New Trends in Terahertz Photonics

A special issue of Photonics (ISSN 2304-6732). This special issue belongs to the section "Optical Interaction Science".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 415

Special Issue Editor


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Guest Editor
Terahertz Technology Innovation Research Institute, Shanghai Key Lab of Modern Optical System, Terahertz Science Cooperative Innovation Center University of Shanghai for Science and Technology Shanghai Institute of Intelligent Science and Technology, Shanghai 200093, China
Interests: terahertz technology; spectroscopy; metamaterials; biomedicine; nonlinear spectroscopy; optical devices; imaging; Rydberg state
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Special Issue Information

Dear Colleagues,

Terahertz photonics is a rapidly growing field with significant potential for biomedical detection. This Special Issue, “New Trends in Terahertz Photonics”, aims to highlight the latest advancements and innovative research in the terahertz domain. The scope of this Special Issue encompasses a broad range of topics, including but not limited to optical devices, electric field probes, imaging techniques, non-destructive testing, numerical simulations, metamaterials, biomedicine, spectral databases, nonlinear spectroscopy, and the Rydberg state.

Terahertz spectroscopy is mainly based on the unique terahertz properties of different biomolecules or different binding modes between biomolecules and analyzes the differences in absorption or reflection coefficients to identify the target substances. Terahertz spectroscopy studies cover different biological levels from cells to tissues. The rotational and vibrational energy levels of biomolecules (e.g., proteins, etc.) are mostly within the terahertz band, and different biomolecules have their own distinctive fingerprint spectra. Meanwhile, the photons of terahertz radiation have a low energy, a millionth of that of X-rays, therefore causing no damage to the biological samples. Thus, terahertz technology is highly suitable for spectroscopic and imaging studies of biological samples.

Terahertz technology, as a detection method, can be integrated with metamaterials, Rydberg atoms, near-field imaging, and other techniques to analyze biomedical samples. The integration of terahertz detection technology with metamaterials can enhance the electromagnetic field, thereby enabling molecular detection of higher sensitivity. Rydberg atoms exhibit exceptionally large electric dipole moments in the terahertz frequency bands. Quantum interference effects enable the detection of the electromagnetic field with higher sensitivity within this frequency range, with theoretical sensitivity surpassing that of current detection technologies. Near-field imaging technology can acquire images of biomedical samples at the microscopic level and provide spectral analysis. Additionally, we welcome submissions on other technologies associated with terahertz detection.

All types of contributions, i.e., research papers, reviews, and communications, are welcome.

Prof. Dr. Yan Peng
Guest Editor

Manuscript Submission Information

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Keywords

  • optical devices
  • electric field probe
  • imaging techniques
  • non-destructive testing
  • numerical simulations
  • metamaterials
  • biomedicine
  • spectral database
  • nonlinear spectroscopy
  • Rydberg state

Published Papers (1 paper)

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Research

9 pages, 7038 KiB  
Article
The Rapid Detection of Paclitaxel-Induced Changes in Cervical Cancer Cells Using an Ultrasensitive Biosensor
by Liwen Zhang, Gan Chen, Yating Hao and Yan Peng
Photonics 2024, 11(8), 735; https://doi.org/10.3390/photonics11080735 - 7 Aug 2024
Viewed by 262
Abstract
Background: Paclitaxel is a widely used cancer treatment drug that has a significant inhibitory effect on cervical cancer cells (HeLa cells). This study aims to investigate the effects of paclitaxel on HeLa cells and evaluate the application of terahertz (THz) spectroscopy and surface [...] Read more.
Background: Paclitaxel is a widely used cancer treatment drug that has a significant inhibitory effect on cervical cancer cells (HeLa cells). This study aims to investigate the effects of paclitaxel on HeLa cells and evaluate the application of terahertz (THz) spectroscopy and surface plasmon resonance (SPR) biosensors in this process. Methods: We utilized an SPR biosensor in conjunction with THz spectroscopy to measure the terahertz absorbance spectra of HeLa cells exposed to various concentrations of paclitaxel. The minimum number of cells used for detection was 15.25 × 105. At the same time, cell proliferation levels were assessed through proliferation assays and compared with the terahertz spectroscopy data. Results: The experimental results indicated that with the increasing concentration of paclitaxel, the terahertz absorbance spectra of HeLa cells exhibited a blue shift, and cell proliferation was significantly inhibited. The results of the proliferation assays were consistent with the terahertz spectroscopy data, validating the effectiveness of this method. Conclusion: This study demonstrates that the combination of THz spectroscopy and SPR biosensors is a promising technology that can provide a simple, rapid, and low-cost method for studying chemistry–biology relationships, especially in the field of drug evaluation. Full article
(This article belongs to the Special Issue New Trends in Terahertz Photonics)
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