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Polymers
Special Issues
Advanced Polymers in Tissue Engineering and Drug Delivery
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Advanced Polymers in Tissue Engineering and Drug Delivery

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: closed (25 January 2024) | Viewed by 4478

Special Issue Editors

Dr. Xiangchao Pang

E-Mail Website
Guest Editor
College of Materials Science and Engineering, Central South University of Forestry and Technology, Changsha 41004, China
Interests: advanced polymer; tissue engineering; biomaterials; polymeric nanoparticles; biodegradable polymers; hydrogels; biocompatibility; polymeric implants; polymer networks; polymer coatings; nanofibers
Prof. Dr. Bin Tang

E-Mail Website
Guest Editor
Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen 518055, China
Interests: biomaterials; hydrogels; scaffolds; biocompatibility; tissue regeneration; targeted delivery; polymeric implants; polymer networks; polymer coatings; nanofibers; mechanical properties

Special Issue Information

Dear Colleagues,

The field of tissue engineering and drug delivery has been significantly advanced by the use of polymers. Advanced polymers are used to create biocompatible and biodegradable materials that can mimic the natural extracellular matrix of tissues, promoting cell growth and regeneration. These polymers can also be used to encapsulate drugs, allowing for targeted and sustained drug delivery.

In tissue engineering, polymers can be used to create scaffolds that provide structural support for the growth of cells and tissues. These scaffolds can be designed to mimic the mechanical properties of natural tissues, ensuring optimal growth and integration with surrounding tissues. In drug delivery, polymers can be used to encapsulate drugs and release them in a controlled manner. This allows for targeted delivery to specific tissues or cells, reducing the risk of side effects and increasing therapeutic efficacy.

Advanced polymers also have the potential to revolutionize the field of regenerative medicine by allowing for the creation of complex tissues and organs. While there are still challenges to overcome, such as improving the mechanical properties of polymers and ensuring long-term biocompatibility, the use of advanced polymers in tissue engineering and drug delivery holds great promise for the future of medicine.

Dr. Xiangchao Pang
Prof. Dr. Bin Tang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • advanced polymer
  • tissue engineering
  • drug delivery
  • biomaterials
  • polymeric nanoparticles
  • biodegradable polymers
  • hydrogels
  • nanocomposites
  • scaffolds
  • polymer conjugates
  • controlled release
  • biocompatibility
  • regenerative medicine
  • cell signaling
  • tissue regeneration
  • polymeric micelles
  • drug encapsulation
  • targeted delivery
  • polymeric implants
  • polymer networks
  • polymer blends
  • polymer coatings
  • nanofibers

Published Papers (3 papers)

