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Photonics
Special Issues
Optical Elastography: Current Status and Future Applications
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Optical Elastography: Current Status and Future Applications

A special issue of Photonics (ISSN 2304-6732). This special issue belongs to the section "New Applications Enabled by Photonics Technologies and Systems".

Deadline for manuscript submissions: closed (30 April 2022) | Viewed by 5674

Special Issue Editor

Prof. Dr. Kirill Larin

E-Mail Website
Guest Editor
Department of Biomedical Engineering, University of Houston, Houston, TX 77204, USA
Interests: optical coherence tomography; microscopy; biomechanics; developmental biology

Special Issue Information

Dear Colleagues,

Optical elastography uses optics to characterize elastic and viscoelastic mechanical properties of tissues and cells. This rapidly emerging field builds on and complements related methods for biomechanics, such as atomic force microscopy, traction force microscopy and microrheology, and the fields of ultrasound and magnetic resonance elastography.

Mechanical forces play an important role in the behavior and development of biological systems and disease at all spatial scales, from cells and their constituents to tissues and organs. Such forces profoundly influence the health, structural integrity, and normal function of cells and organs. At the same time, accurate knowledge of tissue biomechanical properties is essential for the same reasons. Optical elastography and biomechanics methods will aid in the understanding and clinical diagnosis of a wide variety of diseases.

This Special Issue aims to collect papers on biomedical optics, biophotonics, and biomechanical methods and technologies applied or related to estimation, monitoring, and functional assessment of the mechanical properties of normal and pathological biomaterials at all spatial scales, from cells and their constituents to tissues and organs. Relevant topics include (but are not limited to):

  • Optical elastography methods in general;
  • Optical coherence tomography/elastography;
  • Brillouin spectroscopy;
  • Multimodal elastography;
  • Speckle and particle tracking, and holography;
  • Signal processing methods for optical elastography quantitative methods, including combining modeling and measurement;
  • Novel loading schemes.

Prof. Dr. Kirill Larin
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Photonics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Optical elastography applications in general
  • In vivo elastography
  • Elastography in cardiology
  • Ophthalmic applications of optical elastography
  • Optical elastography methods for eye biomechanics
  • Hard tissue biomechanics in bones and dental applications
  • Biomechanics in animal models
  • Biomechanics in tissue engineering
  • Biomechanics in developmental biology

Published Papers (3 papers)

