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Electrochemical Sensors and Biosensors Based on Graphene

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Chemical Sensors".

Deadline for manuscript submissions: 15 October 2024 | Viewed by 1395

Special Issue Editors


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Guest Editor
U.S. Naval Research Laboratory, 4555 Overlook Ave. SW, Washington, DC 20375, USA
Interests: chemical vapor sensors; carbon nanotubes; nanolithography

E-Mail Website
Guest Editor
U.S. Naval Research Laboratory, 4555 Overlook Avenue SW, Washington, DC 20375, USA
Interests: epitaxial growth of SiC via chemical vapor deposition; investigations of extended and point defects; synthesis of epitaxial graphene

Special Issue Information

Dear Colleagues,

Graphene films have proven remarkably useful for biosensing applications, typically but not exclusively employing an electrochemical approach, where electrolyte displacement from the film during a binding event induces an easily measured change in its properties. However, while the literature on this topic is quite exhaustive, the commercial application of graphene film sensors has been slow. This Special Issue aims to explore the factors that hinder their development.

We seek papers exploring the following:

  • Film selection (exfoliated, epitaxial, or CVD);
  • Functionalization (linker molecules or direct attachment);
  • Methods of use (field-induced conductivity modulation, capacitance, optical spectroscopy, etc.);
  • Performance (sensitivity, specificity, or specific responses);
  • Stability (shelf life, working life, corrosion resistance, and methods of improvement).

Of additional interest is the comparison of these sensors to alternative or more traditional transducers, as well as business models for their commercialization. 

Dr. Perkins F. Keith
Dr. Myers-Ward Rachael
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • graphene
  • biosensor
  • electrochemistry
  • transducer
  • functionalization

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Published Papers (2 papers)

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20 pages, 6107 KiB  
Article
The Tunable Parameters of Graphene-Based Biosensors
by Talia Tene, Jiří Svozilík, Dennys Colcha, Yesenia Cevallos, Paola Gabriela Vinueza-Naranjo, Cristian Vacacela Gomez and Stefano Bellucci
Sensors 2024, 24(15), 5049; https://doi.org/10.3390/s24155049 - 4 Aug 2024
Viewed by 645
Abstract
Graphene-based surface plasmon resonance (SPR) biosensors have emerged as a promising technology for the highly sensitive and accurate detection of biomolecules. This study presents a comprehensive theoretical analysis of graphene-based SPR biosensors, focusing on configurations with single and bimetallic metallic layers. In this [...] Read more.
Graphene-based surface plasmon resonance (SPR) biosensors have emerged as a promising technology for the highly sensitive and accurate detection of biomolecules. This study presents a comprehensive theoretical analysis of graphene-based SPR biosensors, focusing on configurations with single and bimetallic metallic layers. In this study, we investigated the impact of various metallic substrates, including gold and silver, and the number of graphene layers on key performance metrics: sensitivity of detection, detection accuracy, and quality factor. Our findings reveal that configurations with graphene first supported on gold exhibit superior performance, with sensitivity of detection enhancements up to 30% for ten graphene layers. In contrast, silver-supported configurations, while demonstrating high sensitivity, face challenges in maintaining detection accuracy. Additionally, reducing the thickness of metallic layers by 30% optimizes light coupling and enhances sensor performance. These insights highlight the significant potential of graphene-based SPR biosensors in achieving high sensitivity of detection and reliability, paving the way for their application in diverse biosensing technologies. Our findings pretend to motivate future research focusing on optimizing metallic layer thickness, improving the stability of silver-supported configurations, and experimentally validating the theoretical findings to further advance the development of high-performance SPR biosensors. Full article
(This article belongs to the Special Issue Electrochemical Sensors and Biosensors Based on Graphene)
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39 pages, 2910 KiB  
Systematic Review
Role of Graphene in Surface Plasmon Resonance-Based Biosensors
by Talia Tene, Stefano Bellucci, Fabian Arias Arias, Luis Santiago Carrera Almendariz, Ana Gabriela Flores Huilcapi and Cristian Vacacela Gomez
Sensors 2024, 24(14), 4670; https://doi.org/10.3390/s24144670 - 18 Jul 2024
Viewed by 551
Abstract
This work explores the transformative role of graphene in enhancing the performance of surface plasmon resonance (SPR)-based biosensors. The motivation for this review stems from the growing interest in the unique properties of graphene, such as high surface area, excellent electrical conductivity, and [...] Read more.
This work explores the transformative role of graphene in enhancing the performance of surface plasmon resonance (SPR)-based biosensors. The motivation for this review stems from the growing interest in the unique properties of graphene, such as high surface area, excellent electrical conductivity, and versatile functionalization capabilities, which offer significant potential to improve the sensitivity, specificity, and stability of SPR biosensors. This review systematically analyzes studies published between 2010 and 2023, covering key metrics of biosensor performance. The findings reveal that the integration of graphene consistently enhances sensitivity. Specificity, although less frequently reported numerically, showed promising results, with high specificity achieved at sub-nanomolar concentrations. Stability enhancements are also significant, attributed to the protective properties of graphene and improved biomolecule adsorption. Future research should focus on mechanistic insights, optimization of integration techniques, practical application testing, scalable fabrication methods, and comprehensive comparative studies. Our findings provide a foundation for future research, aiming to further optimize and harness the unique physical properties of graphene to meet the demands of sensitive, specific, stable, and rapid biosensing in various practical applications. Full article
(This article belongs to the Special Issue Electrochemical Sensors and Biosensors Based on Graphene)
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