Symmetries/Asymmetries in Neurorehabilitation

A special issue of Symmetry (ISSN 2073-8994). This special issue belongs to the section "Life Sciences".

Deadline for manuscript submissions: closed (1 February 2026) | Viewed by 719

Special Issue Editor


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Guest Editor
Department of Fundamental, Preventive, and Clinical Disciplines, Faculty of Medicine, Transilvania University of Brasov, 500036 Brasov, Romania
Interests: motion analysis; kinematics; comparative biomechanics

Special Issue Information

Dear Colleagues,

This issue will explore the critical role of symmetry and asymmetry in assessing and treating neurorehabilitation patients, particularly those with central motor neuron diseases such as Multiple Sclerosis, Spinal Cord Injuries, and Stroke, which often present similar clinical manifestations and impairments. Key topics will include the impact of motor and sensory symmetries/asymmetries on rehabilitation outcomes, advanced diagnostic techniques for identifying symmetries/asymmetries, and the development of personalized therapeutic interventions targeting asymmetrical impairments. This Special Issue will also cover the use of advanced technologies, including robotics, exoskeletons, functional electrical stimulation, repetitive transcranial magnetic stimulation (rTMS), and virtual reality, to enhance the symmetry of patient rehabilitation. This Special Issue aims to bring together cutting-edge research and clinical practices that address the challenges and opportunities of symmetry and asymmetry in neurorehabilitation, ultimately improving patient outcomes.

Dr. Nadinne Roman
Guest Editor

Manuscript Submission Information

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Keywords

  • neurorehabilitation
  • symmetry
  • asymmetry
  • central motor neuron diseases
  • multiple sclerosis
  • spinal cord injuries
  • stroke
  • advanced technologies
  • robotics
  • exoskeletons
  • functional electrical stimulation
  • repetitive transcranial magnetic stimulation (rTMS)
  • virtual reality
  • motor and sensory impairments
  • personalized therapeutic interventions

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Published Papers (1 paper)

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Review

25 pages, 567 KB  
Review
Parkinson’s Disease as a Disorder of Spatial–Temporal Symmetry
by Miso S. Park and Horyong Yoo
Symmetry 2026, 18(5), 820; https://doi.org/10.3390/sym18050820 (registering DOI) - 9 May 2026
Viewed by 171
Abstract
Parkinson’s disease (PD) is traditionally defined by dopaminergic loss in the substantia nigra, yet its heterogeneous phenotypes and prodromal trajectories challenge a linear, dopamine-centered model. The α-synuclein origin and connectome (SOC) model proposes two major trajectories: a brain-first pathway, with the pathology initiating [...] Read more.
Parkinson’s disease (PD) is traditionally defined by dopaminergic loss in the substantia nigra, yet its heterogeneous phenotypes and prodromal trajectories challenge a linear, dopamine-centered model. The α-synuclein origin and connectome (SOC) model proposes two major trajectories: a brain-first pathway, with the pathology initiating in limbic and brainstem structures and spreading ipsilaterally to the nigrostriatal system, and a body-first pathway, with the pathology originating in enteric and peripheral autonomic nerves before ascending to the brain. In this review, we integrate the SOC model into a broader framework, reconceptualizing PD as a progressive disorder of spatial–temporal symmetry. Spatial symmetry encompasses left–right and cranio-caudal balance of neural and musculoskeletal systems, whereas temporal symmetry denotes the coherence of biological rhythms from circadian and autonomic cycles, coupled with metabolic health and mitochondrial function, to sub-second timing governed by dopaminergic and basal ganglia–cortical network dynamics. We outline how systemic insulin resistance and mitochondrial stress erode temporal symmetry, while cranio-cervical malalignment and temporomandibular disorders perturb spatial symmetry. We discuss the neurobiological implementation of these symmetry axes via large-scale networks and dopaminergic modulation of spatial–temporal sensorimotor dynamics, framing PD as a multiscale symmetry-breaking process, and explore the implications for symmetry-oriented biomarkers, subtyping, and future interventions. Full article
(This article belongs to the Special Issue Symmetries/Asymmetries in Neurorehabilitation)
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