Antibody Immunity against Emerging Pathogens

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Pathogens-host Immune Interface".

Deadline for manuscript submissions: 31 January 2025 | Viewed by 756

Special Issue Editors


E-Mail Website
Guest Editor
A*STAR Infectious Diseases Labs (ID Labs), Singapore, Singapore
Interests: infectious diseases; immunology; neuroimmunology; aging; autoimmunity

E-Mail Website
Guest Editor
A*STAR Infectious Diseases Labs (ID Labs), Singapore, Singapore
Interests: infectious diseases; immunology; clinical immunology

Special Issue Information

Dear Colleagues,

Emerging infections are a global health concern, and antibodies produced by the body fight invading pathogens. Antibodies have different mechanisms, can be antigen-specific, and are used to evaluate immune statuses. However, antibodies can also exacerbate disease severity and hinder vaccine development. This Special Issue aims to explore and understand the roles of antibodies in emerging and re-emerging viral infections, including profiling humoral responses, protective mechanisms, molecular mechanisms, improved strategies, therapeutic advances, and cross-reactive immunity.

The purpose of this Special Issue is to investigate and comprehend the role of antibodies in the context of emerging and re-emerging infections. The objective is to delve into the following aspects in detail:

  • Characterization of humoral responses during viral, bacterial or fungal infections.
  • Identification of new protective mechanisms of antibodies during acute and chronic infections.
  • Study of the molecular mechanisms of autoantibodies that worsen microbial infections.
  • Advancements in strategies to elicit antibody responses through vaccination.
  • Recent developments in therapeutic antibodies against microbial infections.
  • Analysis of cross-reactive immunity following infection and vaccination.

Dr. Fok Moon Lum
Dr. Siew-Wai Fong
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antibodies
  • autoantibodies
  • natural antibodies
  • autoimmunity
  • pathogenesis
  • humoral immunity
  • vaccination
  • diagnostic

Published Papers (1 paper)

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Research

11 pages, 980 KiB  
Article
Influence of Maternal and Neonatal Factors on Transplacental Passive Immunity after Vaccination against COVID-19
by Rebeca Martínez-Quezada, Omar Esteban Valencia-Ledezma, Tito Ramírez-Lozada, Carlos Emilio Miguel-Rodríguez, Juan Carlos Fernández-Hernández and Gustavo Acosta-Altamirano
Vaccines 2024, 12(8), 860; https://doi.org/10.3390/vaccines12080860 - 31 Jul 2024
Viewed by 399
Abstract
In the present study, we evaluated the influence of maternal and neonatal factors on the efficiency of the placental transfer of neutralizing antibodies against SARS-CoV-2. Vaccination during pregnancy provides fetal and neonatal protection through the passive transplacental transfer of maternal neutralizing antibodies. To [...] Read more.
In the present study, we evaluated the influence of maternal and neonatal factors on the efficiency of the placental transfer of neutralizing antibodies against SARS-CoV-2. Vaccination during pregnancy provides fetal and neonatal protection through the passive transplacental transfer of maternal neutralizing antibodies. To date, little information is available regarding the factors that affect the transfer of antibodies against SARS-CoV-2. A retrospective, cross-sectional, observational, and analytical study was carried out. It was found that several biological factors could be altering transplacental passive immunity after vaccination against COVID-19. In our study population, type 2 diabetes mellitus and chronic hypertension tended to decrease efficiency, while data from women with pre-eclampsia showed better indices compared to those from women with healthy pregnancies. Neonates born prematurely showed lower transfer rates when compared to healthy neonates. The premature rupture of membranes significantly decreased antibody transfer. Taken together, the data suggest that vaccination against COVID-19 during pregnancy is effective even under certain unfavorable clinical conditions for the mother, fetus, and neonate. It is important to create and disseminate immunization strategies in vulnerable populations to reduce maternal and perinatal morbidity and mortality associated with infections preventable by vaccination. Full article
(This article belongs to the Special Issue Antibody Immunity against Emerging Pathogens)
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