Mycotoxins: Producing Fungi and Mechanisms of Phytotoxicity

A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Mycotoxins".

Deadline for manuscript submissions: closed (30 September 2019) | Viewed by 8699

Special Issue Editors


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Guest Editor
Institute for Botany, Leibniz University Hannover, Herrenhäuser Strasse 2, D-30419 Hannover, Germany
Interests: botany; abiotic stress of plants; sulfur metabolism; secondary metabolites; innovative teaching tools
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Guest Editor
Department of Botany and Microbiology, Faculty of Science, Zagazig University, Zagazig 44519, Egypt
Interests: mycotoxins; fungi; phytotoxicity; toxicity; fermentation; secondary metabolites

Special Issue Information

Dear Colleagues,

Mycotoxins are secondary metabolites of low molecular weight that are toxic to humans, animals and plants. The genera of mycotoxigenic fungi are mainly represented by Aspergillus, Penicillium and Fusarium. All of these fungi can grow on specific crops under favorable conditions of temperature and humidity, and generate mycotoxins before, during, and after harvesting, handling, and shipment. The fungal species Alternaria, Trichoderma, and Trichothecium are also important as food contaminants or pathogens for plants, among others. The extent of mycotoxin contamination of commodities is stimulated by certain environmental conditions; this differs based on geographic location, agricultural methods and the susceptibility of commodities to the penetration of fungi during storage and processing periods. Dangerous mycotoxins like aflatoxins, citrinin, patulin, penicillic acid, tenuazonic acid, beauvericin, ochratoxin A, cytochalasins, deoxynivalenol, fumonisins, fusarin C, fusaric acid, moniliformin, trichothecenes and zearalenone possess a variety of biological activities and cause morphological, physiological and metabolic effects on plants.

The primary effects of different classes of mycotoxins on plants include the seed quality, germination, viability and seedling vigour, growth of root and shoot. Moreover, the most severe dangerous effects arise from their accumulation in the plant tissues, which is consequently associated with development of plant disease symptoms. Mycotoxins (like aflatoxin, ochratoxin, and patulin) can be transported from the soil to the plant. Translocation occurs from the roots to the stems, leaves and fruits and this explains the contamination of healthy intact seeds and fruits with mycotoxins. Overall, this could be hazardous to the plant’s growth and development as well as to the consumer’s health

The focus of this Special Issue of Toxins is on mycotoxins with phytotoxic properties indicating their modes of action at the cellular, biochemical and molecular level. Knowledge can be used to develop strategies that could control pre- and post-harvest mycotoxin contamination in crops.

Prof. Dr. Jutta Papenbrock
Prof. Dr. Ahmed A. Ismaiel
Guest Editors

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Keywords

  • mycotoxins
  • phytopathogenic fungi
  • phytotoxicity
  • mycotoxin-producing fungi
  • physiological and metabolic effects
  • pre-harvest
  • post-harvest
  • management strategies

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Published Papers (2 papers)

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Research

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13 pages, 2127 KiB  
Article
Calm Before the Storm: A Glimpse into the Secondary Metabolism of Aspergillus welwitschiae, the Etiologic Agent of the Sisal Bole Rot
by Gabriel Quintanilha-Peixoto, Rosimére Oliveira Torres, Isabella Mary Alves Reis, Thiago Alves Santos de Oliveira, Dener Eduardo Bortolini, Elizabeth Amélia Alves Duarte, Vasco Ariston de Carvalho Azevedo, Bertram Brenig, Eric Roberto Guimarães Rocha Aguiar, Ana Cristina Fermino Soares, Aristóteles Góes-Neto and Alexsandro Branco
Toxins 2019, 11(11), 631; https://doi.org/10.3390/toxins11110631 - 30 Oct 2019
Cited by 10 | Viewed by 3501
Abstract
Aspergillus welwitschiae is a species of the Nigri section of the genus Aspergillus. In nature, it is usually a saprotroph, decomposing plant material. However, it causes the bole rot disease of Agave sisalana (sisal), a plant species used for the extraction of [...] Read more.
Aspergillus welwitschiae is a species of the Nigri section of the genus Aspergillus. In nature, it is usually a saprotroph, decomposing plant material. However, it causes the bole rot disease of Agave sisalana (sisal), a plant species used for the extraction of hard natural fibers, causing great economic loss to this culture. In this study, we isolated and sequenced one genome of A. welwitschiae (isolate CCMB 674 (Collection of Cultures of Microorganisms of Bahia)) from the stem tissues of sisal and performed in silico and wet lab experimental strategies to describe its ability to produce mycotoxins. CCMB 674 possesses 64 secondary metabolite gene clusters (SMGCs) and, under normal conditions, it produces secondary metabolism compounds that could disturb the cellular cycle of sisal or induce abnormalities in plant growth, such as malformin C. This isolate also produces a pigment that might explain the characteristic red color of the affected tissues. Additionally, this isolate is defective for the production of fumonisin B1, and, despite bearing the full cluster for the synthesis of this compound, it did not produce ochratoxin A. Altogether, these results provide new information on possible strategies used by the fungi during the sisal bole rot, helping to better understand this disease and how to control it. Full article
(This article belongs to the Special Issue Mycotoxins: Producing Fungi and Mechanisms of Phytotoxicity)
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Review

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14 pages, 1222 KiB  
Review
Phytotoxic Metabolites Produced by Legume-Associated Ascochyta and Its Related Genera in the Dothideomycetes
by Wonyong Kim and Weidong Chen
Toxins 2019, 11(11), 627; https://doi.org/10.3390/toxins11110627 - 29 Oct 2019
Cited by 19 | Viewed by 4649
Abstract
Phytotoxins, secondary metabolites toxic to plants and produced by fungi, are believed to play an important role in disease development by targeting host cellular machineries and/or interfering with host immune responses. The Ascochyta blight diseases on different legume plants are caused by Ascochyta [...] Read more.
Phytotoxins, secondary metabolites toxic to plants and produced by fungi, are believed to play an important role in disease development by targeting host cellular machineries and/or interfering with host immune responses. The Ascochyta blight diseases on different legume plants are caused by Ascochyta and related taxa, such as Phoma. The causal agents of the Ascochyta blight are often associated with specific legume plants, showing a relatively narrow host range. The legume-associated Ascochyta and Phoma are known to produce a diverse array of polyketide-derived secondary metabolites, many of which exhibited significant phytotoxicity and have been claimed as virulence or pathogenicity factors. In this article, we reviewed the current state of knowledge on the diversity and biological activities of the phytotoxic compounds produced by Ascochyta and Phoma species. Also, we touched on the secondary metabolite biosynthesis gene clusters identified thus far and discussed the role of metabolites in the fungal biology. Full article
(This article belongs to the Special Issue Mycotoxins: Producing Fungi and Mechanisms of Phytotoxicity)
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