Omics Technologies Applied to Tuberculosis Research
A special issue of Tropical Medicine and Infectious Disease (ISSN 2414-6366). This special issue belongs to the section "Infectious Diseases".
Deadline for manuscript submissions: closed (19 February 2022) | Viewed by 8005
Special Issue Editor
Interests: tuberculosis; transcription; translation; ribosome; omics; stress adaptation; selective translation; pathogenesis; bacteria; gene expression; antimicrobial resistance
Special Issue Information
Dear Colleagues,
Mycobacterium tuberculosis is the causative agent of human tuberculosis, one of the deadliest diseases experienced by humans. Tuberculosis remains a threat to the health of people worldwide, with 10 million new cases and 1.2 million deaths caused by this disease in 2019. It is estimated that one-quarter of the world’s population harbours Mycobacterium tuberculosis but has an asymptomatic infection referred to as latent tuberculosis. This reflects the complex life cycle of the bacteria that can involve prolonged periods of persistent non-replication prior to initiation of the active disease process that is required for onward transmission. The immunology of tuberculosis is complex and multifaceted, and even today, immunological parameters or biomarkers that predict who will control the infection and who will develop clinical disease have not been identified. Equally, the molecular basis of bacterial adaptation within the host is poorly understood. Thus, to combat the rise of M. tuberculosis multidrug-resistant strains, a system-level understanding of this disease is imperative.
The advent of high-throughput platforms has allowed integrated study of biological systems and has revolutionised biomedical research through characterising molecular mechanisms associated with pathogenicity and disease and deciphering the evolutionary history of important pathogens. In this Special Issue, we aim to highlight how the application of omics technologies is shaping our understanding of M. tuberculosis, the evolution of tuberculosis, and host–pathogen interactions. We will also cover how omics technologies have contributed to the fight against antimicrobial resistance and informed drug discovery pipelines.
Dr. Teresa Cortes
Guest Editor
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Keywords
- omics
- tuberculosis
- Mycobacterium tuberculosis
- pathogen biology
- host–pathogen interactions
- epidemiology
- drug discovery
- antimicrobial resistance
- evolution
- omics for tuberculosis drug discovery
- biomarkers and blood signatures
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