Therapeutic Tumor Vaccine
A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Cancer Vaccines and Immunotherapy".
Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 3762
Special Issue Editor
Special Issue Information
Dear Colleagues,
Tumor vaccination combines the success story of tumor immunotherapy with the advances in precision and personalized medicine. The research field of tumor vaccination has rapidly expanded over the last decade, encompassing in vitro approaches such as T-cell transfer therapy, antigen-presenting cell-directed approaches, in situ vaccination, and the use of oncolytic viruses, all with the aim of eliciting or restoring an efficient antitumor response. However, so far, only a few therapeutic strategies have reached clinical implementation (and predominantly in hematological malignancies, not solid tumors), despite promising preclinical data and sophisticated immunological techniques. The most widely known prophylactic vaccine against an oncological disease, the HPV vaccine, has already witnessed encouraging success in clinical translation.
The main focus of this Special Issue is to critically assess current strategies in the field of vaccines, both against established tumors and in prophylactic intent, to shed light on new emerging concepts as well as to illustrate the effect of cancer vaccines on tumors, the tumor microenvironment and on systemic immunology. All strategical aspects, including the identification of tumor-associated antigenes, myeloid and lymphoid cell targeting and function, as well as delivery platforms for tumor vaccines, are of interest for this Special Issue. We also invite papers that describe the advantages and disadvantages of clinical translation of tumor vaccines.
In summary, submissions, including original research, reviews or methods papers on all aspects of tumor vaccination are very welcome. We sincerely hope that this Special Issue may serve as a platform for exchanging important developments in tumor vaccinations for human tumors and will contribute to the understanding and therapy of oncological diseases.
Dr. Isabella Lurje
Guest Editor
Manuscript Submission Information
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Keywords
- tumor vaccination
- CAR T-cell therapy
- antigen-presenting cells
- oncolytic virus
- cancer immunotherapy
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