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Affinity-Based Sensors
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Affinity-Based Sensors

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biosensors".

Deadline for manuscript submissions: closed (25 February 2023) | Viewed by 16174

Special Issue Editors

Prof. Dr. Arunas Ramanavicius

E-Mail Website
Guest Editor
NanoTechnas—Center of Nanotechnology and Materials Science, Faculty of Chemistry and Geosciences, Vilnius University, Naugarduko Str. 24, LT-03225 Vilnius, Lithuania
Interests: electrochemistry; bioelectrochemistry; molecularly imprinted polymers; conducting polymers; electrochemical sensors; electrochemical deposition
Special Issues, Collections and Topics in MDPI journals
Dr. Inga Morkvenaite-Vilkonciene

E-Mail Website
Guest Editor
1. Department of Mechatronics, Robotics, and Digital Manufacturing, Vilnius Gediminas Technical University, J. Basanaviciaus Str. 28, LT-03224 Vilnius, Lithuania
2. Laboratory of Electrochemical Energy Conversion, Center for Physical Sciences and Technology, Sauletekio Av. 3, LT-10257 Vilnius, Lithuania
Interests: biosensor; biofuel cell design; scanning electrochemical microscopy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is dedicated to articles on the development and application of various affinity-based sensors, which can be applied for various analytical and bioanalytical applications, including biomedical analysis, food, and beverage control, etc. These sensors can be well integrated with electrochromic devices, organic electronics, bioelectronics, biomedical devices, sensors, biosensors, etc. Recently, significant attention has been paid to the development of sensors (immunosensors and RNA/DNA sensors) for the diagnosis of COVID-19, and/or for the determination of some of the structures through which the SARS-CoV-2 virus consists. Articles about the other affinity sensors are also welcome. Research addressing the development of immunosensors based on conducting polymers and/or on the application of ion-selective electrodes will also be accepted with great pleasure. The application of synthetic receptors and molecularly imprinted polymers seems to be very promising for the development of affinity sensors; therefore, we are accepting articles from synthetic receptor and molecularly imprinted polymer related research.

Prof. Dr. Arunas Ramanavicius
Dr. Inga Morkvenaite-Vilkonciene
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • affinity biosensors
  • immunosensors
  • DNA-sensors
  • synthetic receptors
  • molecularly imprinted polymers
  • ion-selective electrodes
  • conducting polymers
  • conjugated polymers
  • surface plasmon resonance
  • ellipsometry
  • biomacromolecules
  • polypyrrole
  • polyaniline
  • PEDOT
  • biosensors
  • nanomaterials
  • gold nanoparticles
  • carbon-based nanostructures
  • immunosensors

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Published Papers (4 papers)

