articles | Viewed by 14606 | Submission Open

Keywords: natural compounds; plant extracts; structure-activity relationship; network pharmacology; multitarget effects; synergy of complex preparations; pleiotropic activity

(This special issue belongs to the Section Natural Products)

Therapeutic Potential of Silver Nanoparticles (AgNPs)

edited by

Goreti Pereira

submission deadline 30 Nov 2024 | 9 articles | Viewed by 10968 | Submission Open

Keywords: metallic nanostructures; plasmonic nanomaterials; photothermal therapy; photodynamic therapy; antimicrobial; antioxidant; anticancer

(This special issue belongs to the Section Medicinal Chemistry)

Pharmacognosy and Phytotherapy: Natural Compounds from an Anti-aging Perspective 2024

edited by

Geir Bjørklund

Mariia Shanaida

and

Olha Mykhailenko

submission deadline 30 Nov 2024 | 4 articles | Viewed by 8940 | Submission Open

Keywords: senescence; anti-aging compounds; natural products; medicinal plants; micronutrients; cosmetic ingredients; bioactive natural substances; antioxidant activity; pharmacological effect

(This special issue belongs to the Section Natural Products)

Magnetic Nanoparticles (MNPs) in Biomedical Applications

edited by

Sandile Phinda Songca

submission deadline 30 Nov 2024 | 3 articles | Viewed by 8749 | Submission Open

Keywords: magnetic nanoparticles; magnetic resonance imaging; magnetic hyperthermia; cancer therapy; bone therapy; magnetically targeted drug delivery; magnetic hyperthermia drug release; antimicrobial; tissue engineering; biosensors

(This special issue belongs to the Section Pharmaceutical Technology)

Potential Therapeutic Targets for the Treatment of Pathological Pain

edited by

Sara Marchesan De Oliveira

submission deadline 30 Nov 2024 | 2 articles | Viewed by 8330 | Submission Open

Keywords: analgesics; pathological pain models; inflammation; rheumatoid arthritis; neuropathy; nerve injuries; spinal cord injuries; antineoplastics; headaches; irritable bowel syndrome; fibromyalgia

(This special issue belongs to the Section Pharmacology)

Nitrogen Containing Scaffolds in Medicinal Chemistry 2023

edited by

Valentina Noemi Madia

and Valeria Tudino

submission deadline 30 Nov 2024 | 5 articles | Viewed by 7925 | Submission Open

Keywords: nitrogen-based heterocycles; bioactive compounds; structure-based drug design; structure-activity relationship; in silico studies; ADMET properties; microwave-assisted synthesis; green chemistry; multicomponent reactions; phytochemicals

(This special issue belongs to the Section Medicinal Chemistry)

Antiradical, Chemopreventive and Antimicrobial Effects of Bioactive Natural Substances

edited by

Grażyna Zgórka

submission deadline 30 Nov 2024 | 4 articles | Viewed by 6867 | Submission Open

Keywords: natural radical scavengers; chemopreventive agents; antimicrobials; chemical and biomedical analysis; biological studies in vitro/in vivo

(This special issue belongs to the Section Natural Products)

HIV and Viral Hepatitis: Prevention, Treatment and Coinfection

edited by

Daniel Sepúlveda-Crespo

and

Salvador Resino

submission deadline 30 Nov 2024 | 4 articles | Viewed by 6442 | Submission Open

Keywords: coinfection; drug discovery; HBV; HCV; HDV; HIV; neutralizing antibodies; prevention; treatment; vaccine

(This special issue belongs to the Section Biopharmaceuticals)

Innovative Tools for Drug Analysis and Therapeutic Drug Monitoring (TDM)

edited by

Juraj Piestansky

and

Andrej Kovac

submission deadline 30 Nov 2024 | 4 articles | Viewed by 5106 | Submission Open

Keywords: therapeutic drug monitoring; analysis of drugs; separation analytical methods; mass spectrometry; bioanalysis; quality control; dosage forms; green analytical chemistry

