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Polymers
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Development and Characterization of Next-Generation Biomaterials from Basic to Bench...
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Development and Characterization of Next-Generation Biomaterials from Basic to Bench Research

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biomacromolecules, Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: closed (10 November 2022) | Viewed by 11949

Special Issue Editors

Prof. Dr. Akon Higuchi

E-Mail Website1 Website2
Guest Editor
Department of Chemical and Materials Engineering, National Central University, No. 300, Jhongda RD., Jhongli, Taoyuan 32001, Taiwan
Interests: biomaterials; cell culture and differentiation; stem cell; surface modification; scaffold
Prof. Dr. Jen-Ming Yang

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Guest Editor
Department of Chemical and Materials Engineering, Chang Gung University, Taoyuan City 33302, Taiwan
Interests: biomaterials; compatible polymers; polymeric scaffold; tissue engineering; polymer science
Dr. Yingying Du

E-Mail Website
Guest Editor
Advanced Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan 310000, China
Interests: biomaterials; tissue engineering; polymeric scaffold; composite scaffold; 3D printing

Special Issue Information

Dear Colleagues,

Biomaterials are used for medical devices, cell culture (including stem cells and primary tissue cells), and drug production. For this Special Issue, we welcome the submission of manuscripts related to biomaterial investigation at all stages, from basic research to bench research. Biomaterials of special interest include biomaterials for biosensor and diagnosis, biomaterials used in vaccine production (especially biomaterials used for SARS-CoV-2 vaccines), scaffolds for tissue engineering, cell culture biomaterials for stem cell or tissue cell culture and differentiation, and biomaterials for virus removal filters and blood purification in the current and next generations. However, we welcome any manuscripts related to biomaterials that will be used as “next-generation biomaterials”.

Prof. Dr. Akon Higuchi
Prof. Dr. Jen-Ming Yang
Dr. Yingying Du
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Biomaterials
  • Cell culture
  • Cell differentiation
  • Stem cell
  • Surface modification
  • Scaffold
  • Tissue engineering
  • Hydrogels
  • 3D printing
  • Biopolymer
  • Extracellular matrix
  • Peptide
  • Biointerface
  • Bioceramics
  • Biodegradable polymer

Published Papers (4 papers)