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Research

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18 pages, 17023 KiB  
Article
Gelatin-Functionalized Carbon Nanotubes Loaded with Cisplatin for Anti-Cancer Therapy
by Rong Li, Zhenfei Bao, Pei Wang, Yunyun Deng, Junping Fan, Xin Zhu, Xinyu Xia, Yiming Song, Haiyan Yao and Dongfang Li
Polymers 2023, 15(16), 3333; https://doi.org/10.3390/polym15163333 - 8 Aug 2023
Cited by 4 | Viewed by 1547
Abstract
Cisplatin (Cp), a chemotherapeutic agent, interacts with purines on tumor DNA, causing tumor cell apoptosis. However, cisplatin has the characteristics of non-specific distribution and lack of selectivity, resulting in systemic toxicity. Moreover, it cannot maintain the drug’s high concentration in the tumor-weak acid [...] Read more.
Cisplatin (Cp), a chemotherapeutic agent, interacts with purines on tumor DNA, causing tumor cell apoptosis. However, cisplatin has the characteristics of non-specific distribution and lack of selectivity, resulting in systemic toxicity. Moreover, it cannot maintain the drug’s high concentration in the tumor-weak acid environment. These flaws of cisplatin restrict its use in clinical applications. Therefore, a pH-responsive carbon nanotube-modified nano-drug delivery system (CNTs/Gel/Cp) was constructed in this study using gelatin (Gel)-modified carbon nanotubes (CNTs/Gel) loaded with cisplatin to release drugs precisely and slowly, preventing premature inactivation and maintaining an effective concentration. When MCp:MCNTs/Gel = 1:1, the drug reaches the highest loading rate and entrapment efficiency. To achieve the sustained-release effect, CNTs/Gel/Cp can release the medicine steadily for a long time in a pH environment of 6.0. Additionally, CNTs/Gel/Cp display antitumor properties comparable to cisplatin in a manner that varies with the dosage administered. These findings indicate that CNTs/Gel/Cp have an effective, sustained release of cisplatin and a good antitumor effect, providing a theoretical and experimental basis for the clinical application of modified carbon nanotubes (CNTs) as a new drug delivery system. Full article
(This article belongs to the Special Issue Advanced Polymers in Tissue Engineering and Drug Delivery)
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11 pages, 2952 KiB  
Article
Controlled Release and Cell Viability of Ketoconazole Incorporated in PEG 4000 Derivatives
by Carolina R. Inácio, Gabriel S. Nascimento, Ana Paula M. Barboza, Bernardo R. A. Neves, Ângela Leão Andrade, Gabriel M. Teixeira, Lucas R. D. Sousa, Paula M. de A. Vieira, Kátia M. Novack and Viviane M. R. dos Santos
Polymers 2023, 15(11), 2513; https://doi.org/10.3390/polym15112513 - 30 May 2023
Cited by 1 | Viewed by 1029
Abstract
In recent years, polymeric materials have been gaining prominence in studies of controlled release systems to obtain improvements in drug administration. These systems present several advantages compared with conventional release systems, such as constant maintenance in the blood concentration of a given drug, [...] Read more.
In recent years, polymeric materials have been gaining prominence in studies of controlled release systems to obtain improvements in drug administration. These systems present several advantages compared with conventional release systems, such as constant maintenance in the blood concentration of a given drug, greater bioavailability, reduction of adverse effects, and fewer dosages required, thus providing a higher patient compliance to treatment. Given the above, the present work aimed to synthesize polymeric matrices derived from polyethylene glycol (PEG) capable of promoting the controlled release of the drug ketoconazole in order to minimize its adverse effects. PEG 4000 is a widely used polymer due to its excellent properties such as hydrophilicity, biocompatibility, and non-toxic effects. In this work, PEG 4000 and derivatives were incorporated with ketoconazole. The morphology of polymeric films was observed by AFM and showed changes on the film organization after drug incorporation. In SEM, it was possible to notice spheres that formed in some incorporated polymers. The zeta potential of PEG 4000 and its derivatives was determined and suggested that the microparticle surfaces showed a low electrostatic charge. Regarding the controlled release, all the incorporated polymers obtained a controlled release profile at pH 7.3. The release kinetics of ketoconazole in the samples of PEG 4000 and its derivatives followed first order for PEG 4000 HYDR INCORP and Higuchi for the other samples. Cytotoxicity was determined and PEG 4000 and its derivatives were not cytotoxic. Full article
(This article belongs to the Special Issue Advanced Polymers in Tissue Engineering and Drug Delivery)
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Review

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23 pages, 6350 KiB  
Review
Current Advances in the Use of Tissue Engineering for Cancer Metastasis Therapeutics
by Preeya D. Katti and Haneesh Jasuja
Polymers 2024, 16(5), 617; https://doi.org/10.3390/polym16050617 - 23 Feb 2024
Cited by 1 | Viewed by 1264
Abstract
Cancer is a leading cause of death worldwide and results in nearly 10 million deaths each year. The global economic burden of cancer from 2020 to 2050 is estimated to be USD 25.2 trillion. The spread of cancer to distant organs through metastasis [...] Read more.
Cancer is a leading cause of death worldwide and results in nearly 10 million deaths each year. The global economic burden of cancer from 2020 to 2050 is estimated to be USD 25.2 trillion. The spread of cancer to distant organs through metastasis is the leading cause of death due to cancer. However, as of today, there is no cure for metastasis. Tissue engineering is a promising field for regenerative medicine that is likely to be able to provide rehabilitation procedures to patients who have undergone surgeries, such as mastectomy and other reconstructive procedures. Another important use of tissue engineering has emerged recently that involves the development of realistic and robust in vitro models of cancer metastasis, to aid in drug discovery and new metastasis therapeutics, as well as evaluate cancer biology at metastasis. This review covers the current studies in developing tissue-engineered metastasis structures. This article reports recent developments in in vitro models for breast, prostate, colon, and pancreatic cancer. The review also identifies challenges and opportunities in the use of tissue engineering toward new, clinically relevant therapies that aim to reduce the cancer burden. Full article
(This article belongs to the Special Issue Advanced Polymers in Tissue Engineering and Drug Delivery)
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