Cancer Metastasis and Drug Development for Cancer
A special issue of Processes (ISSN 2227-9717). This special issue belongs to the section "Pharmaceutical Processes".
Deadline for manuscript submissions: closed (15 November 2023)
Special Issue Editor
Interests: onco-ematology; rare diseases; drug development; drug repurposing; drug access
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleague
Metastasis is associated with a poor prognosis and is the main cause of oncologic patient death.
The metastatic process is characterized by high complexity, with different driving mutations, variable localization, and extracellular and cellular composition compared to the primary site. Therefore, metastases should be considered biologically different from the primary tumour.
Despite the advent of effective new therapies within the past decade, such as immunotherapy, the majority of patients with advanced disease die as a direct result of metastasis or due to complications of treatment.
Indeed, new effective treatment strategies have been developed on the basis of evidence of anticancer activity but not of metastatic activity.
Moreover, poor evidence from preclinical and/or clinical studies exists for agents targeting the biological mechanisms underlying the metastatic process.
New therapeutic strategies with an anti-metastatic mechanisms of action must be developed to met this clinical need.
In recent years, potential targets with anti-metastatic activity have been identified for drug discovery and development but need to be validated using appropriate preclinical models and in clinical trials, thanks to the support of regulatory agencies.
This Special Issue aims to curate the latest advances in the development of molecules with anti-metastatic properties to address the high unmet medical need of oncologic diseases.
Topics include, but are not limited to:
-Preclinical studies;
-Clinical studies;
-Regulatory issues.
Dr. Lucia Gozzo
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Processes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cancer
- metastasis
- target therapy
- immunotherapy
- preclinical evidence
- clinical evidence
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