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Polymers for Drug Delivery and Wound Healing

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: closed (31 July 2021) | Viewed by 3719

Special Issue Editors


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Guest Editor
1. School of Pharmacy, Faculty of Medical Sciences, Newcastle University, London NE1 7RU, UK
2. Translational and Clinical Research Institute, Newcastle University, London NE1 7RU, UK
Interests: wound healing; drug delivery; drug formulation; skin; transdermal and topical delivery; polymers; mucous membranes; microbial biofilms; drug targeting, toxicology; drug design

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Co-Guest Editor
1. School of Pharmacy, Faculty of Medical Sciences, Newcastle University, London NE1 7RU, UK
2. Translational and Clinical Research Institute, Newcastle University, London NE1 7RU, UK
Interests: microneedles; nanotechnology; drug formulation; targeted drug delivery systems; accessible diagnostic technologies; disease detection; skin

Special Issue Information

Dear Colleagues,

Tremendous progress has been made in the development of polymeric materials for biomedical and pharmaceutical applications in recent years. These materials include natural, synthetic and semi-synthetic polymers. These developments have greatly enhanced our understanding of the properties of these materials, which in turn has enabled us to exploit and modify them to suit the prevention and treatment of specific medical conditions. Many of these materials incorporate desirable properties for drug delivery and wound healing, such as versatility, bioresponsiveness, tunability, biocompatibility, manufacturability and sustainability. This special issue aims to celebrate these advances and encourage knowledge sharing to spur further progress in this area. In this special issue, we invite original research articles and comprehensive reviews on the applications of polymers in drug delivery and wound healing.

Dr. Wing Man Lau
Dr. Keng Wooi Ng
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • wound
  • skin
  • drug delivery
  • formulation
  • chitosan
  • hydrogels
  • polymer therapeutics
  • polymer diagnostics
  • polymer chemistry
  • polymers

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Published Papers (1 paper)

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Research

15 pages, 5971 KiB  
Article
The Interplay between Drug and Sorbitol Contents Determines the Mechanical and Swelling Properties of Potential Rice Starch Films for Buccal Drug Delivery
by Bilal Harieth Alrimawi, May Yee Chan, Xin Yue Ooi, Siok-Yee Chan and Choon Fu Goh
Polymers 2021, 13(4), 578; https://doi.org/10.3390/polym13040578 - 15 Feb 2021
Cited by 11 | Viewed by 2839
Abstract
Rice starch is a promising biomaterial for thin film development in buccal drug delivery, but the plasticisation and antiplasticisation phenomena from both plasticisers and drugs on the performance of rice starch films are not well understood. This study aims to elucidate the competing [...] Read more.
Rice starch is a promising biomaterial for thin film development in buccal drug delivery, but the plasticisation and antiplasticisation phenomena from both plasticisers and drugs on the performance of rice starch films are not well understood. This study aims to elucidate the competing effects of sorbitol (plasticiser) and drug (antiplasticiser) on the physicochemical characteristics of rice starch films containing low paracetamol content. Rice starch films were prepared with different sorbitol (10, 20 and 30% w/w) and paracetamol contents (0, 1 and 2% w/w) using the film casting method and were characterised especially for drug release, swelling and mechanical properties. Sorbitol showed a typical plasticising effect on the control rice starch films by increasing film flexibility and by reducing swelling behaviour. The presence of drugs, however, modified both the mechanical and swelling properties by exerting an antiplasticisation effect. This antiplasticisation action was found to be significant at a low sorbitol level or a high drug content. FTIR investigations supported the antiplasticisation action of paracetamol through the disturbance of sorbitol–starch interactions. Despite this difference, an immediate drug release was generally obtained. This study highlights the interplay between plasticiser and drug in influencing the mechanical and swelling characteristics of rice starch films at varying concentrations. Full article
(This article belongs to the Special Issue Polymers for Drug Delivery and Wound Healing)
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