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Nanoparticles for Drug Delivery and Biosensing Applications

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biosensors".

Deadline for manuscript submissions: closed (30 December 2019) | Viewed by 7168

Special Issue Editor


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Guest Editor
Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1N 6N5, Canada
Interests: nanomedicine; drug delivery; nano-biointeractions; biomaterials; targeted drug delivery
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Special Issue Information

Dear Colleagues,

The growing interest in nanotechnology-based applications in medicine is attributed to their uniquely appealing features for drug delivery, imaging, tissue engineering, and medical device development. Several nanotechnology-based therapeutic platforms are either in clinic or under clinical investigation. These platforms have several benefits such as targeted delivery, controlled drug release, ability to encapsulate a wide variety of therapeutic agents, and multi-drug delivery. Recent advances in biomaterials design and synthesis, coupled with a better understanding of nano-bio interactions, enabled the development of more sophisticated platforms. They include, but are not limited to, stimuli response, supramolecular host-guest, redox sensitive, drug delivery sensors, on-demand drug delivery, and guided drug delivery; and their applications range from cancer, cardiovascular diseases, and inflammation, to neurodegenerative diseases.  

The main goal of this Special Issue is to capture the current state-of-the-art and contemporary progress in a variety of nano-biomaterials and nanomedicines development and their different disease applications. Suggested drug-delivery topics are smart platforms, redox active, stimuli-responsive, supramolecular, targeted drug delivery, drug-delivery sensors, and imaging-guided therapeutic platforms. Both research papers and review articles will be considered. If you are interested in contributing to this Special Issue, I would very much appreciate receiving the tentative title of your contribution.

Prof. Suresh Gadde
Guest Editor

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Keywords

  • drug delivery
  • smart materials 
  • stimuli responsive drug delivery 
  • supramolecular biomaterials
  • nanomedicine 
  • multi-functional materials 
  • controlled release 
  • sensors-based drug-delivery 
  • on-demand drug-delivery 
  • biosensors drug delivery

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Published Papers (1 paper)

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Research

12 pages, 3781 KiB  
Article
Colorimetric Analysis of Glucose Oxidase-Magnetic Cellulose Nanocrystals (CNCs) for Glucose Detection
by Ying Chuin Yee, Rokiah Hashim, Ahmad Ramli Mohd Yahya and Yazmin Bustami
Sensors 2019, 19(11), 2511; https://doi.org/10.3390/s19112511 - 31 May 2019
Cited by 30 | Viewed by 6611
Abstract
Glucose oxidase (EC 1.1.3.4) sensors that have been developed and widely used for glucose monitoring have generally relied on electrochemical principle. In this study, the potential use of colorimetric method for glucose detection utilizing glucose oxidase-magnetic cellulose nanocrystals (CNCs) is explored. Magnetic cellulose [...] Read more.
Glucose oxidase (EC 1.1.3.4) sensors that have been developed and widely used for glucose monitoring have generally relied on electrochemical principle. In this study, the potential use of colorimetric method for glucose detection utilizing glucose oxidase-magnetic cellulose nanocrystals (CNCs) is explored. Magnetic cellulose nanocrystals (magnetic CNCs) were fabricated using iron oxide nanoparticles (IONPs) and cellulose nanocrystals (CNCs) via electrostatic self-assembly technique. Glucose oxidase was successfully immobilized on magnetic CNCs using carbodiimide-coupling reaction. About 33% of GOx was successfully attached on magnetic CNCs, and the affinity of GOx-magnetic CNCs to glucose molecules was slightly higher than free enzymes. Furthermore, immobilization does not affect the specificity of GOx-magnetic CNCs towards glucose and can detect glucose from 0.25 mM to 2.5 mM. Apart from that, GOx-magnetic CNCs stored at 4 °C for 4 weeks retained 70% of its initial activity and can be recycled for at least ten consecutive cycles. Full article
(This article belongs to the Special Issue Nanoparticles for Drug Delivery and Biosensing Applications)
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