Recent Research on Human Papillomavirus (HPV) Infection and Vaccination: 2nd Edition

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Human Papillomavirus Vaccines".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 1172

Special Issue Editors


E-Mail Website
Guest Editor
Laboratory of Immunogenetics, Institute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical College, Kunming 650118, China
Interests: immunogenetic basis of susceptibility and resistance to human papilloma virus infection; the application of immunogenetics in novel vaccine design, development and evaluation, such as HPV therapeutic vaccine
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Yunnan Key Laboratory of Vaccine Research & Development on Severe Infectious Disease, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650118, China
Interests: host-HPV in the development of cervical cancer and the HPV therapeutic vaccine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We invite you to contribute an article for the Special Issue on “Recent Research on Human Papillomavirus (HPV) Infection and Vaccination: 2nd Edition”. Persistent infection with human papillomavirus is associated with nearly all cervical cancers and a significant proportion of anogenital and oropharyngeal cancers. In recent years, considerable progress has been made in cervical cancer prevention, particularly regarding the availability of prophylactic vaccines. However, the HPV vaccine has not yet achieved widespread coverage, and vaccination rates have decreased during the COVID-19 pandemic. It is crucial to enhance HPV vaccine education, vaccination efforts, and early prevention, especially in low-income countries, where dissemination and acceptance of the vaccine face multiple challenges. Moreover, it is important to explore various mechanisms of HPV-associated malignancies, host immune system responses to HPV, and the impact of HPV vaccination.

We welcome original research articles and reviews for this Special Issue. Potential areas of investigation include vaccination implementation strategies, effective tools or interventions to improve public awareness of HPV vaccination, host factors related to HPV infection, HPV persistence and cancer, co-infection with other pathogens, interactions between HPV and the host immune system, and HPV vaccine development.

Prof. Dr. Li Shi
Prof. Dr. Yufeng Yao
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • HPV infection
  • HPV vaccination
  • willingness
  • hesitancy
  • therapeutic vaccines
  • cervical cancer prevention

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Related Special Issue

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Other

12 pages, 826 KB  
Brief Report
Disrupted Vaginal Microbiota and Increased HPV Infection Risk Among Non-Vaccinated Women: Findings from a Prospective Cohort Study in Kazakhstan
by Kuralay Kongrtay, Kuat Kassymbek, Gulzhanat Aimagambetova, Nazira Kamzayeva, Sanimkul Makhambetova, Makhabbat Galym, Zhanar Abdiyeva, Milan Terzic, Kadisha Nurgaliyeva and Talshyn Ukybassova
Vaccines 2025, 13(7), 679; https://doi.org/10.3390/vaccines13070679 - 25 Jun 2025
Viewed by 947
Abstract
Introduction: Vaginal microbiota has emerged as an important factor influencing human papillomavirus (HPV) persistence and host immunity. While HPV infection is often transient, persistent infections with high-risk HPV genotypes significantly increase the risk of cervical carcinogenesis. Thus, this study aims to investigate [...] Read more.
Introduction: Vaginal microbiota has emerged as an important factor influencing human papillomavirus (HPV) persistence and host immunity. While HPV infection is often transient, persistent infections with high-risk HPV genotypes significantly increase the risk of cervical carcinogenesis. Thus, this study aims to investigate the association between microflora/sexually transmitted infections (STIs) and HPV infection, with a focus on the prevalence of coinfection and the potential role of genital tract microecological disorders. Methods: A prospective cohort study was conducted at a tertiary care center in Astana, Kazakhstan, between November 2024 and March 2025. A total of 396 non-pregnant women aged 18–45 years were enrolled during routine gynecological screening. Cervical samples were collected for high-risk HPV genotyping and the detection of 11 other vaginal microorganisms using real-time PCR. Results: HPV-positive women were significantly younger and more likely to be single compared to HPV-negative participants. They also had fewer pregnancies and deliveries and were more likely to use barrier contraception. Among STIs, Mycoplasma hominis demonstrated a significant association with HPV infection (adjusted OR = 2.16, 95% CI: 1.15–4.05, p = 0.017). Overall STI presence (adjusted OR = 2.16, p = 0.017) and STI multiplicity (adjusted OR = 1.36 per additional STI, p = 0.017) were also significantly associated with HPV positivity. Correlation analysis revealed a moderate association between Chlamydia trachomatis and Trichomonas vaginalis (ϕ = 0.39, p < 0.001), suggesting shared ecological or transmission pathways. Conclusion: The findings highlight the relevance of specific vaginal pathogens, particularly Mycoplasma hominis, and co-infection patterns in increasing the risk of HPV infection. These results underscore the importance of comprehensive STI screening and microbial profiling in cervical cancer prevention strategies, especially in populations with limited access to HPV vaccination. Further longitudinal and mechanistic studies are warranted to elucidate causal pathways and progression to cervical neoplasia. Full article
Show Figures

Figure 1

Back to TopTop