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Biomedical Applications of Optical Sensing Technology

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biosensors".

Deadline for manuscript submissions: 20 August 2025 | Viewed by 449

Special Issue Editors


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Guest Editor
Department of Mathematical and Physical Sciences, Miami University Regionals, Middletown, OH 45042, USA
Interests: nanomaterials; optical properties of solids
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Engineering Technology, Miami University, Middletown, OH 45042, USA
Interests: sensor data modeling and prediction; wearable haptics; robotics; tissue biomarkers

Special Issue Information

Dear Colleagues,

Optical sensors are rapidly transforming the field of biomedical applications, including minimally invasive surgery, disease monitoring, and cell characterization, by providing critical information about tissue biomechanics, physiological fluids, and molecular changes using direct spectroscopy or reagents that interact with biological media.  

Optical sensing is promising for addressing challenges such as tissue deformations and the undesired deflection of incision tools, which can compromise the precision and safety of invasive procedures. Fluorescence-based detection and optical/acoustic imaging techniques are emerging as powerful solutions for the real-time tracking of surgical tools and enhancing visibility in complex tissue environments.

This technology also has a potential use in the monitoring of critical diseases, from cancer to autoimmune disorders, by detecting molecular affinities and mutations in various biofluids. This Special Issue aims to address the research gaps in existing optical technology such as its complex and expensive manufacturing; the amount of large data processing required, which increases computational costs; poor imaging resolutions; and hard-to-reach access areas.

We invite researchers to submit articles to this Special Issue on topics including, but not limited to, the following:

  1. Pure and hybrid optical techniques for tissue characterization;
  2. Fluorescence-based imaging for novel biomedical applications;
  3. The design of novel biosensors for the monitoring and early detection of diseases;
  4. Wearable biosensors and implantable systems;
  5. Plasmonic and photonic nanostructures;
  6. Biosensor materials;
  7. The detection of disease biomarkers;
  8. Data-driven optical biosensing with machine learning;
  9. The predictive modeling of sensor data;
  10. Non-invasive optical sensors for cell characterization;
  11. Addressing gaps in optical technology such as:
  • Sensitivity;
  • Specificity;
  • Real-time and cost-effective computational capabilities.

Dr. Mithun Bhowmick
Dr. Meenakshi Narayan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • optical sensing
  • minimally invasive surgery
  • hybrid imaging
  • tissue biomechanics
  • real time bioimaging
  • wearable biosensors
  • machine learning in biomedical applications
  • sensor data modeling
  • image processing

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Published Papers (1 paper)

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Research

15 pages, 3415 KiB  
Article
Na-Ag Ion-Exchanged Glass Substrates for Plasmon-Enhanced Fluorescence Imaging of Neutrophils
by Vladimir A. Inozemtsev, Maxim E. Dokukin, Yevgeniy M. Sgibnev, Ekaterina A. Sherstyukova, Snezhanna S. Kandrashina, Mikhail A. Shvedov, Artem V. Shelaev, Nikolay V. Nikonorov, Viktoria A. Sergunova and Alexander V. Baryshev
Sensors 2025, 25(7), 2278; https://doi.org/10.3390/s25072278 - 3 Apr 2025
Viewed by 177
Abstract
Here, we study the fluorescence response of neutrophils stained with the wheat germ agglutinin Alexa Fluor 594 dye when the cells are placed on plasmonic nanoparticle substrates. Specifically, we focused on gold and silver nanoparticles with particle sizes ranging from 12 to 250 [...] Read more.
Here, we study the fluorescence response of neutrophils stained with the wheat germ agglutinin Alexa Fluor 594 dye when the cells are placed on plasmonic nanoparticle substrates. Specifically, we focused on gold and silver nanoparticles with particle sizes ranging from 12 to 250 nm. It was demonstrated that the intensity of fluorescence can be increased by more than 10 times when using substrates with silver nanoparticles formed by Na+-Ag+ ion exchange in glass. The fluorescence enhancement depends significantly on both the size and surface density of the silver nanoparticles and the membrane staining procedure. Full article
(This article belongs to the Special Issue Biomedical Applications of Optical Sensing Technology)
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