(This special issue belongs to the Section Pharmacology)

HTLV-1: Molecular Insights to Targeted Elimination Strategies

edited by

Juliana Echevarria Neves de Lima

and

Goedele N. Maertens

submission deadline 30 Nov 2024 | 2 articles | Viewed by 4719 | Submission Open

Keywords: HTLV-1; adult T-cell leukemia/Lymphoma (ATLL); HTLV-1-associated myelopathic/tropical spastic paraparesis (HAM/TSP); treatment; new compounds; drug repositing and immunotherapy

(This special issue belongs to the Section Pharmacology)

Cardiovascular Diseases: Where Do We Stand with Human-Derived Stem Cells?

edited by

Daniela Malan

and

Giulia Querio

submission deadline 30 Nov 2024 | 2 articles | Viewed by 3070 | Submission Open

Keywords: hiPSC; regenerative medicine; personalized medicine; cardiovascular disease

(This special issue belongs to the Section Biopharmaceuticals)

Lipid-Nanoparticle-Mediated Delivery of Small-Molecule and Nucleic Acid-Based Therapeutics

edited by

Okhil Kumar Nag

submission deadline 30 Nov 2024 | 2 articles | Viewed by 2650 | Submission Open

(This special issue belongs to the Section Pharmaceutical Technology)

Bioactive Compounds From Plants and Their Therapeutic Applications in Lifestyle-Related Diseases

edited by

Syota Kagawa

and

Agnieszka Ludwiczuk

submission deadline 30 Nov 2024 | 2 articles | Viewed by 2614 | Submission Open

Keywords: natural compounds; lifestyle-related diseases; pharmacology; molecular mechanisms; clinical applications

(This special issue belongs to the Section Natural Products)

Antiviral Agents, 2024

edited by

Luis Octavio Regasini

submission deadline 30 Nov 2024 | 2 articles | Viewed by 2560 | Submission Open

Keywords: antiviral; virus; arbovirus; drugs; protease; helicase; polymerase; reverse transcriptase

(This special issue belongs to the Section Medicinal Chemistry)

Natural Products Derived from Fungi and Their Biological Activities

edited by

Katarzyna J. Kała

submission deadline 30 Nov 2024 | 1 articles | Viewed by 1860 | Submission Open

Keywords: fungi; medicinal fungi; fruiting bodies; mycelial cultures; bioactive compounds; pro-health activity; mushroom products; natural therapy; natural medicines

(This special issue belongs to the Section Natural Products)

Potential Therapeutic Methods in Reproductive Aging

edited by

Bosun Joo

submission deadline 30 Nov 2024 | 1 articles | Viewed by 1784 | Submission Open

Keywords: ovarian aging; menopause; infertility; ovarian longevity/rejuvernation; angiogenesis; antioxidant; stem cells; platelet-rich plasma

Medicinal Metal Ions and Metal-Based Complex

edited by Rosita Cappai and

Valeria M. Nurchi

submission deadline 30 Nov 2024 | 1 articles | Viewed by 1768 | Submission Open

Keywords: metal complexes; metal-based drugs; medicinal chemistry; chelating agents; solution equilibria

(This special issue belongs to the Section Medicinal Chemistry)

Discovery of Novel Antidepressants and Anxiolytics

edited by James Oluwagbamigbe Fajemiroye and Gunnar P. H. Dietz

submission deadline 30 Nov 2024 | 1 articles | Viewed by 1498 | Submission Open

Keywords: biomarkers; depression; anxiety; anxiolytics; antidepressants; preclinical or clinical overview; experimental data; adverse effects; pharmacotherapy options; novel drugs

(This special issue belongs to the Section Pharmacology)

Plant-Based Therapies for Circulatory Disorders

edited by

Priscila De Souza

submission deadline 30 Nov 2024 | 2 articles | Viewed by 1453 | Submission Open

Keywords: plant extracts; isolated compounds from medicinal plants; hypertension; dyslipidemia; atherosclerosis; myocardial infarction; cardiac ischemia; heart failure; stroke; kidney disease