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Research

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14 pages, 3346 KiB  
Article
Precise Fabrication of Porous Microspheres by Iso-Density Emulsion Combined with Microfluidics
by Yuxiao Shi, Xin Zhang, Ketao Mu, Yifan Wang, Ting Jiang, Shangtong Jiang, Shengmin Zhang and Yingying Du
Polymers 2022, 14(13), 2687; https://doi.org/10.3390/polym14132687 - 30 Jun 2022
Cited by 2 | Viewed by 2996
Abstract
Polymer porous microspheres with large specific surface areas and good fluidity have promising important applications in the biomedical field. However, controllable fabrication of porous microspheres with precise size, morphology, and pore structure is still a challenge, and phase separation caused by the instability [...] Read more.
Polymer porous microspheres with large specific surface areas and good fluidity have promising important applications in the biomedical field. However, controllable fabrication of porous microspheres with precise size, morphology, and pore structure is still a challenge, and phase separation caused by the instability of the emulsion is the main factor affecting the precise preparation of porous microspheres. Herein, a method combining the iso-density emulsion (IDE) template and microfluidics was proposed to realize the controllable preparation of polymer porous microspheres. The IDE exhibited excellent stability with minimal phase separation within 4 h, thus showing potential advantages in the large-scale preparation of porous microspheres. With the IDE template combined microfluidics technique and the use of a customized amphoteric copolymer, PEG-b-polycaprolactone, polycaprolactone (PCL) porous microspheres with porosity higher than 90% were successfully prepared. Afterwards, the main factors, including polymer concentration, water–oil ratio and homogenization time were investigated to regulate the pore structure of microspheres, and microspheres with different pore sizes (1–30 μm) were obtained. PCL porous microspheres exhibited comparable cell viability relative to the control group and good potential as cell microcarriers after surface modification with polydopamine. The modified PCL porous microspheres implanted subcutaneously in rats underwent rapid in vivo degradation and tissue ingrowth. Overall, this study demonstrated an efficient strategy for the precise preparation of porous microspheres and investigated the potential of the as-prepared PCL porous microspheres as cell microcarriers and micro-scaffolds. Full article
(This article belongs to the Special Issue Development and Characterization of Next-Generation Biomaterials from Basic to Bench Research)
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11 pages, 50519 KiB  
Article
Thermal and Flame Retardant Behavior of Neem and Banyan Fibers When Reinforced with a Bran Particulate Epoxy Hybrid Composite
by Thandavamoorthy Raja, Vinayagam Mohanavel, Thanikodi Sathish, Sinouvassane Djearamane, Palanivel Velmurugan, Alagar Karthick, Omaima Nasif, Saleh Alfarraj, Ling Shing Wong, Shanmugam Sureshkumar and Manikkam Ravichandran
Polymers 2021, 13(22), 3859; https://doi.org/10.3390/polym13223859 - 9 Nov 2021
Cited by 21 | Viewed by 2534
Abstract
Awareness of environmental concerns influences researchers to develop an alternative method of developing natural fiber composite materials, to reduce the consumption of synthetic fibers. This research attempted testing the neem (Azadirachta indica) fiber and the banyan (Ficus benghalensis) fiber [...] Read more.
Awareness of environmental concerns influences researchers to develop an alternative method of developing natural fiber composite materials, to reduce the consumption of synthetic fibers. This research attempted testing the neem (Azadirachta indica) fiber and the banyan (Ficus benghalensis) fiber at different weight fractions, under flame retardant and thermal testing, in the interest of manufacturing efficient products and parts in real-time applications. The hybrid composite consists of 25% fiber reinforcement, 70% matrix material, and 5% bran filler. Their thermal properties—short-term heat deflection, temperature, thermal conductivity, and thermal expansion—were used to quantify the effect of potential epoxy composites. Although natural composite materials are widely utilized, their uses are limited since many of them are combustible. As a result, there has been a lot of focus on making them flame resistant. The thermal analysis revealed the sample B was given 26% more short-term heat resistance when the presence of banyan fiber loading is maximum. The maximum heat deflection temperature occurred in sample A (104.5 °C) and sample B (99.2 °C), which shows a 36% greater thermal expansion compared with chopped neem fiber loading. In sample F, an increased chopped neem fiber weight fraction gave a 40% higher thermal conductivity, when compared to increasing the bidirectional banyan mat of this hybrid composite. The maximum flame retardant capacity occurred in samples A and B, with endurance up to 12.9 and 11.8 min during the flame test of the hybrid composites. Full article
(This article belongs to the Special Issue Development and Characterization of Next-Generation Biomaterials from Basic to Bench Research)
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19 pages, 5777 KiB  
Article
Purification of Colon Carcinoma Cells from Primary Colon Tumor Using a Filtration Method via Porous Polymeric Filters
by Jia-Hua Wang, Lee-Kiat Ban, Henry Hsin-Chung Lee, Yen-Hung Chen, Hui-Yu Lin, Zhe-Wei Zhu, Her-Young Su, Akihiro Umezawa, Abdulrahman I. Almansour, Natarajan Arumugam, Raju Suresh Kumar, Gwo-Jang Wu and Akon Higuchi
Polymers 2021, 13(19), 3411; https://doi.org/10.3390/polym13193411 - 5 Oct 2021
Viewed by 2582
Abstract
Cancer stem cells (CSCs) or cancer-initiating cells (CICs) are key factors for tumor generation and metastasis. We investigated a filtration method to enhance CSCs (CICs) from colon carcinoma HT-29 cells and primary colon carcinoma cells derived from patient colon tumors using poly(lactide-co [...] Read more.
Cancer stem cells (CSCs) or cancer-initiating cells (CICs) are key factors for tumor generation and metastasis. We investigated a filtration method to enhance CSCs (CICs) from colon carcinoma HT-29 cells and primary colon carcinoma cells derived from patient colon tumors using poly(lactide-co-glycolic acid)/silk screen (PLGA/SK) filters. The colon carcinoma cell solutions were permeated via porous filters to obtain a permeation solution. Then, the cell cultivation media were permeated via the filters to obtain the recovered solution, where the colon carcinoma cells that adhered to the filters were washed off into the recovered solution. Subsequently, the filters were incubated in the culture media to obtain the migrated cells via the filters. Colon carcinoma HT-29 cells with high tumorigenicity, which might be CSCs (CICs), were enhanced in the cells in the recovered solution and in the migrated cells based on the CSC (CIC) marker expression, colony-forming unit assay, and carcinoembryonic antigen (CEA) production. Although primary colon carcinoma cells isolated from colon tumor tissues contained fibroblast-like cells, the primary colon carcinoma cells were purified from fibroblast-like cells by filtration through PLGA/SK filters, indicating that the filtration method is effective in purifying primary colon carcinoma cells. Full article
(This article belongs to the Special Issue Development and Characterization of Next-Generation Biomaterials from Basic to Bench Research)
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Review

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20 pages, 1960 KiB  
Review
A Promising Review on Cyclodextrin Conjugated Paclitaxel Nanoparticles for Cancer Treatment
by Kamini Velhal, Sagar Barage, Arpita Roy, Jaya Lakkakula, Ramesh Yamgar, Mohammed S. Alqahtani, Krishna Kumar Yadav, Yongtae Ahn and Byong-Hun Jeon
Polymers 2022, 14(15), 3162; https://doi.org/10.3390/polym14153162 - 3 Aug 2022
Cited by 9 | Viewed by 2552
Abstract
This review presented the unique characteristics of different types of cyclodextrin polymers by non-covalent host–guest interactions to synthesize an inclusion complex. Various cancers are treated with different types of modified cyclodextrins, along with the anticancer drug paclitaxel. PTX acts as a mitotic inhibitor, [...] Read more.
This review presented the unique characteristics of different types of cyclodextrin polymers by non-covalent host–guest interactions to synthesize an inclusion complex. Various cancers are treated with different types of modified cyclodextrins, along with the anticancer drug paclitaxel. PTX acts as a mitotic inhibitor, but due to its low dissolution and permeability in aqueous solutions, it causes considerable challenges for drug delivery system (DDS) designs. To enhance the solubility, it is reformulated with derivatives of cyclodextrins using freeze-drying and co-solvent lyophilization methods. The present supramolecular assemblies involve cyclodextrin as a key mediator, which is encapsulated with paclitaxel and their controlled release at the targeted area is highlighted using different DDS. In addition, the application of cyclodextrins in cancer treatment, which reduces the off-target effects, is briefly demonstrated using various types of cancer cell lines. A new nano-formulation of PTX is used to improve the antitumor activity compared to normal PTX DDS in lungs and breast cancer is well defined in the present review. Full article
(This article belongs to the Special Issue Development and Characterization of Next-Generation Biomaterials from Basic to Bench Research)
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