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Polymers
Special Issues
Advanced Polymer-Based Biomaterials
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Advanced Polymer-Based Biomaterials

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biomacromolecules, Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: closed (31 January 2022) | Viewed by 13536

Special Issue Editors

Prof. Dr. Tatiana A. Akopova

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Guest Editor
Enikolopov Institute of Synthetic Polymeric Materials, Russian Academy of Sciences (ISPM RAS), 70 Profsoyuznaya st., 117393 Moscow, Russia
Interests: polymer chemistry; supramolecular structure; polysaccharides; graft-copolymers; hybrid composites; biomaterials; solvent-free extrusion
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Christian Grandfils

E-Mail Website
Guest Editor
CEIB-Interfaculty Research Centre of Biomaterials, University of Liège, B-4000 Liège, Belgium
Interests: polymers; synthesis; scaffolds; nanoparticles; aliphatic polyesters; drug delivery; hydrogels
Dr. Tatiana S. Demina

E-Mail Website
Guest Editor
Enikolopov Institute of Synthetic Polymeric Materials, Russian Academy of Sciences (ISPM RAS), 70 Profsoyuznaya st., 117393 Moscow, Russia
Interests: materials; tissue engineering; polysaccharides; biopolymers; scaffolds; surface modification; delivery systems; mechanochemistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The crucial importance of polymers in most medical activities cannot be underestimated today. Polymer materials are indeed widely used either as non-biodegradable medical devices (stents, shunts, ligaments, etc.), or as biodegradable multifunctional scaffolds for tissue engineering. Even if synthetic polymers accepted for biomedical application are safe, their properties nevertheless remain completely different compared to those of natural macromolecules typically found in our extracellular matrix. Accordingly, polymer biomaterials suffer from several drawbacks when implanted within our body, among them a lack of biointegration, inadequacy in mechanical properties or limited diffusion properties. The challenges of macromolecular engineering in developing a new generation of polymer-based materials are multiple and should cover modification of their chemical structure, the fabrication of polymer hybrid composites, as well as their post-treatment for surface functionalization. These challenges can only be solved if more efforts are spent to promote the integration of at least the following disciplines: medical activity, physics and chemistry of materials, cell biology, and material engineering.

Prof. Dr. Tatiana A. Akopova
Prof. Dr. Christian Grandfils
Dr. Tatiana S. Demina
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biocompatible polymers
  • bioactive substances
  • tissue engineering
  • scaffolds
  • biodegradation
  • cell attachment
  • cell proliferation
  • drug targeting

Published Papers (4 papers)

