The Endothelial Effects of Uremic Toxins
A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Uremic Toxins".
Deadline for manuscript submissions: closed (31 August 2019) | Viewed by 37353
Special Issue Editors
Interests: uremic toxins; aryl hydrocarbon receptor; endothelium
Interests: clinical study about uremic toxins-related disease; basic study about uremic toxins-related functional abnormalities of macrophages
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear colleagues,
The number of patients who have chronic kidney disease (CKD) has increased around the world. There are many therapeutic options and clinical guidelines for kidney disease; however, clinical outcomes of CKD patients, especially those undergoing dialysis treatment, are still poor owing to various CKD-related systemic diseases. For example, the incidence of cardiovascular events increases with the progression of CKD, and lipid lowering therapy has not shown a significant effect on dialysis patients. Thus, it is thought that there are several CKD-specific risk factors for CKD-related systemic disease in addition to traditional factors.
Uremic toxins are solutes retained in CKD patients and associated with various uremic syndromes. Recent clinical and basic studies suggest that various kinds of uremic toxins are associated with CKD-related systemic disease. Of course, uremic toxins induce acceleration of atherosclerosis and vascular calcification as well as clinical cardiovascular events. The functional abnormalities of endothelial cells are critical for pathogenesis not only in cardiovascular disease but also in other general systemic diseases, and uremic toxins are associated with them.
This Special Issue entitled ‘The Endothelial Effects of Uremic Toxins’ focuses on understanding the roles of uremic toxins in endothelial dysfunctions which lead to various CKD-related systemic diseases. Papers that assess any kinds of uremic toxins and endothelial functions in basic studies and evaluate the role of toxins with several biomarkers or clinical outcomes that are related with endothelial effects in clinical studies are welcome.
Prof. Dr. Stéphane Burtey
Prof. Dr. Suguru Yamamoto
Guest Editors
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Keywords
- uremic toxins
- endothelial cells
- atherosclerosis
- vascular calcification
- indoxyl sulfate
- p-cresyl sulfate
- chronic kidney disease
- dialysis
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