Hepatitis and Immunity

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Hepatitis Virus Vaccines".

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 2388

Special Issue Editor


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Guest Editor
Department of Infectious Diseases, Molecular Virology, University Hospital Heidelberg, Heidelberg, Germany
Interests: hepatitis; immunity research

Special Issue Information

Dear Colleagues, 

Hepatitis is an inflammation of the liver that is caused by a variety of infectious viruses  and noninfectious agents leading to a range of health problems, some of which can be fatal. Types B and C lead to chronic disease in hundreds of millions of people and together are the most common cause of liver cirrhosis, liver cancer and viral hepatitis-related deaths. An estimated 354 million people worldwide live with hepatitis B or C, and for most, testing and treatment remain beyond reach. Some types of hepatitis are preventable through vaccination. A WHO study found that an estimated 4.5 million premature deaths could be prevented in low- and middle-income countries by 2030 through vaccination, diagnostic tests, medicines and education campaigns. WHO’s global hepatitis strategy, endorsed by all WHO Member States, aims to reduce new hepatitis infections by 90% and deaths by 65% between 2016 and 2030.

We are seeking high-quality contributions that explore the The interplay between host innate immunity and hepatitis. We are pleased to invite you to contribute to this special issue, which aims at anylising host innate immunity for the hepatitis. We welcome multidisciplinary work.

Dr. Wenshi Wang
Guest Editor

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Keywords

  • hepatitis A
  • hepatitis B
  • hepatitis C
  • hepatitis D
  • immunity research

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Published Papers (1 paper)

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Review

14 pages, 291 KiB  
Review
Innovative Therapies Targeting the Virus and the Host for Treating Chronic Hepatitis B Virus Infection: From Bench to Bedside
by Sheikh Mohammad Fazle Akbar, Mamun Al Mahtab, Sakirul Khan, Osamu Yoshida, Julio Cesar Aguilar, Guillen Nieto Gerardo and Yoichi Hiasa
Vaccines 2022, 10(5), 746; https://doi.org/10.3390/vaccines10050746 - 10 May 2022
Cited by 1 | Viewed by 2078
Abstract
Chronic hepatitis B (CHB) is a highly complicated pathological process in which the disease is initiated by the hepatitis B virus (HBV); however, host immune responses are primarily responsible for variable extents of liver damage. If the patients with CHB remain untreated, many [...] Read more.
Chronic hepatitis B (CHB) is a highly complicated pathological process in which the disease is initiated by the hepatitis B virus (HBV); however, host immune responses are primarily responsible for variable extents of liver damage. If the patients with CHB remain untreated, many CHB patients will eventually develop complications like cirrhosis of the liver (LC) and hepatocellular carcinoma (HCC). In 2019, an estimated 882,000 patients died due to HBV-related complications worldwide. Accordingly, several drugs with antiviral properties have been used to treat CHB patients during the last four decades. However, the treatment outcome is not satisfactory because viral suppression is not usually related to the containment of progressive liver damage. Although proper reconstruction of host immunity is essential in CHB patients, as of today, there is no acceptable immune therapeutic protocol for them. These realities have exposed new, novel, and innovative therapeutic regimens for the management of CHB patients. This review will update the scope and limitation of the different innovative antiviral and immune therapeutic approaches for restoring effective host immunity and containing the virus in CHB patients to block progression to LC and HCC. Full article
(This article belongs to the Special Issue Hepatitis and Immunity)
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