Resistance to Staphylococcus aureus Toxins
A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Bacterial Toxins".
Deadline for manuscript submissions: closed (30 June 2021) | Viewed by 32310
Special Issue Editor
Interests: chronic infections; diabetic foot ulcers; recurrent urinary tract infections; microbiota; virulence; resistance; diagnostic tool; alternative treatments
Special Issue Information
Dear Colleagues,
Staphylococcus aureus is a commensal microorganism that is often present asymptomatically on parts of the human body. S. aureus is also a major human pathogen able to adapt to diverse hosts and environmental conditions, and to cause diverse infections (e.g., bloodstream infections, endocarditis, skin and soft tissue infections, osteomyelitis, lower respiratory tract). S. aureus is equipped with a collection of virulence factors and toxins, often making it responsible for many toxin-mediated diseases.
A WHO report on ‘Antimicrobial resistance: global report on surveillance’ highlights that the methicillin-resistant S. aureus (MRSA) strains remain a public health problem and a threat to humans associated with high morbidity, mortality, and socioeconomic costs. Antibiotic resistance is a global crisis, which urgently requires alternative strategies to standard antibiotic therapy. MRSA was associated with healthcare settings, the so-called hospital-associated MRSA (HA-MRSA). More recently, community-acquired MRSA (CA-MRSA) infections have been rising in frequency, and now MRSA strains also represent a major cause of community-associated infections. CA-MRSA is genetically distinct from HA-MRSA, being resistant to fewer antibiotics, carrying a smaller trait of SCCmec, and often producing the Panton–Valentine leukocidin. Moreover, CA-MRSA invading healthcare settings has been also identified as the etiological agent of nosocomial outbreaks.
This Special Issue aims to characterize and discuss the pathogenesis of S. aureus infection; the epidemiology of virulence content of MRSA; the physiopathology and clinical aspects of the virulence (notably the toxinogenic markers) in MRSA; the evolution of resistance and virulence determinants during the infections; the genetic adaptation of S. aureus to antibiotics and its environment; and the in vitro, ex vivo, and in vivo impacts of antibiotics or alternative strategies on S. aureus virulence. Discussions can be proposed in the light to limit antibiotic used and discover new alternative therapeutic solutions to fight against S. aureus virulence and reduce antibiotic resistance.
Prof. Dr. Jean-Philippe Lavigne
Guest Editor
Manuscript Submission Information
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Keywords
- S. aureus
- MRSA
- Pathogenesis
- Genetic adaptation
- Antibiotic resistance
- Virulence