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Research

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19 pages, 3991 KiB  
Article
A Holistic 4D Approach to Optimize Intrinsic and Extrinsic Factors Contributing to Variability in Microarray Biosensing in Glycomics
by Paras H. Kundalia, Lucia Pažitná, Kristína Kianičková, Eduard Jáné, Lenka Lorencová and Jaroslav Katrlík
Sensors 2023, 23(12), 5362; https://doi.org/10.3390/s23125362 - 6 Jun 2023
Cited by 1 | Viewed by 1663
Abstract
Protein–carbohydrate interactions happen to be a crucial facet of biology, discharging a myriad of functions. Microarrays have become a premier choice to discern the selectivity, sensitivity and breadth of these interactions in a high-throughput manner. The precise recognition of target glycan ligands among [...] Read more.
Protein–carbohydrate interactions happen to be a crucial facet of biology, discharging a myriad of functions. Microarrays have become a premier choice to discern the selectivity, sensitivity and breadth of these interactions in a high-throughput manner. The precise recognition of target glycan ligands among the plethora of others is central for any glycan-targeting probe being tested by microarray analyses. Ever since the introduction of the microarray as an elemental tool for high-throughput glycoprofiling, numerous distinct array platforms possessing different customizations and assemblies have been developed. Accompanying these customizations are various factors ushering variances across array platforms. In this primer, we investigate the influence of various extrinsic factors, namely printing parameters, incubation procedures, analyses and array storage conditions on the protein–carbohydrate interactions and evaluate these factors for the optimal performance of microarray glycomics analysis. We hereby propose a 4D approach (Design–Dispense–Detect–Deduce) to minimize the effect of these extrinsic factors on glycomics microarray analyses and thereby streamline cross-platform analyses and comparisons. This work will aid in optimizing microarray analyses for glycomics, minimize cross-platform disparities and bolster the further development of this technology. Full article
(This article belongs to the Special Issue Affinity-Based Sensors)
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13 pages, 2933 KiB  
Article
VH-Based Mini Q-Body: A Novel Quench-Based Immunosensor
by Jinhua Dong, Bhagat Banwait, Hiroshi Ueda and Peter Kristensen
Sensors 2023, 23(4), 2251; https://doi.org/10.3390/s23042251 - 17 Feb 2023
Cited by 5 | Viewed by 2482
Abstract
Quenchbodies (Q-bodies), a type of biosensor, are antibodies labeled with a fluorescent dye near the antigen recognition site. In the absence of an antigen, the dye is quenched by tryptophans in the antibody sequence; however, in its presence, the dye is displaced and [...] Read more.
Quenchbodies (Q-bodies), a type of biosensor, are antibodies labeled with a fluorescent dye near the antigen recognition site. In the absence of an antigen, the dye is quenched by tryptophans in the antibody sequence; however, in its presence, the dye is displaced and therefore de-quenched. Although scFv and Fab are mainly used to create Q-bodies, this is the first report where a single-domain heavy chain VH from a semi-synthetic human antibody library formed the basis. To create a proof of concept “mini Q-body”, a human anti-lysozyme single-domain VH antibody C3 was used. Mini Q-bodies were successfully developed using seven dyes. Different responses were observed depending on the dye and linker length; it was concluded that the optimal linker length for the TAMRA dye was C5, and rhodamine 6G was identified as the dye with the largest de-quenching response. Three single-domain antibodies with sequences similar to that of the C3 antibody were chosen, and the results confirmed the applicability of this method in developing mini Q-bodies. In summary, mini Q-bodies are an easy-to-use and time-saving method for detecting proteins. Full article
(This article belongs to the Special Issue Affinity-Based Sensors)
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12 pages, 2831 KiB  
Article
Evaluation of a Yeast–Polypyrrole Biocomposite Used in Microbial Fuel Cells
by Antanas Zinovicius, Juste Rozene, Timas Merkelis, Ingrida Bruzaite, Arunas Ramanavicius and Inga Morkvenaite-Vilkonciene
Sensors 2022, 22(1), 327; https://doi.org/10.3390/s22010327 - 2 Jan 2022
Cited by 18 | Viewed by 2688
Abstract
Electrically conductive polymers are promising materials for charge transfer from living cells to the anodes of electrochemical biosensors and biofuel cells. The modification of living cells by polypyrrole (PPy) causes shortened cell lifespan, burdens the replication process, and diminishes renewability in the long [...] Read more.
Electrically conductive polymers are promising materials for charge transfer from living cells to the anodes of electrochemical biosensors and biofuel cells. The modification of living cells by polypyrrole (PPy) causes shortened cell lifespan, burdens the replication process, and diminishes renewability in the long term. In this paper, the viability and morphology non-modified, inactivated, and PPy-modified yeasts were evaluated. The results displayed a reduction in cell size, an incremental increase in roughness parameters, and the formation of small structural clusters of polymers on the yeast cells with the increase in the pyrrole concentration used for modification. Yeast modified with the lowest pyrrole concentration showed minimal change; thus, a microbial fuel cell (MFC) was designed using yeast modified by a solution containing 0.05 M pyrrole and compared with the characteristics of an MFC based on non-modified yeast. The maximal generated power of the modified system was 47.12 mW/m2, which is 8.32 mW/m2 higher than that of the system based on non-modified yeast. The open-circuit potentials of the non-modified and PPy-modified yeast-based cells were 335 mV and 390 mV, respectively. Even though applying a PPy layer to yeast increases the charge-transfer efficiency towards the electrode, the damage done to the cells due to modification with a higher concentration of PPy diminishes the amount of charge transferred, as the current density drops by 846 μA/cm2. This decrease suggests that modification by PPy may have a cytotoxic effect that greatly hinders the metabolic activity of yeast. Full article
(This article belongs to the Special Issue Affinity-Based Sensors)
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Review

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22 pages, 11374 KiB  
Review
Electrochemically Deposited Molecularly Imprinted Polymer-Based Sensors
by Simonas Ramanavičius, Inga Morkvėnaitė-Vilkončienė, Urtė Samukaitė-Bubnienė, Vilma Ratautaitė, Ieva Plikusienė, Roman Viter and Arūnas Ramanavičius
Sensors 2022, 22(3), 1282; https://doi.org/10.3390/s22031282 - 8 Feb 2022
Cited by 48 | Viewed by 7212
Abstract
This review is dedicated to the development of molecularly imprinted polymers (MIPs) and the application of MIPs in sensor design. MIP-based biological recognition parts can replace receptors or antibodies, which are rather expensive. Conducting polymers show unique properties that are applicable in sensor [...] Read more.
This review is dedicated to the development of molecularly imprinted polymers (MIPs) and the application of MIPs in sensor design. MIP-based biological recognition parts can replace receptors or antibodies, which are rather expensive. Conducting polymers show unique properties that are applicable in sensor design. Therefore, MIP-based conducting polymers, including polypyrrole, polythiophene, poly(3,4-ethylenedioxythiophene), polyaniline and ortho-phenylenediamine are frequently applied in sensor design. Some other materials that can be molecularly imprinted are also overviewed in this review. Among many imprintable materials conducting polymer, polypyrrole is one of the most suitable for molecular imprinting of various targets ranging from small organics up to rather large proteins. Some attention in this review is dedicated to overview methods applied to design MIP-based sensing structures. Some attention is dedicated to the physicochemical methods applied for the transduction of analytical signals. Expected new trends and horizons in the application of MIP-based structures are also discussed. Full article
(This article belongs to the Special Issue Affinity-Based Sensors)
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