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Electronic, Mass-Sensitive and Thermal Transducers for Bio- and Chemosensing
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Electronic, Mass-Sensitive and Thermal Transducers for Bio- and Chemosensing

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biosensors".

Deadline for manuscript submissions: 30 April 2025 | Viewed by 3554

Special Issue Editors

Prof. Dr. Michael J. Schöning

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Guest Editor
Director, Institute of Nano- and Biotechnologies, Aachen University of Applied Sciences, Heinrich-Mußmann-Str. 1, 52428 Jülich, Germany
Interests: silicon-based chemical sensors; label-free biosensing; field-effect devices; micro- and nanosystem technology; sensor applications
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Sven Ingebrandt

E-Mail Website
Guest Editor
Director, Institute of Materials in Electrical Engineering 1, RWTH Aachen University, Sommerfeldstr. 24, 52074 Aachen, Germany
Interests: biosensors; bioelectronics; field-effect transistors; nanowires; 2D materials; wearables; neuroimplants; micro- and nanosystems
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Patrick Wagner

E-Mail Website
Guest Editor
Laboratory for Soft Matter and Biophysics, Department of Physics and Astronomy, KU Leuven, Leuven, Belgium
Interests: bio- and chemosensors; synthetic bioreceptors; label-free transducer principles; medical diagnostics; food-safety analysis; environmental monitoring
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In 2022, we successfully launched the Special Issue “Field-Effect Sensors: From pH Sensing to Biosensing”, compiling 12 articles that showcased a broad spectrum of different types of field-effect devices for chemical sensing and biosensing.

To expand this highly interesting topic towards other “electronic-based” detection methods, the new Special Issue is devoted to “Electronic, Mass-Sensitive, and Thermal Transducers for Bio- and Chemosensing”. As well as the fundamental aspects of sensing methods and principles, the Special Issue seeks to also address the broad range of sensor applications, providing an overview state-of-the-art technologies. The topics may include, but are not exclusively related to, the following:

  • Device concepts for electronic, mass-sensitive, and thermal transducers;
  • Single sensors, multiparametric sensors, and sensor arrays;
  • Modelling and theory of electronic, mass-sensitive, and thermal transducers;
  • Applications for biosensors in biomedical analysis, food control, environmental monitoring, and the characterization of biomaterials and biomolecular interactions.

Prof. Dr. Michael J. Schöning
Prof. Dr. Sven Ingebrandt
Prof. Dr. Patrick Wagner
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • transducers
  • sensors
  • biosensors
  • chemosensors
  • electronic
  • sensor application

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Published Papers (4 papers)

