Leishmaniasis Treatment: Current Situation and Future Perspectives

A special issue of Tropical Medicine and Infectious Disease (ISSN 2414-6366). This special issue belongs to the section "Neglected and Emerging Tropical Diseases".

Deadline for manuscript submissions: closed (30 May 2023) | Viewed by 2862

Special Issue Editors


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Guest Editor
Gonçalo Moniz Institute (IGM), Oswaldo Cruz Foundation (FIOCRUZ/BA), Salvador 40296-710, Brazil
Interests: innate immunity; microRNAs; diabetes; leishmaniasis; host–pathogen interaction

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Guest Editor
Department of Cell Biology, Institute of Biological Sciences, University of Brasília, Brasília 70910-900, Brazil
Interests: innate immunity; human leishmaniasis; canine leishmaniasis

Special Issue Information

Dear Colleagues,

Tropical Medicine and Infectious Diseases is pleased to annouce a Special Issue on “Leishmaniasis Treatment: Current Situation and Future Perspectives”, which will publish relevant studies reporting the current situation and future perspectives of leishmaniasis treatment through research that ranges from basic to translational.

Leishmaniasis is a complex of neglected tropical diseases that affects more than one billion people living in endemic areas. It is a vector-borne disease caused by protozoan parasites of the genus Leishmania, which comprises more than 20 species. Leishmaniasis is associated with three main clinical manifestations, including cutaneous, visceral and mucosal, each with a particular response to treatment.

Currently, the control of leishmaniasis relies on treatment with only three first-line therapies, and drug resistance limits their efficacy. This is one of the major challenges for the successful response to treatment and a patient’s full recovery. These limitations highlight the importance of developing new and innovative therapeutic strategies to efficiently control the disease.

Therefore, we welcome research groups and public health experts to submit their recent findings, either in the form of original research or a review focusing on different aspects of Leishmania research, such as: the current situation of treatment for leishmaniasis and recent advances in drug development (all clinical manifestations included); new and innovative strategies to treat leishmaniasis; therapy combinations; novel markers of prognosis and the response to treatment in leishmaniasis; mechanisms of drug resistance to leishmaniasis; immunotherapy; mechanisms of alternative drug-delivery systems and drug action to treat leishmaniasis; and future perspectives in leishmanisis treatment.

Dr. Natalia Machado Tavares
Dr. Cecília Beatriz Fiuza Favali
Guest Editors

Manuscript Submission Information

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Keywords

  • leishmaniasis
  • treatment
  • therapy
  • Leishmania
  • drug development
  • tropical disease

Published Papers (1 paper)

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Review

14 pages, 1546 KiB  
Review
Alternative Non-Drug Treatment Options of the Most Neglected Parasitic Disease Cutaneous Leishmaniasis: A Narrative Review
by Mohamed A. A. Orabi, Ahmed A. Lahiq, Ahmed Abdullah Al Awadh, Mohammed Merae Alshahrani, Basel A. Abdel-Wahab and El-Shaymaa Abdel-Sattar
Trop. Med. Infect. Dis. 2023, 8(5), 275; https://doi.org/10.3390/tropicalmed8050275 - 14 May 2023
Viewed by 2423
Abstract
With more than 12 million cases worldwide, leishmaniasis is one of the top 10 neglected tropical diseases. According to the WHO, there are approximately 2 million new cases each year in foci in around 90 countries, of which 1.5 million are cutaneous leishmaniasis [...] Read more.
With more than 12 million cases worldwide, leishmaniasis is one of the top 10 neglected tropical diseases. According to the WHO, there are approximately 2 million new cases each year in foci in around 90 countries, of which 1.5 million are cutaneous leishmaniasis (CL). Cutaneous leishmaniasis (CL) is a complex cutaneous condition that is caused by a variety of Leishmania species, including L. (Leishmania) major, L. (L) tropica, L. (L) aethiopica, L. (L) mexicana, L. (Viannia) braziliensis, and L. (L) amazonensis. The disease imposes a significant burden on those who are affected since it typically results in disfiguring scars and extreme social stigma. There are no vaccines or preventive treatments available, and chemotherapeutic medications, including antimonials, amphotericin B, miltefosine, paromomycin, pentamidine, and antifungal medications, have a high price tag, a significant risk of developing drug resistance, and a variety of systemic toxicities. To work around these limitations, researchers are continuously looking for brand-new medications and other forms of therapy. To avoid toxicity with systemic medication use, high cure rates have been observed using local therapy techniques such as cryotherapy, photodynamic therapy, and thermotherapy, in addition to some forms of traditional therapies, including leech and cauterization therapies. These CL therapeutic strategies are emphasized and assessed in this review to help with the process of locating the appropriate species-specific medicines with fewer side effects, lower costs, and elevated cure rates. Full article
(This article belongs to the Special Issue Leishmaniasis Treatment: Current Situation and Future Perspectives)
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