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8.9
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Journals
Vaccines
Special Issues
Role of Host Pathogen Interactions and/or Epigenetics in Vaccine Development
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Role of Host Pathogen Interactions and/or Epigenetics in Vaccine Development

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Pathogens-host Immune Interface".

Deadline for manuscript submissions: closed (31 October 2021) | Viewed by 6506

Special Issue Editors

Dr. Ravikanth Nanduri

E-Mail Website
Guest Editor
Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Interests: host-pathogen interactions; epigenetics; HMG proteins; vaccines; autophagy; nuclear receptors; autoimmunity; metabolic diseases
Dr. Bhagyaraj Ella

E-Mail Website
Guest Editor
Department of Infectious disease and Immunology, University of Florida, Gainesville, FL 32611, USA
Interests: Mucosal Immunology; Host pathogen interactions; Therapeutic vaccines; Autoimmunity and Cancer immunology
Dr. Hedwin Kitdorlang Dkhar

E-Mail Website1 Website2
Guest Editor
Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
Interests: Infectious Diseases; Infection and Immunity; Immunology; Vaccine; Host-Pathogen crosstalk; Tuberculosis; Transcriptomics

Special Issue Information

Dear Colleagues,

Globally vaccines administration saved millions of lives till now against infectious pathogens by inducing both hosts innate and acquired immunity. Enormous research efforts are being performed worldwide to improve currently used and newly developed candidate vaccine by intervening new strategies. Different types pathogens such as bacteria, viruses, fungi, protozoa and worms have evolved mechanism to escape the hostile host immune defense to cause infection. Hence, understanding host-pathogen interactions, and immune evasion mechanisms are key to improve the vaccine strategies and development. Interestingly, growing evidences suggest that vaccines and infections can alter the host epigenome and modulate immune responses. Initial evidences on alteration in DNA methylation induced by carcinogenetic viruses and bacteria highlight the interesting link between host-pathogen interactions and epigenetics. The universally administered BCG vaccine induces genome wide epigenetic reprogramming in innate immune cells which develops immune memory to confer heterologous protection against infections. This special issue of MDPI Vaccines brings together peer review articles and reviews on research that are focused on host-pathogen interactions and/ or Epigenetics in Vaccine development. We encourage submitting articles and review current efforts on vaccine development against all types of pathogens including that caused recent epidemics such as Ebola, MERS-CoV and SARS-coV-2 etc.Names

Dr. Ravikanth Nanduri
Dr. Bhagyaraj Ella
Dr. Hedwin Kitdorlang Dkhar
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Vaccine development
  • Host-pathogen interactions
  • Vaccine-Host interactions
  • Epigenetics in vaccine development
  • Vaccine induced epigenetics in host

Published Papers (1 paper)

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Research

38 pages, 1950 KiB  
Article
Pneumococcal and Influenza Vaccination Rates and Pneumococcal Invasive Disease Rates Set Geographical and Ethnic Population Susceptibility to Serious COVID-19 Cases and Deaths
by Robert Root-Bernstein
Vaccines 2021, 9(5), 474; https://doi.org/10.3390/vaccines9050474 - 8 May 2021
Cited by 15 | Viewed by 5537
Abstract
This study examines the relationship of pneumococcal vaccination rates, influenza, measles-mumps-rubella (MMR) diphtheria-tetanus-pertussis vaccinations (DTP), polio, Haemophilus influenzae type B (Hib), and Bacillus Calmette–Guerin (tuberculosis) vaccination rates to COVID-19 case and death rates for 51 nations that have high rates of COVID-19 testing [...] Read more.
This study examines the relationship of pneumococcal vaccination rates, influenza, measles-mumps-rubella (MMR) diphtheria-tetanus-pertussis vaccinations (DTP), polio, Haemophilus influenzae type B (Hib), and Bacillus Calmette–Guerin (tuberculosis) vaccination rates to COVID-19 case and death rates for 51 nations that have high rates of COVID-19 testing and for which nearly complete childhood, at-risk adult and elderly pneumococcal vaccination data were available. The study is unique in a large number of nations examined, the range of vaccine controls, in testing effects of combinations of vaccinations, and in examining the relationship of COVID-19 and vaccination rates to invasive pneumococcal disease (IPD). Analysis of Italian regions and the states of the United States were also performed. Significant positive correlations were found between IPD (but not lower respiratory infections) and COVID-19 rates, while significant negative correlations were found between pneumococcal vaccination and COVID-19 rates. Influenza and MMR vaccination rates were negatively correlated with lower respiratory infection (LRI) rates and may synergize with pneumococcal vaccination rates to protect against COVID-19. Pneumococcal and influenza vaccination rates were independent of other vaccination rates. These results suggest that endemic rates of bacterial pneumonias, for which pneumococci are a sentinel, may set regional and national susceptibility to severe COVID-19 disease and death. Full article
(This article belongs to the Special Issue Role of Host Pathogen Interactions and/or Epigenetics in Vaccine Development)
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