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Fibre-Optic Biosensing
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Fibre-Optic Biosensing

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biosensors".

Deadline for manuscript submissions: closed (20 August 2021) | Viewed by 13136

Special Issue Editor

Dr. Cosimo Trono

E-Mail Website
Guest Editor
“Nello Carrara” Institute of Applied Physics, IFAC-CNR, Via Madonna del Piano 10, 50019 Firenze, Italy
Interests: optics; optical sensors; fibre optic sensors; point of care testing (POCT)
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Within the field of biosensors, in the last two decades, fiber optic-based biosensing systems have attracted remarkable and growing interest. The well-known advantages offered by fiber optics, such as immunity from electromagnetic fields, intrinsic safety, low invasivity, and excellent optical signal delivery, coupled with the well-established knowledge in the field of biosensing science, could lead to very high-performance biosensing systems.


This Special Issue will focus on the recent developments in the field of fiber optic biosensors. Research articles and reviews focused on the development and innovations in all components and aspects of a fiber optic biosensors are welcome, including, but not restricted to, novel transduction principles, bioreceptors design and optimization for optimal coupling with the fibre optic transducer, innovative fibre optic design, high performance detection schemes, and applications in various analytical fields.

Dr. Trono Cosimo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • fiber optic biosensors
  • label-free
  • label-based
  • surface enhanced Raman spectroscopy
  • fiber optic gratings
  • fiber optic interferometers
  • tapered fiber optics
  • etched fiber optics
  • resonators
  • materials for fiber optic biosensors

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Published Papers (3 papers)

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Research

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11 pages, 1807 KiB  
Article
Sensitive pH Monitoring Using a Polyaniline-Functionalized Fiber Optic—Surface Plasmon Resonance Detector
by Iulia Antohe, Luiza-Izabela Jinga, Vlad-Andrei Antohe and Gabriel Socol
Sensors 2021, 21(12), 4218; https://doi.org/10.3390/s21124218 - 19 Jun 2021
Cited by 17 | Viewed by 3411
Abstract
In this work, we report results on the fabrication and characterization of a surface plasmon resonance (SPR) pH sensor using platinum (Pt) and polyaniline (PANI) layers successively coated over an unclad core of an optical fiber (FO). The plasmonic thin Pt layer was [...] Read more.
In this work, we report results on the fabrication and characterization of a surface plasmon resonance (SPR) pH sensor using platinum (Pt) and polyaniline (PANI) layers successively coated over an unclad core of an optical fiber (FO). The plasmonic thin Pt layer was deposited using a magnetron sputtering technique, while the pH-sensitive PANI layer was synthesized using an electroless polymerization method. Moreover, the formation of PANI film was confirmed by X-ray photoelectron spectroscopy (XPS) technique and its surface morphology was investigated using scanning electron microscopy (SEM). It was found that the PANI/Pt-coated FO-SPR pH sensor exhibits a fast and linear response in either acid or alkali solutions (pH operational range: 1 to 14). The proposed FO-SPR sensor could be used for biomedical applications, environmental monitoring or any remote, real-time on-site measurements. Full article
(This article belongs to the Special Issue Fibre-Optic Biosensing)
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11 pages, 4933 KiB  
Article
Multiplexed Remote SPR Detection of Biological Interactions through Optical Fiber Bundles
by Cloé Desmet, Karim Vindas, Ricardo Alvarado Meza, Patrick Garrigue, Silvia Voci, Neso Sojic, Ali Maziz, Rémi Courson, Laurent Malaquin, Thierry Leichle, Arnaud Buhot, Yoann Roupioz, Loic Leroy and Elodie Engel
Sensors 2020, 20(2), 511; https://doi.org/10.3390/s20020511 - 16 Jan 2020
Cited by 23 | Viewed by 5668
Abstract
The development of sensitive methods for in situ detection of biomarkers is a real challenge to bring medical diagnosis a step forward. The proof-of-concept of a remote multiplexed biomolecular interaction detection through a plasmonic optical fiber bundle is demonstrated here. The strategy relies [...] Read more.
The development of sensitive methods for in situ detection of biomarkers is a real challenge to bring medical diagnosis a step forward. The proof-of-concept of a remote multiplexed biomolecular interaction detection through a plasmonic optical fiber bundle is demonstrated here. The strategy relies on a fiber optic biosensor designed from a 300 µm diameter bundle composed of 6000 individual optical fibers. When appropriately etched and metallized, each optical fiber exhibits specific plasmonic properties. The surface plasmon resonance phenomenon occurring at the surface of each fiber enables to measure biomolecular interactions, through the changes of the retro-reflected light intensity due to light/plasmon coupling variations. The functionalization of the microstructured bundle by multiple protein probes was performed using new polymeric 3D-printed microcantilevers. Such soft cantilevers allow for immobilizing the probes in micro spots, without damaging the optical microstructures nor the gold layer. We show here the potential of this device to perform the multiplexed detection of two different antibodies with limits of detection down to a few tenths of nanomoles per liter. This tool, adapted for multiparametric, real-time, and label free monitoring is minimally invasive and could then provide a useful platform for in vivo targeted molecular analysis. Full article
(This article belongs to the Special Issue Fibre-Optic Biosensing)
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Other

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12 pages, 5573 KiB  
Letter
Chemiluminescent Optical Fiber Immunosensor Combining Surface Modification and Signal Amplification for Ultrasensitive Determination of Hepatitis B Antigen
by Xuexue Xu, Rongbin Nie, Jingwen Huang and Li Yang
Sensors 2020, 20(17), 4912; https://doi.org/10.3390/s20174912 - 31 Aug 2020
Cited by 14 | Viewed by 3079
Abstract
Optical fiber based immunosensors are very attractive for biomarker detection. In order to improve the sensor response, we propose a promising strategy which combines porous-layer modification of the fiber surface and streptavidin-biotin-peroxidase nano-complex signal amplification in chemiluminescent detection. Two hepatitis B antigens, hepatitis [...] Read more.
Optical fiber based immunosensors are very attractive for biomarker detection. In order to improve the sensor response, we propose a promising strategy which combines porous-layer modification of the fiber surface and streptavidin-biotin-peroxidase nano-complex signal amplification in chemiluminescent detection. Two hepatitis B antigens, hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg), are used as the targets for analysis using the proposed sensor. Comparing to immunoassays using normal optical fiber sensors, the response of the present sensor is enhanced by a factor of 4.8 and 6.7 for detection of HBsAg and HBeAg, respectively. The limit-of-quantitation of the proposed method is as low as 0.3 fg/mL (0.01 fg/mL) with a wide linear response range of 3 fg/mL–150 ng/mL (0.1 fg/mL–160 ng/mL) for sensing HBsAg (HBeAg). Quantitative determination of HBsAg and HBeAg in human serum samples is performed, showing the applicability of the proposed method for biomarker detection. Full article
(This article belongs to the Special Issue Fibre-Optic Biosensing)
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