Nanoimmunosensor
A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biosensors".
Deadline for manuscript submissions: closed (31 August 2020) | Viewed by 33583
Special Issue Editors
Interests: materials; synthesis; characterization; material application for energy harvesting; devices for sensing; optical and electrical devices
Special Issues, Collections and Topics in MDPI journals
Interests: nanoscience and technology
Interests: analytical and bio-analytical chemistry, biosensors, Bio-MEMS, Biochips, microfluidics for chemical and biological analysis, metal speciation, high throughput screening, pesticide residue analysis, aflatoxin detection, antibiotic analysis, milk, water and waste wate analysis, thermal, optical and piezoelectric biosensors, Electrochemical Impedance spectroscopy, enzyme and immunosensors, multianalyte analysis, field portable devices & kits
Special Issue Information
Dear Colleagues,
The synergistic integration of nanomaterials with biosensors has shown tremendous potential with respect to the development of smart devices with wide applications, ranging from chemical sensors to analytical tools for rapid diagnosis and therapeutics.
The unique tunable properties of nanomaterials with easy surface modification provide myriad opportunities for tuning and improving biodevices to achieve desired performance. Particularly, in the case of biosensors, the convenience of surface alterations for easy integration of biorecognition elements onto transducer surfaces broadens the sensing capability of such devices to precisely detect distinctive target biological and chemical species. Needless to say, nanomaterials coupled with surface engineering constitute a powerful toolbox that is capable of designing advanced nanotransducers to meet specific requirements. Nanoimmunosensors, which are basically biosensors that can detect a target species based on antigen–antibody interactions, have undergone tremendous upgrading in terms of signal sensitivity and analytical reliability. Nanotransducers can either directly or indirectly measure on-going immunochemical reactions, producing a proportionate response that can be recorded by electrochemical or optical detection techniques. In the indirect approach, an immune complex is first formed by labeling antibodies or antigens on the transducer’s surface. This immune complex can have different configurations, such as sandwich, competition, and capture configurations, where optical measurements (absorbance, fluorescence, and chemiluminescence) are most often considered for signal detection. On the other hand, in the case of direct detection, which is a label-free protocol, the binding event between the antibody and antigen is registered based on the change or variation in the physicochemical behavior of the transducing material, i.e., resistance change or optical change that can be measured using electrochemical impedance spectroscopy, electrochemical redox chemistry, and surface plasmon resonance (SPR).
Increasing clinical challenges, along with bottleneck issues such as the need to produce nanotransducers that can support greater immobilization while producing a high-throughput detection signal, have initiated a constant search for high-performance immunosensing devices. To achieve this, integrated technologies involving electrochemistry, photochemistry, nanotechnology, and surface engineering are showing tremendous potential while enabling immunosensors to be used in new applications, such as in environmental analysis and the pharmaceuticals, food, and biosecurity industries.
In this Special Issue of Nanoimmunosensor, we seek to bring together researchers from various areas of science working on integrated technologies for the development and engineering of novel, versatile immunosensing platforms with potential applications in, but not limited to, clinical analysis, therapeutics, and pharmaceuticals. This Special Issue will showcase the most recent advances and highly interdisciplinary approaches covering both material engineering and detection aspects of nanoimmunosensors with the goal of highlighting their widening applications in different fields, presenting challenges to their use, and exploring future research directions.
Prof. Dr. Magnus Willander
Dr. Razium Ali Soomro
Prof. Dr. Sunil Bhand
Guest Editors
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Keywords
- Immunosensor
- Nanoelectrochemical sensors
- Bio-active sensors
- Photoimmunosensors
- Photoelectrochemical immunoassay
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