The Role of Mucosal Immune System in Intestinal Inflammatory Disorders
A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Clinical Immunology".
Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 257
Special Issue Editors
Interests: chronic inflammation; immune-mediated diseases; pathogenic T cell responses
Interests: inflammatory bowel disease; perianal disease; patient stratification; personalized medicine
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The intestines are one of our largest barrier tissues. They are in contact with a large number of pathogenic and commensal microorganisms, as well as antigens present in food components. Intestinal inflammation can arise due to interaction of the immune system with pathogens, but can also be caused by changes in our commensal flora, exposure to chemicals, and dietary changes. Inflammation is usually rapidly resolved but in some cases, a dysregulated immune response arises and leads to chronic inflammation, such as that found in inflammatory bowel disease. Multiple factors contribute to this dysregulated response, including genetic predisposition, altered microbiota, and environmental factors. This complexity is reflected in patient heterogeneity. Identifying the individual factors that contribute to pathology on a patient level would help tailor treatment more effectively.
This Special Issue aims to unravel different pathogenic immune cell subsets and mediators that contribute to chronic intestinal inflammation, as well as novel and tailored treatment strategies. Original research articles and reviews are welcome. Research areas may include the following: analysis of inflammation-associated cellular and molecular mediators in patients with chronic inflammation or in mouse models; biomarker studies in serum from patients and novel strategies to identify resistance/susceptibility to treatment and predict relapse-free remission.
We look forward to receiving your contributions.
Dr. Maria Fernanda Pascutti
Dr. Andrea van der Meulen
Guest Editors
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Keywords
- chronic inflammation
- gut, microbiota
- inflammatory bowel disease
- biomarkers
- remission
- immune cell subsets
- immune mediators
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