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Polymers
Special Issues
Advanced Hydrogels for Biomedical Application
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Advanced Hydrogels for Biomedical Application

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 1680

Special Issue Editors

Dr. Iksung Cho

E-Mail Website
Guest Editor
Institute for Materials Chemistry and Engineering (IMCE), Kyushu University, Fukuoka, Japan
Interests: polymeric biomaterial; hydrogel; stimuli-responsive; self-healing material; single-cell encapsulation; cell mechanotransduction
Dr. Tooru Ooya

E-Mail Website
Co-Guest Editor
1. Department of Chemical Science and Engineering, Graduate School of Engineering, Kobe University, Kobe, Japan
2. Center for Advanced Medical Engineering Research & Development (CAMED), Kobe University, Kobe, Japan
Interests: biofunctional materials; drug delivery systems; regenerative medical engineering materials; food materials; dendrimers; cyclodextrins

Special Issue Information

Dear Colleagues,

Hydrogels have experienced remarkable advances in biomedical applications, owing to their unique properties that mimic human tissue characteristics. These three-dimensional, water-swollen networks exhibit high biocompatibility and tuneable mechanical properties, making them ideal candidates for drug delivery systems, wound-healing scaffolds, and tissue engineering platforms. Recent innovations encompass the development of stimuli-responsive hydrogels, capable of controlled drug release in response to specific cues, such as pH or temperature changes. Furthermore, the integration of hydrogels with bioactive molecules and cells has enabled the creation of sophisticated constructs for regenerative medicine, providing a promising avenue to address a wide array of medical challenges.

Dr. Iksung Cho
Dr. Tooru Ooya
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hydrogel
  • polymeric biomaterial
  • stimuli-responsive
  • tissue engineering
  • drug delivery system

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Published Papers (2 papers)

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Research

13 pages, 2751 KiB  
Article
Enhancing Wound Recovery: A Self-Gelling Powder for Improved Hemostasis and Healing
by Yuzhou Zhao, Yanni Gao, Zihao Shen, Mingze Ni, Juan Xu and Ting Wang
Polymers 2024, 16(13), 1795; https://doi.org/10.3390/polym16131795 - 25 Jun 2024
Viewed by 810
Abstract
A novel self-gelatinizing powder was designed to accelerate wound healing through enhanced hemostasis and tissue recovery. Significantly, this research addresses the critical need for innovative wound management solutions by presenting a novel approach. Carboxymethylcellulose calcium (CMC-Ca) was synthesized using an ion exchange method, [...] Read more.
A novel self-gelatinizing powder was designed to accelerate wound healing through enhanced hemostasis and tissue recovery. Significantly, this research addresses the critical need for innovative wound management solutions by presenting a novel approach. Carboxymethylcellulose calcium (CMC-Ca) was synthesized using an ion exchange method, and lysine (Lys) was integrated through physical mixing to augment the material’s functional characteristics. The prepared powder underwent comprehensive evaluation for its self-gelling capacity, gelation time, adhesion, swelling rate, coagulation efficiency, hemostatic effectiveness, and wound healing promotion. Results indicate that the self-gelatinizing powder exhibited remarkable water absorption capabilities, absorbing liquid up to 30 times its weight and achieving rapid coagulation within 3 min. The inclusion of Lys notably enhanced the powder’s gel-forming properties. The gelation time was determined to be within 4 s using a rotational rheometer, with the powder rapidly forming a stable gel on the skin surface. Furthermore, in a mouse skin injury model, near-complete skin recovery was observed within 14 days, underscoring the powder’s impressive self-healing attributes and promising application prospects in wound management. Full article
(This article belongs to the Special Issue Advanced Hydrogels for Biomedical Application)
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17 pages, 5325 KiB  
Article
The Potential of Sugarcane Waste-Derived Cellulose Fibres as Haemostatic Agents
by Siobhan Malone, Ramanathan Yegappan, Amanda W. Kijas, Anna Gemmell, Alan E. Rowan, Divya Rajah, Minjun Kim, Jan Lauko and Nasim Amiralian
Polymers 2024, 16(12), 1654; https://doi.org/10.3390/polym16121654 - 11 Jun 2024
Viewed by 509
Abstract
Haemorrhage control during surgery and following traumatic injury remains a critical, life-saving challenge. Cellulose products are already employed in commercially available haemostatic dressings. This work explores sourcing cellulose from sugarcane trash pulp to produce micro- and nanosized fibres with hydroxyl, carboxylic acid, and [...] Read more.
Haemorrhage control during surgery and following traumatic injury remains a critical, life-saving challenge. Cellulose products are already employed in commercially available haemostatic dressings. This work explores sourcing cellulose from sugarcane trash pulp to produce micro- and nanosized fibres with hydroxyl, carboxylic acid, and trimethylamine functional groups, resulting in either positive or negative surface charges. This paper assesses the influence of these fibres on multiple blood clotting parameters in both dispersed solutions and dry gauze applications. In vitro blood clotting studies demonstrated the significant haemostatic potential of cellulose fibres derived from sugarcane waste to initiate clotting. Plasma absorbance assays showed that the 0.25 mg/mL cellulose microfibre dispersion had the highest clotting performance. It was observed that no single property of surface charge, functionality, or fibre morphology exclusively controlled the clotting initiation measured. Instead, a combination of these factors affected clot formation, with negatively charged cellulose microfibres comprising hydroxyl surface groups providing the most promising result, accelerating the coagulation cascade mechanism by 67% compared to the endogenous activity. This difference in clot initiation shows the potential for the non-wood agricultural waste source of cellulose in haemostatic wound healing applications, contributing to the broader understanding of cellulose-based materials’ versatility and their applications in biomedicine. Full article
(This article belongs to the Special Issue Advanced Hydrogels for Biomedical Application)
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