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Electrochemical Sensors for Determination of Biomolecules

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A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Chemical Sensors".

Deadline for manuscript submissions: closed (20 October 2022) | Viewed by 5687

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Special Issue Editors

Dr. Ilona Sadok

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Guest Editor

Department of Chemistry, Institute of Biological Sciences, Faculty of Medicine, The John Paul II Catholic University of Lublin, 20-708 Lublin, Poland
Interests: development of electrochemical sensors; voltammetric sensors; electrode surface modification; development of analytical approaches for quantitative analysis of biomolecules; biomarker research; liquid chromatography; mass spectrometry; tryptophan metabolism; mycotoxins determination; sample preparation; biofluids analysis; food analysis
Special Issues, Collections and Topics in MDPI journals

Dr. Magdalena Staniszewska

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Guest Editor

Laboratory of Separation and Spectroscopic Method Applications, Centre for Interdisciplinary Research, The John Paul II Catholic University of Lublin, 1J Konstantynów Str., 20-708 Lublin, Poland
Interests: kynurenine pathway; tryptophan metabolites; indoleamine-2,3-dioxygenase; tryptophan-2,3-dioxygenase; immune regulation; cancer development and biomarkers
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The monitoring of biomolecules has attracted much scientific attention due to their importance in multiple physiological and pathological functions within organisms. This class of compounds has been intensively studied to determine their potential roles as biomarkers for the early diagnosis of various diseases or as targets for drug candidates. There is growing demand for faster and more reliable analytical methods that allow for rapid and accurate quantification of biomolecules. Compared with the frequently used analytical methods (liquid and gas chromatography, capillary electrophoresis, mass spectrometry) or immunochemical assays (ELISA), electrochemical sensors offer several inherent advantages, being rapid, affordable, miniaturized, and user-friendly assays. The present Special Issue is dedicated to presenting recent achievements in electrochemical (bio)sensors for the determination of biomolecules. Both review articles and original research papers are welcome. Topics of interest include, but are not limited to, recent developments in the following research areas:

- electrochemical determination of biomolecules;

- electrochemical detection in combination with separation techniques;

- determination on modified and unmodified electrodes;

- fabrication of sensors and new strategies for electrode surface modification;

- improvement of the sensitivity of determination of biomolecules;

- develoments in method selectivity;

- overcoming the interference of co-existence of compounds in real sample analysis;

- new methodologies for sample preparation for electrochemical detection;

- application in the analysis of biological fluids, pharmaceuticals, food and environmental samples.

We look forward to reviewing your submissions for this forthcoming Special Issue.

Dr. Ilona Sadok
Dr. Magdalena Staniszewska
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

electrochemical sensors
biosensors
biomolecules
metabolites
unmodified and modified electrodes
sensor fabrication
analysis of biological fluids
analysis of pharmaceuticals
food analysis
analysis of environmental samples

Published Papers (2 papers)

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Research

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13 pages, 3289 KiB

Open AccessArticle

Cerium(IV) and Iron(III) Oxides Nanoparticles Based Voltammetric Sensor for the Sensitive and Selective Determination of Lipoic Acid

by Guzel Ziyatdinova and Liliya Gimadutdinova

Sensors 2021, 21(22), 7639; https://doi.org/10.3390/s21227639 - 17 Nov 2021

Cited by 11 | Viewed by 1843

Abstract

A novel voltammetric sensor based on CeO₂·Fe₂O₃ nanoparticles (NPs) has been developed for the determination of lipoic acid, playing an essential role in aerobic metabolism in the living organism. Sensor surface modification provides a 5.6-fold increase of the lipoic acid oxidation currents and a 20 mV anodic shift of the oxidation potential. The best voltammetric parameters have been obtained for the 0.5 mg mL⁻¹ dispersion of CeO₂·Fe₂O₃ NPs. Scanning electron microscopy (SEM) confirms the presence of spherical NPs of 25–60 nm, and their aggregates evenly distributed on the electrode surface and formed porous coverage. This leads to the 4.4-fold increase of the effective surface area vs. bare glassy carbon electrode (GCE). The sensor shows a significantly higher electron transfer rate. Electrooxidation of lipoic acid on CeO₂·Fe₂O₃ NPs modified GCE is an irreversible diffusion-controlled pH-independent process occurring with the participation of two electrons. The sensor gives a linear response to lipoic acid in the ranges of 0.075–7.5 and 7.5–100 μM with the detection limit of 0.053 μM. The sensor is selective towards lipoic acid in the presence of inorganic ions, ascorbic acid, saccharides, and other S-containing compounds. The sensor developed has been tested on the pharmaceutical dosage forms of lipoic acid. Full article

(This article belongs to the Special Issue Electrochemical Sensors for Determination of Biomolecules)

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Review

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23 pages, 4753 KiB

Open AccessReview

Electrochemical Determination of Kynurenine Pathway Metabolites—Challenges and Perspectives

by Ilona Sadok and Magdalena Staniszewska

Sensors 2021, 21(21), 7152; https://doi.org/10.3390/s21217152 - 28 Oct 2021

Cited by 9 | Viewed by 2959

Abstract

In recent years, tryptophan metabolism via the kynurenine pathway has become one of the most active research areas thanks to its involvement in a variety of physiological processes, especially in conditions associated with immune dysfunction, central nervous system disorders, autoimmunity, infection, diabetes, and cancer. The kynurenine pathway generates several metabolites with immunosuppressive functions or neuroprotective, antioxidant, or toxic properties. An increasing body of work on this topic uncovers a need for reliable analytical methods to help identify and quantify tryptophan metabolites at physiological concentrations in biological samples of different origins. Recent methodological advances in the fabrication and application of electrochemical sensors promise a rise in the future generation of novel analytical systems. This work summarizes current knowledge and provides important suggestions with respect to direct electrochemical determinations of kynurenine pathway metabolites (kynurenines) in complex biological matrices. Measurement challenges, limitations, and future opportunities of electroanalytical methods to advance study of the implementation of kynurenines in disease conditions are discussed. Full article

(This article belongs to the Special Issue Electrochemical Sensors for Determination of Biomolecules)

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