Radiation Pathology—Its Fact and Theory
A special issue of Toxics (ISSN 2305-6304).
Deadline for manuscript submissions: closed (1 May 2016)
Special Issue Editor
Interests: radiation pathology; molecuar pathology; human pathology; Fukushima nuclear plant accident; radiation biology; cancer biology; radioresistance; radiation exposure; nuclear accident/disaster; ecosystem
Special Issue Information
Dear Colleagues,
A large quantity of artificial radioactive substances were scattered by the Fukushima Daiichi Nuclear Power Plant (FNPP) incident caused by the East Japan Great Earthquake disaster. The leak of contaminated water from the FNPP has not yet ended. Ionizing radiation causes biological effects in completely opposite directions, the deterministic effect (tissue reaction) by cell death and the stochastic effect by genetic mutation. Molecular mechanisms to determine which way to go, deterministic or stochastic, remain to be elucidated. The influence of radiation cascades and propagates from physical changes to biological changes through biochemical changes. Even in the case of acute effects, the biological effects of radiation are characterized by an incubation period and need to be clarified. One of the major concerns of the effect of radiation is carcinogenesis. Considering carcinogenesis by radiation now needs a paradigm shift, such as its contribution to promotion, as well as initiation, and non-targeting effects. After the FNPP incident, radiation biology is more and more requested to answer the effects of radiation on human beings, now and in the future. Theoretical and mathematical models are also needed to connect acute effects and late effects. I believe it is timely to publish a Special Issue on “Radiation Pathology—Its Fact and Theory”.
Prof. Dr. Manabu Fukumoto, M.D.
Guest Editor
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Keywords
- radiation biology
- radiation effects
- radiation pathology
- nuclear disaster
- radiation carcinogenesis
- dose
- dose rate
- risk
- mechanisms
- epidemiology stem cells
- radionuclides
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