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Research

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19 pages, 27744 KiB  
Article
Fabrication of Antheraea pernyi Silk Fibroin-Based Thermoresponsive Hydrogel Nanofibers for Colon Cancer Cell Culture
by Bo-Xiang Wang, Jia Li, De-Hong Cheng, Yan-Hua Lu and Li Liu
Polymers 2022, 14(1), 108; https://doi.org/10.3390/polym14010108 - 29 Dec 2021
Cited by 4 | Viewed by 2180
Abstract
Antheraea pernyi silk fibroin (ASF)-based nanofibers have wide potential for biomaterial applications due to superior biocompatibility. It is not clear whether the ASF-based nanofibers scaffold can be used as an in vitro cancer cell culture platform. In the current study, we fabricated novel [...] Read more.
Antheraea pernyi silk fibroin (ASF)-based nanofibers have wide potential for biomaterial applications due to superior biocompatibility. It is not clear whether the ASF-based nanofibers scaffold can be used as an in vitro cancer cell culture platform. In the current study, we fabricated novel ASF-based thermoresponsive hydrogel nanofibers by aqueous electrospinning for colon cancer (LoVo) cells culture. ASF was reacted with allyl glycidyl ether (AGE) for the preparation of allyl silk fibroin (ASF-AGE), which provided the possibility of copolymerization with allyl monomer. The investigation of ASF-AGE structure by 1H NMR revealed that reactive allyl groups were successfully linked with ASF. ASF-based thermoresponsive hydrogel nanofibers (p (ASF-AGE-NIPAAm)) were successfully manufactured by aqueous electrospinning with the polymerization of ASF and N-isopropylacrylamide (NIPAAm). The p (ASF-AGE-NIPAAm) spinning solution showed good spinnability with the increase of polymerization time, and uniform nanofibers were formed at the polymerization time of 360 min. The obtained hydrogel nanofibers exhibited good thermoresponsive that the LCST was similar with PNIPAAm at about 32 °C, and good degradability in protease XIV PBS solution. In addition, the cytocompatibility of colon cancer (LoVo) cells cultured in hydrogel nanofibers was assessed. It was demonstrated that LoVo cells grown on hydrogel nanofibers showed improved cell adhesion, proliferation, and viability than those on hydrogel. The results suggest that the p (ASF-AGE-NIPAAm) hydrogel nanofibers have potential application in LoVo cells culture in vitro. This study demonstrates the feasibility of fabricating ASF-based nanofibers to culture LoVo cancer cells that can potentially be used as an in vitro cancer cell culture platform. Full article
(This article belongs to the Special Issue Advanced Polymer-Based Biomaterials)
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13 pages, 3002 KiB  
Article
Layer-by-Layer Encapsulation of Herbicide-Degrading Bacteria for Improved Surface Properties and Compatibility in Soils
by Reut Gal, Neriya Perez-Lapid, Yael Zvulunov and Adi Radian
Polymers 2021, 13(21), 3814; https://doi.org/10.3390/polym13213814 - 4 Nov 2021
Viewed by 2246
Abstract
E. coli cells overexpressing the enzyme atrazine chlorohydrolase were coated using layer-by-layer self-assembly. The polymeric coating was designed to improve the surface properties of the cells and create positively charged, ecologically safe, bio-hybrid capsules that can efficiently degrade the herbicide atrazine in soils. [...] Read more.
E. coli cells overexpressing the enzyme atrazine chlorohydrolase were coated using layer-by-layer self-assembly. The polymeric coating was designed to improve the surface properties of the cells and create positively charged, ecologically safe, bio-hybrid capsules that can efficiently degrade the herbicide atrazine in soils. The physio-chemical properties of the bacteria/polymer interface were studied as a function of the polymeric composition of the shell and its thickness. Characterization of cell viability, enzyme activity, morphology, and size of the bio-capsules was done using fluorescence spectroscopy, BET and zeta potential measurements and electron microscopy imaging. Out of several polyelectrolytes, the combination of polydiallyldimethylammonium chloride and polysodium 4-styrenesulfonate improved the surface properties and activity of the cells to the greatest extent. The resulting bio-hybrid capsules were stable, well-dispersed, with a net positive charge and a large surface area compared to the uncoated bacteria. These non-viable, bio-hybrid capsules also exhibited a kinetic advantage in comparison with uncoated cells. When added to soils, they exhibited continuous activity over a six-week period and atrazine concentrations declined by 84%. Thus, the concept of layer-by-layer coated bacteria is a promising avenue for the design of new and sustainable bioremediation and biocatalytic platforms. Full article
(This article belongs to the Special Issue Advanced Polymer-Based Biomaterials)
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9 pages, 1074 KiB  
Article
The Effect of Stereocomplex Polylactide Particles on the Stereocomplexation of High Molecular Weight Polylactide Blends
by Muhammad Samsuri, Ihsan Iswaldi and Purba Purnama
Polymers 2021, 13(12), 2018; https://doi.org/10.3390/polym13122018 - 21 Jun 2021
Cited by 6 | Viewed by 2129
Abstract
Stereocomplexation is one of several approaches for improving polylactide (PLA) properties. The high molecular weight of poly L-lactide (PLLA) and poly D-lactide (PDLA) homopolymers are a constraint during the formation of stereocomplex PLAs (s-PLAs). The presence of s-PLA particles in PLA PLLA/PDLA blends [...] Read more.
Stereocomplexation is one of several approaches for improving polylactide (PLA) properties. The high molecular weight of poly L-lactide (PLLA) and poly D-lactide (PDLA) homopolymers are a constraint during the formation of stereocomplex PLAs (s-PLAs). The presence of s-PLA particles in PLA PLLA/PDLA blends can initiate the formation of s-PLA crystalline structures. We used the solution casting method to study the utilization of s-PLA materials from high molecular weight PLLA/PDLA blends for increasing s-PLA formation. The s-PLA particles initiated the formation of high molecular weight PLLA/PDLA blends, obtaining 49.13% s-PLA and 44.34% of the total crystalline fraction. In addition, the mechanical properties were enhanced through s-PLA crystalline formation and the increasing of total crystallinity of the PLLA/PDLA blends. The s-PLA particles supported initiation for s-PLA formation and acted as a nucleating agent for PLA homopolymers. These unique characteristics of s-PLA particles show potential to overcome the molecular weight limitation for stereocomplexation of PLLA/PDLA blends. Full article
(This article belongs to the Special Issue Advanced Polymer-Based Biomaterials)
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Review

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26 pages, 2511 KiB  
Review
Biodegradable Microparticles for Regenerative Medicine: A State of the Art and Trends to Clinical Application
by Anastasia A. Sherstneva, Tatiana S. Demina, Ana P. F. Monteiro, Tatiana A. Akopova, Christian Grandfils and Ange B. Ilangala
Polymers 2022, 14(7), 1314; https://doi.org/10.3390/polym14071314 (registering DOI) - 24 Mar 2022
Cited by 11 | Viewed by 5808
Abstract
Tissue engineering and cell therapy are very attractive in terms of potential applications but remain quite challenging regarding the clinical aspects. Amongst the different strategies proposed to facilitate their implementation in clinical practices, biodegradable microparticles have shown promising outcomes with several advantages and [...] Read more.
Tissue engineering and cell therapy are very attractive in terms of potential applications but remain quite challenging regarding the clinical aspects. Amongst the different strategies proposed to facilitate their implementation in clinical practices, biodegradable microparticles have shown promising outcomes with several advantages and potentialities. This critical review aims to establish a survey of the most relevant materials and processing techniques to prepare these micro vehicles. Special attention will be paid to their main potential applications, considering the regulatory constraints and the relative easiness to implement their production at an industrial level to better evaluate their application in clinical practices. Full article
(This article belongs to the Special Issue Advanced Polymer-Based Biomaterials)
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