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Research

10 pages, 1663 KiB  
Article
Preliminary Results of Noninvasive Ocular Rigidity in Diabetic Retinopathy Using Optical Coherence Tomography
by Yanhui Ma, Matthew P. Ohr and Cynthia J. Roberts
Photonics 2022, 9(9), 598; https://doi.org/10.3390/photonics9090598 - 24 Aug 2022
Cited by 1 | Viewed by 1568
Abstract
The pathologic mechanism of diabetic retinopathy is directly related to the underlying hyperglycemia associated with diabetes. Hyperglycemia causes non-enzymatic cross-linking of collagen fibrils which contributes mechanistically to tissue stiffening. However, investigations on diabetic retinopathy-associated alteration in ocular biomechanics remain scarce, especially in living [...] Read more.
The pathologic mechanism of diabetic retinopathy is directly related to the underlying hyperglycemia associated with diabetes. Hyperglycemia causes non-enzymatic cross-linking of collagen fibrils which contributes mechanistically to tissue stiffening. However, investigations on diabetic retinopathy-associated alteration in ocular biomechanics remain scarce, especially in living human eyes. Ocular rigidity is classically defined as a measure of the change in intraocular pressure produced by a change in ocular volume. We recently implemented an approach for the direct in-vivo non-invasive estimate of ocular rigidity using optical coherence tomography, allowing for the evaluation of the biomechanical behavior in eyes with diabetic retinopathy. Our preliminary results showed that diabetic retinopathy exhibited higher ocular rigidity and higher scleral stiffness compared to normal controls, which may possibly be attributed to hyperglycemia-induced collagen cross-linking in the ocular tissues. Knowledge of diabetic retinopathy-associated biomechanical changes will equip us with new quantitative tools to identify diagnostic markers in diabetic retinopathy. Full article
(This article belongs to the Special Issue Optical Elastography: Current Status and Future Applications)
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16 pages, 4976 KiB  
Article
Image Quality Assessment for Digital Volume Correlation-Based Optical Coherence Elastography
by Xianglong Lin, Jinlong Chen, Yongzheng Hu, Xiaowei Feng, Haosen Wang, Haofei Liu and Cuiru Sun
Photonics 2022, 9(8), 573; https://doi.org/10.3390/photonics9080573 - 15 Aug 2022
Cited by 2 | Viewed by 1816
Abstract
Optical coherence elastography (OCE) based on digital volume correlation (DVC) has the advantages of full 3D displacements and strain tensor quantification. However, the measurement results are often unreliable due to the poor quality of the optical coherence tomography (OCT) speckle patterns. This paper [...] Read more.
Optical coherence elastography (OCE) based on digital volume correlation (DVC) has the advantages of full 3D displacements and strain tensor quantification. However, the measurement results are often unreliable due to the poor quality of the optical coherence tomography (OCT) speckle patterns. This paper proposes an image evaluation index based on OCT-DVC (CMGG, combined mean attenuation intensity, breadth and dispersion of the gray level distribution), which comprehensively considers the OCT signals’ attenuation and the breadth and dispersion of the gray level distribution of the OCT images. Virtual deformation experiments of phantoms by numerically applied displacements and deformation measurement of pork meat were conducted. The results of the mean bias errors have a corresponding good relationship with CMGG, which demonstrates the effectiveness of the proposed CMGG. Based on this index, a lot of time may be saved by a pretest evaluation during DVC-OCE measurement. CMGG also guides the development of OCE system design, adjustment and new DVC-OCE algorithms. Full article
(This article belongs to the Special Issue Optical Elastography: Current Status and Future Applications)
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15 pages, 3900 KiB  
Article
Novel Elastography-Inspired Approach to Angiographic Visualization in Optical Coherence Tomography
by Alexey A. Zykov, Alexander L. Matveyev, Lev A. Matveev, Dmitry V. Shabanov and Vladimir Y. Zaitsev
Photonics 2022, 9(6), 401; https://doi.org/10.3390/photonics9060401 - 7 Jun 2022
Cited by 1 | Viewed by 1689
Abstract
In this paper, we present a new approach to contrast-agent-free angiographic visualization in optical coherence tomography (OCT). The proposed approach has much in common with imaging of local interframe strains in OCT-based elastography and utilizes the fact that the interframe motion of blood [...] Read more.
In this paper, we present a new approach to contrast-agent-free angiographic visualization in optical coherence tomography (OCT). The proposed approach has much in common with imaging of local interframe strains in OCT-based elastography and utilizes the fact that the interframe motion of blood particles leads to discontinuity of strains within the vessel cross section. By this reasoning, we call this approach “elastography-inspired”. Here, we first elucidate the essence and main features of the elastography-inspired approach using numerical simulation of OCT data. The simulations allow one to introduce both moving scatterers imitating blood flow in vessels as well as various masking motions imitating natural motions of living “solid” tissue surrounding the vessels. Second, using real OCT signals, we present comparative results of angiographic processing using the proposed elastography-inspired approach and a realization of OCA based on high-pass filtering of temporal variability of a series of OCT B-scans. The two methods can use the same initial dataset and the high-pass filtering OCA has already been routinely applied in both animal experiments and on patients. The new elastography-inspired method has a similar computational efficiency, and it is intrinsically able to compensate spatially-inhomogeneous masking tissue motions and demonstrates high robustness with respect to motion artefacts. Thus, the new approach looks very promising for enabling wider application of OCA in both laboratory studies on animals and, most importantly, for wider clinical applications on patients. Full article
(This article belongs to the Special Issue Optical Elastography: Current Status and Future Applications)
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