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Research

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15 pages, 5252 KiB  
Article
Assessing the Quality of Solvent-Assisted Lipid Bilayers Formed at Different Phases and Aqueous Buffer Media: A QCM-D Study
by Marta Lavrič, Laure Bar, Martin E. Villanueva, Patricia Losada-Pérez, Aleš Iglič, Nikola Novak and George Cordoyiannis
Sensors 2024, 24(18), 6093; https://doi.org/10.3390/s24186093 - 20 Sep 2024
Viewed by 487
Abstract
Supported lipid bilayers (SLBs) are low-complexity biomimetic membranes, serving as popular experimental platforms to study membrane organization and lipid transfer, membrane uptake of nanoparticles and biomolecules, and many other processes. Quartz crystal microbalance with dissipation monitoring has been utilized to probe the influence [...] Read more.
Supported lipid bilayers (SLBs) are low-complexity biomimetic membranes, serving as popular experimental platforms to study membrane organization and lipid transfer, membrane uptake of nanoparticles and biomolecules, and many other processes. Quartz crystal microbalance with dissipation monitoring has been utilized to probe the influence of several parameters on the quality of SLBs formed on Au- and SiO2-coated sensors. The influence of the aqueous medium (i.e., buffer type) and the adsorption temperature, above and below the lipid melting point, is neatly explored for SLBs of 1,2-dimyristoyl-sn-glycero-3-phosphocholine and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine formed by a solvent exchange. Below the lipid melting temperature, quality variations are observed upon the formation on Au and SiO2 surfaces, with the SLBs being more homogeneous for the latter. We further investigate how the buffer affects the detection of lipid melting in SLBs, a transition that necessitates high-sensitivity and time-consuming surface-sensitive techniques to be detected. Full article
(This article belongs to the Special Issue Electronic, Mass-Sensitive and Thermal Transducers for Bio- and Chemosensing)
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14 pages, 4122 KiB  
Article
Control Circuits for Potentiostatic/Galvanostatic Polarization and Simultaneous Chemical Sensing by a Light-Addressable Potentiometric Sensor
by Tatsuo Yoshinobu, Rintaro Ikeda and Ko-ichiro Miyamoto
Sensors 2024, 24(17), 5666; https://doi.org/10.3390/s24175666 - 30 Aug 2024
Viewed by 424
Abstract
A light-addressable potentiometric sensor (LAPS) is a semiconductor-based sensor platform for sensing and imaging of various chemical species. Being a potentiometric sensor, no faradaic current flows through its sensing surface, and no electrochemical reaction takes place in the course of LAPS measurement. In [...] Read more.
A light-addressable potentiometric sensor (LAPS) is a semiconductor-based sensor platform for sensing and imaging of various chemical species. Being a potentiometric sensor, no faradaic current flows through its sensing surface, and no electrochemical reaction takes place in the course of LAPS measurement. In this study, a four-electrode system is proposed, in which a LAPS is combined with the conventional three-electrode electrochemical system. A LAPS is included as the fourth electrode for potentiometric sensing and imaging of the target analyte in the course of an electrochemical reaction taking place on the surface of the working electrode. The integrated system will be useful for analyzing dynamic processes, where both the electrochemical process on the electrode surface and the ion distribution in the solution need to be simultaneously investigated. Different grounding modes of control circuits that can simultaneously conduct potentiostatic/galvanostatic polarization and LAPS measurement are designed, and their functionalities are tested. The interference between polarization and LAPS measurement will also be discussed. Full article
(This article belongs to the Special Issue Electronic, Mass-Sensitive and Thermal Transducers for Bio- and Chemosensing)
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14 pages, 3298 KiB  
Article
Microscale Sensor Arrays for the Detection of Dopamine Using PEDOT:PSS Organic Electrochemical Transistors
by Chunling Li, Yingying He, Sven Ingebrandt and Xuan Thang Vu
Sensors 2024, 24(16), 5244; https://doi.org/10.3390/s24165244 - 14 Aug 2024
Viewed by 704
Abstract
We present a sensor array of microscale organic electrochemical transistors (OECTs) using poly (3,4−ethylenedioxythiophene):poly(styrenesulfonic acid) (PEDOT:PSS) as the channel material. The devices show high sensitivity and selectivity to detect dopamine (DA) with platinum (Pt) as a pseudo−reference gate electrode. First, we describe the [...] Read more.
We present a sensor array of microscale organic electrochemical transistors (OECTs) using poly (3,4−ethylenedioxythiophene):poly(styrenesulfonic acid) (PEDOT:PSS) as the channel material. The devices show high sensitivity and selectivity to detect dopamine (DA) with platinum (Pt) as a pseudo−reference gate electrode. First, we describe the wafer−scale fabrication process for manufacturing the PEDOT:PSS OECTs, and then we introduce a dilution method to adjust the thickness of the PEDOT:PSS film. Next, we investigate the effect of the film thickness on the sensitivity of DA detection. Reducing the film thickness enhances the sensitivity of DA detection within the concentration range of 1 μM to 100 μM. The OECTs show impressive sensitivitywith a limit of detection (LoD) as low as 1 nM and a high selectivity against uric acid (UA) and ascorbic acid (AA). Finally, we modify the surface of the Pt gate electrode with chitosan to improve the selectivity of OECTs at high concentrations of up to 100 µM to expand the detection range. Full article
(This article belongs to the Special Issue Electronic, Mass-Sensitive and Thermal Transducers for Bio- and Chemosensing)
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Review

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27 pages, 5737 KiB  
Review
Electrochemical Sensors for Antibiotic Detection: A Focused Review with a Brief Overview of Commercial Technologies
by Margaux Frigoli, Mikolaj P. Krupa, Geert Hooyberghs, Joseph W. Lowdon, Thomas J. Cleij, Hanne Diliën, Kasper Eersels and Bart van Grinsven
Sensors 2024, 24(17), 5576; https://doi.org/10.3390/s24175576 - 28 Aug 2024
Viewed by 1626
Abstract
Antimicrobial resistance (AMR) poses a significant threat to global health, powered by pathogens that become increasingly proficient at withstanding antibiotic treatments. This review introduces the factors contributing to antimicrobial resistance (AMR), highlighting the presence of antibiotics in different environmental and biological matrices as [...] Read more.
Antimicrobial resistance (AMR) poses a significant threat to global health, powered by pathogens that become increasingly proficient at withstanding antibiotic treatments. This review introduces the factors contributing to antimicrobial resistance (AMR), highlighting the presence of antibiotics in different environmental and biological matrices as a significant contributor to the resistance. It emphasizes the urgent need for robust and effective detection methods to identify these substances and mitigate their impact on AMR. Traditional techniques, such as liquid chromatography-mass spectrometry (LC-MS) and immunoassays, are discussed alongside their limitations. The review underscores the emerging role of biosensors as promising alternatives for antibiotic detection, with a particular focus on electrochemical biosensors. Therefore, the manuscript extensively explores the principles and various types of electrochemical biosensors, elucidating their advantages, including high sensitivity, rapid response, and potential for point-of-care applications. Moreover, the manuscript investigates recent advances in materials used to fabricate electrochemical platforms for antibiotic detection, such as aptamers and molecularly imprinted polymers, highlighting their role in enhancing sensor performance and selectivity. This review culminates with an evaluation and summary of commercially available and spin-off sensors for antibiotic detection, emphasizing their versatility and portability. By explaining the landscape, role, and future outlook of electrochemical biosensors in antibiotic detection, this review provides insights into the ongoing efforts to combat the escalating threat of AMR effectively. Full article
(This article belongs to the Special Issue Electronic, Mass-Sensitive and Thermal Transducers for Bio- and Chemosensing)
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