Development of New Polymer Matrix Composites for Medical and Biological Applications

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biomacromolecules, Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: closed (25 September 2022) | Viewed by 2965

Special Issue Editor


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Guest Editor
Institute of Chemistry and Problems of Sustainable Development, Mendeleev University of Chemical Technology of Russia, Moscow 125047, Russia
Interests: conductive polymers; polyaniline; polypyrrole; oxidative polymerization; biomaterials; polymerization kinetics; conductive nanocomposites
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Special Issue Information

Dear Colleagues,

The production of composites with a polymer matrix opens up promising prospects for the development of new implants and endoprostheses, systems with controlled release of pharmacologically active drugs, materials for soft tissue replacement, as well as muscle imitation and determination of metabolite concentrations. At the same time, the use of polymers and composite materials with a polymer matrix in biomedical fields imposes specific requirements on materials, such as the absence of significant toxicity, biocompatibility, biodegradability, and the capacity to release immobilized drugs at a controlled rate.

The purpose of this Special Issue is to collect results on the preparation and use of polymer composite materials in medicine and biology, as well as on the synthesis of new promising macromolecules for the pharmaceutical science.

Original and review manuscripts dedicated to the problems of the preparation and application of hydrogels, polymer materials used for production of implants and endoprostheses, macromolecular drugs carriers, as well as biodegradable materials, are welcome. The development of hemocompatible materials and amphiphilic polymers for pharmacological applications, control of the rate of biodegradation of polymers, pharmacokinetics, composites based on biopolymers, imitation of soft tissues and muscles, creation of biosensors are also the subject of this Special Issue. Priority will be given to manuscripts showing the relationship between the structure of macromolecules and polymer composites and their properties that determine the prospects for application in medicine and biology.

Dr. Yaroslav O. Mezhuev
Guest Editor

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Published Papers (1 paper)

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Research

14 pages, 3440 KiB  
Article
Synthesis of Amphiphilic Copolymers of N-Vinyl-2-pyrrolidone and Allyl Glycidyl Ether for Co-Delivery of Doxorubicin and Paclitaxel
by Anna Nechaeva, Alexander Artyukhov, Anna Luss, Mikhail Shtilman, Inessa Gritskova, Anton Shulgin, Mikhail Motyakin, Irina Levina, Efrem Krivoborodov, Ilya Toropygin, Evgeniy Chistyakov, Leonid Gurevich and Yaroslav Mezhuev
Polymers 2022, 14(9), 1727; https://doi.org/10.3390/polym14091727 - 23 Apr 2022
Cited by 8 | Viewed by 2565
Abstract
Co-delivery of chemotherapeutics in cancer treatment has been proven essential for overcoming multidrug resistance and improving the outcome of therapy. We report the synthesis of amphiphilic copolymers of N-vinyl-2-pyrrolidone and allyl glycidyl ether of various compositions and demonstrate that they can form [...] Read more.
Co-delivery of chemotherapeutics in cancer treatment has been proven essential for overcoming multidrug resistance and improving the outcome of therapy. We report the synthesis of amphiphilic copolymers of N-vinyl-2-pyrrolidone and allyl glycidyl ether of various compositions and demonstrate that they can form nanoaggregates capable of simultaneous covalent immobilization of doxorubicin by the epoxy groups in the shell and hydrophobic-driven incorporation of paclitaxel into the core of nanoparticles. The structure of the obtained copolymers was characterized by 13C NMR, IR, and MALDI spectroscopy, as well as adsorption at the water/toluene interface. A linear increase in the number-average molecular weight of amphiphilic copolymers and a decrease in the number-average diameter of macromolecular aggregates with an increase in the ratio N-vinyl-2-pyrrolidone/allyl glycidyl ether were observed. The assembled nanocarriers were characterized by DLS. The reported novel nanocarriers can be of interest for delivery and co-delivery of a wide range of pharmacological preparations and combined therapy for cancer and other deceases. Full article
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