The Interaction of Cytomegalovirus with the Human Immune System
A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Pathogens-host Immune Interface".
Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 5103
Special Issue Editors
Interests: cytomegalovirus; T cells; immune escape; transplant; congenital infections
Special Issue Information
Dear Colleagues,
Cytomegalovirus (CMV) infection is typically asymptomatic or mild in immunologically normal hosts. CMV and the human immune system interact via numerous mechanisms that can differ by cell type and tissue context, eventually settling on a lifetime relationship that preserves survival of both virus and host. However, clinical disease can be severe in high-risk populations such as transplant recipients or fetuses during early gestation. The mechanisms of virus-immune interactions that culminate in the wide range of observed clinical outcomes in these groups are insufficiently understood. Advances in prevention and treatment strategies depend on more detailed knowledge of these mechanisms, their relative significance, and their local tissue context, particularly those leading to more severe disease or viral transmission from transplanted organ to recipient or from mother to fetus. This new knowledge can then be applied to the design of immune-based interventions that maximize protection while reducing the risk of pathologic effects.
In support of such progress, this special issue of Vaccines curates a series of impactful studies that delve into essential elements of the interaction between CMV and the human immune system. We invite you to join in sharing knowledge so that our collective wisdom continues to advance the CMV field into the future.
Dr. Laura L. Gibson
Prof. Dr. Matthew Reeves
Guest Editors
Manuscript Submission Information
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Keywords
- cytomegalovirus
- innate immunity
- adaptive immunity
- CMV vaccine
- immune interventions
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