Carbohydrate Polymers as Sustainable and Green Materials: Biosynthesis, Functionalization, and Emerging Applications

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Chemistry".

Deadline for manuscript submissions: closed (25 October 2023) | Viewed by 2414

Special Issue Editor


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Guest Editor
1. NanoStruc Research Group, Chemistry Department, Faculty of Science, Helwan University, Cairo 11795, Egypt
2. School of Chemical Sciences, Dublin City University, Dublin 9, D09 Y074 Dublin, Ireland
Interests: biomedicine; tissue engineering; biosensing; bioassays; drug delivery and environmental remediation

Special Issue Information

Dear Colleagues,

Carbohydrate polymers, such as sugar, starch, cellulose, hemicellulose and chitosan, are the most abundant biomolecules on our planet. Recently, carbohydrate polymers have been used in various biological and environmental applications due to their strong tendency to form supramolecular networks such as nanoparticles, hydrogels or aerogels, thin films and membranes, allowing for their application in drug delivery, bioimaging, biosensing and tissue engineering, with scientists over time modifying their functionalities to suit many other biomedical applications.

In this Special Issue, we aim to highlight the novel designs (particles, gels, foams, films and membranes) and diverse applications of carbohydrate-polymer-based systems in drug delivery, tissue engineering, medical diagnostics and therapy, biosensors, catalysis, energy materials, etc. We encourage the submission of contributions (original research articles as well as reviews) dealing with novel designs and novel applications of carbohydrate polymers.

Dr. Ahmed Barhoum
Guest Editor

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Published Papers (1 paper)

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Research

14 pages, 5933 KiB  
Article
Assessing the Antitumor Potential of Variants of the Extracellular Carbohydrate Polymer from Synechocystis ΔsigF Mutant
by Rita Mota, Raquel T. Lima, Carlos Flores, Juliana F. Silva, Beatriz Cruz, Bárbara Alves, Marta T. Pinto, Alessandra Adessi, Sara B. Pereira, Roberto De Philippis, Paula Soares and Paula Tamagnini
Polymers 2023, 15(6), 1382; https://doi.org/10.3390/polym15061382 - 10 Mar 2023
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Abstract
Cancer is a leading cause of death worldwide with a huge societal and economic impact. Clinically effective and less expensive anticancer agents derived from natural sources can help to overcome limitations and negative side effects of chemotherapy and radiotherapy. Previously, we showed that [...] Read more.
Cancer is a leading cause of death worldwide with a huge societal and economic impact. Clinically effective and less expensive anticancer agents derived from natural sources can help to overcome limitations and negative side effects of chemotherapy and radiotherapy. Previously, we showed that the extracellular carbohydrate polymer of a Synechocystis ΔsigF overproducing mutant displayed a strong antitumor activity towards several human tumor cell lines, by inducing high levels of apoptosis through p53 and caspase-3 activation. Here, the ΔsigF polymer was manipulated to obtain variants that were tested in a human melanoma (Mewo) cell line. Our results demonstrated that high molecular mass fractions were important for the polymer bioactivity, and that the reduction of the peptide content generated a variant with enhanced in vitro antitumor activity. This variant, and the original ΔsigF polymer, were further tested in vivo using the chick chorioallantoic membrane (CAM) assay. Both polymers significantly decreased xenografted CAM tumor growth and affected tumor morphology, by promoting less compact tumors, validating their antitumor potential in vivo. This work contributes with strategies for the design and testing tailored cyanobacterial extracellular polymers and further strengths the relevance of evaluating this type of polymers for biotechnological/biomedical applications. Full article
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