Biomedical Photonics Advances

Dear Colleagues,

As an efficient imaging and diagnostic tool, the salient properties of light, including the frequency, coherence, complex wave fronts, orbital and spin angular momentum and polarization, have had  high impacts in the fields of life science and medicine. In particular, how light is absorbed, scattered and emitted in tissues can reveal tissues’ healthy or diseased status. For example, cancer tissue emits and scatters light in a different way compared to normal healthy tissue. Recently we discovered four optical windows, at NIR (650 nm to 950 nm) and short wavelength radiation (1100 nm to 1350 nm), (1600 nm to 1870 nm), and (2100 nm to 2300 nm), which display great potential for deep tissue imaging and low-light-level therapy, such as wound healing.

Combing different types of laser sources, such as supercontinuum, laser diodes, and LED that span the NIR and SWIR ranges with photodetector beyond the silicon limit of 1000 nm, such as InGaAs, InSb and others from 900 to 2500 nm detection range, the state-of-art cutting edge advances in light offer a panoply of imaging techniques for deeper tissue imaging with linear and nonlinear optical methods. Selective wavelengths or molecules for resonance effects from electronic states and vibrational states offer significant reduction of the acquisition time to seconds and significant enhancement of Raman signals 100 to 1000 fold; an example is using a 532 nm light as the excitation source for Resonance Raman from molecule vibrations in biological tissues. In addition, studies of light pulse propagation in brain tissue with classical (radial polarized) and quantum (twin) entangled photons theories inspire the study of quasi particles in brain and other tissues.

Papers submitted to this Special Issue will cover, but are not limit to, topics related to the above, as well as topics listed below:

• non- or minimum-invasive spectroscopy for brain function, neuro degeneration, neuro pathologies and cancer
• non- or minimum-invasive functional spectroscopy for muscles and bones
• non-invasive spectroscopy for breast and cervix cancer and pathologies
• SRS imaging of brain and other tissues
• RR imaging of skin, cervix, breast and arteries
• photobiomodulation for wound healing and brain disorders
• coherent imaging, such as OCT for various medical applications
• spatial frequency to study structural changes in tissues
• high resolution microscopy method to image toward the nm scale
• ultraviolet advances in microscopy for pathology, and probing inside cell world for DNA and microtubules
• quantum effects in brain
• light propagation and transmission in brain neuron tree maze
• classical and quantum entangled photons
• classical and quantum entanglement in tissues and cell
• quasi particles in tissue and brains

Prof. Robert R. Alfano
Dr. Lingyan Shi
Guest Editors

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