Molecular Imaging of the Tumor Microenvironment

edited by

Hui-Yen Chuang

submission deadline 30 Nov 2024 | 1 articles | Viewed by 1132 | Submission Open

Keywords: molecular imaging; radiopharmaceuticals; tumor microenvironment; immune microenvironment; angiogenesis; pH sensors; theranostics; nanoparticles; drug delivery

(This special issue belongs to the Section Radiopharmaceutical Sciences)

Barrier Dynamics and Immune Interplay in Brain Aging and Injury

edited by

Hansen Chen

, Congcong Wang, Xin Wang and Zongshi Qin

submission deadline 30 Nov 2024 | Viewed by 726 | Submission Open

Keywords: aging; neurodegenerative and neurovascular disorders; blood– brain barrier; immune response; adjunct therapy

(This special issue belongs to the Section Pharmacology)

Drug Candidates for the Treatment of Pain (2024/2025)

edited by

Marco Fiore

submission deadline 30 Nov 2024 | Viewed by 329 | Submission Open

Keywords: pain; analgesia; drug discovery; drug candidates; new drugs

Targeting Opioid Receptors for Innovative Therapies: Present and Emerging Concepts in Opioid Cure

edited by

Piotr Poznanski

Marzena Łazarczyk

and

Dominik Skiba

submission deadline 30 Nov 2024 | Viewed by 278 | Submission Open

Keywords: opioid system; brain injury; pain; neurodegenerative diseases; addiction; cardiovascular diseases; cancer

(This special issue belongs to the Section Medicinal Chemistry)

Metal Chelating Agents in Medicinal Chemistry

edited by

Grigoris Zoidis

submission deadline 30 Nov 2024 | Viewed by 259 | Submission Open

Keywords: metal chelating agents; metalloenzymes; metalloenzyme inhibitors

(This special issue belongs to the Section Medicinal Chemistry)

Advances in Peptide Chemistry and Medicinal Application

edited by

Santo Previti

submission deadline 30 Nov 2024 | Viewed by 249 | Submission Open

Keywords: peptide-based compounds; peptidomimetics; drug discovery; drug-like properties; target modulation; structure– activity relationship studies; unnatural amino acids; backbone modifications; antibodies; hydrogels

(This special issue belongs to the Section Medicinal Chemistry)

Innovative Applications and Therapeutic Potential of Cannabinoids

edited by

Anna Stasiłowicz-Krzemień

and

Judyta Cielecka-Piontek

submission deadline 30 Nov 2024 | Viewed by 185 | Submission Open

Keywords: cannabis; cannabinoids; cannabidiol; tetrahydrocannabinol; endocannabinoid system; biopharmaceuticals; pharmacology; drug delivery

(This special issue belongs to the Section Medicinal Chemistry)

Theragnostic Agents Utilized in Magnetic Resonance Imaging (MRI) Advances as Novel Contrast Agents

edited by

Irena Pashkunova-Martic

and Cécile Philippe

submission deadline 30 Nov 2024 | Viewed by 150 | Submission Open

Keywords: cancer theranostics; MRI; high-relaxivity agents; gadolinium-free contrast agents; cancer-targeting ligands; specific MRI agents; drug-loading MRI agents; hyperthermal MRI agents; multifunctional MRI contrast agents

(This special issue belongs to the Section Pharmaceutical Technology)

The 20th Anniversary of Pharmaceuticals—How Artificial Intelligence Is Reshaping Pharmaceuticals Technology

edited by

Serge Mordon

submission deadline 1 Dec 2024 | 10 articles | Viewed by 14263 | Submission Open

Keywords: drug delivery; drug analysis; pharmaceutical technology; controlled release and sustained release; formula design; artificial intelligence

(This special issue belongs to the Section Pharmaceutical Technology)

Inhibition and Treatment in Adhesion, Migration, Invasion, and Metastasis of Cancer Cells

edited by