Toxins in Neurodegenerative Diseases: The Cause and the Cure

A special issue of Toxins (ISSN 2072-6651).

Deadline for manuscript submissions: closed (20 September 2023) | Viewed by 4118

Special Issue Editor


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Guest Editor
Laboratório Multidisciplinar de Pesquisa, Universidade São Francisco, Av. São Francisco de Assis 218, Bragança Paulista 12916-900, SP, Brazil
Interests: neurodegenerative diseases; toxins; drug discovery

Special Issue Information

Dear Colleagues,

Neurodegenerative diseases are frequent in the elderly, and due to the increase in life expectancy, the number of cases has grown significantly in recent years. Alzheimer’s disease, the main type of dementia, affected 46.8 million people in 2015, being the 7th cause of death in the world. Few specific pharmacological treatments are available so far, and other options only increase life expectancy. Aiming at an effective treatment, studies are needed for a better understanding of the disease mechanisms to further develop pharmacological therapies. In this context, venoms and secretions, which contain a wide ‘chemical library’, can provide toxins useful as tools for these studies and new treatments.

This Special Issue is focused on the use of venoms and toxins (obtained from animals, plants, microorganisms, etc.) to understand the mechanism of neurodegenerative diseases, to identify new molecular/pharmacological targets, and to share new compounds to treat these uncurable diseases. Original experimental or in silico research, short communications, and review articles are welcome.

Prof. Dr. Juliana Mozer Sciani
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • venom
  • toxin
  • neurodegenerative diseases
  • dementia
  • new molecules
  • mechanism of the disease
  • treatment

Published Papers (1 paper)

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Review

23 pages, 3841 KiB  
Review
Differential Role of Active Compounds in Mitophagy and Related Neurodegenerative Diseases
by Mark Makarov and Eduard Korkotian
Toxins 2023, 15(3), 202; https://doi.org/10.3390/toxins15030202 - 6 Mar 2023
Cited by 6 | Viewed by 3468
Abstract
Neurodegenerative diseases, such as Alzheimer’s disease or Parkinson’s disease, significantly reduce the quality of life of patients and eventually result in complete maladjustment. Disruption of the synapses leads to a deterioration in the communication of nerve cells and decreased plasticity, which is associated [...] Read more.
Neurodegenerative diseases, such as Alzheimer’s disease or Parkinson’s disease, significantly reduce the quality of life of patients and eventually result in complete maladjustment. Disruption of the synapses leads to a deterioration in the communication of nerve cells and decreased plasticity, which is associated with a loss of cognitive functions and neurodegeneration. Maintaining proper synaptic activity depends on the qualitative composition of mitochondria, because synaptic processes require sufficient energy supply and fine calcium regulation. The maintenance of the qualitative composition of mitochondria occurs due to mitophagy. The regulation of mitophagy is usually based on several internal mechanisms, as well as on signals and substances coming from outside the cell. These substances may directly or indirectly enhance or weaken mitophagy. In this review, we have considered the role of some compounds in process of mitophagy and neurodegeneration. Some of them have a beneficial effect on the functions of mitochondria and enhance mitophagy, showing promise as novel drugs for the treatment of neurodegenerative pathologies, while others contribute to a decrease in mitophagy. Full article
(This article belongs to the Special Issue Toxins in Neurodegenerative Diseases: The Cause and the Cure)
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