Human Host–Microbiota Interactions

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Clinical Immunology".

Deadline for manuscript submissions: closed (31 January 2021) | Viewed by 3868

Special Issue Editors


E-Mail Website
Guest Editor
J. Craig Venter Institute, La Jolla, CA, USA
University of California, San Diego, San Diego, CA, USA
San Diego State University, San Diego, CA, USA
Interests: fungal and bacterial genetics; pathogenesis; host–microbe interactions

E-Mail Website
Guest Editor
1. J. Craig Venter Institute, Rockville, MD, USA
2. J. Craig Venter Institute, La Jolla, CA, USA
Interests: human microbiota; host-microbe interactions

Special Issue Information

Dear Colleagues,

We are soliciting article submissions for this Special Issue of MDPI Vaccines, titled “Human Host–Microbiota Interactions”. Humans are colonized by trillions of microorganisms, including bacteria, archaea, and fungi as well as viruses. The human microbiome has been a major area of global research focus for over a decade. With thousands of research articles published to date, we now have a good understanding of the composition of the human gut, oral, and skin microbiota as well as the environmental and host genetic factors that affect microbial composition. Most of the findings have been correlative, and we still know very little about the molecular mechanisms of how microbiota interact with and manipulate the human host. In this Special Issue, we will include reviews of our current understanding of host–microbiota interactions in humans and research articles presenting new findings of the molecular details of interactions between microbiota and the human host. Future research focusing on human host–microbiota interactions will improve our understanding of the molecular mechanisms of how these interactions occur and will allow us to develop intervention strategies to manipulate microbial composition or function to improve human health.

Prof. Dr. Sinem Beyhan
Prof. Dr. Karen E. Nelson
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microbiome
  • mycobiome
  • gut microbiota
  • skin microbiota
  • oral microbiota
  • host response
  • health and disease

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

16 pages, 4395 KiB  
Article
Primary Human Dendritic Cells and Whole-Blood Based Assays to Evaluate Immuno-Modulatory Properties of Heat-Killed Commensal Bacteria
by James E. Norton, Jr., Sushma Kommineni, Patricia Akrivoulis, Dario A. Gutierrez, Daria J. Hazuda and Gokul Swaminathan
Vaccines 2021, 9(3), 225; https://doi.org/10.3390/vaccines9030225 - 5 Mar 2021
Cited by 5 | Viewed by 3390
Abstract
There is mounting evidence that the microbiome plays a critical role in training and maturation of the host immune system. Pre-clinical and clinical studies have shown that microbiome perturbation is correlated with sub-optimal host responses to vaccines and cancer immunotherapy. As such, identifying [...] Read more.
There is mounting evidence that the microbiome plays a critical role in training and maturation of the host immune system. Pre-clinical and clinical studies have shown that microbiome perturbation is correlated with sub-optimal host responses to vaccines and cancer immunotherapy. As such, identifying species of commensal bacteria capable of modulating immunological outcomes is of considerable interest. Currently, the lack of reliable primary immune cell-based assays capable of differentiating immuno-modulatory properties of various commensal bacteria is a major limitation. Here, we demonstrate that primary human monocyte-derived dendritic cells (MoDC) are capable of stratifying different strains of live and heat-killed commensal bacteria in an in vitro culture system. Specifically, heat-killed bacterial strains were able to differentially modulate co-stimulation/maturation markers CD80, CD83, and HLA-DR, as well as cytokine/chemokine signatures, such as IL-1b, MIP-1a, and TNFa in primary human MoDC. We further validated our observations using the TruCulture® (Myriad RBM, Inc., Austin, TX, USA) whole-blood ex vivo culture system. Using this ex vivo system allowed us to measure immune-altering effects of commensal bacteria in primary human whole-blood. As such, we report that both these primary in vitro and ex vivo systems are robust and enable identification, stratification, and differentiation of various commensal bacteria as potential modulators of host immunity. Full article
(This article belongs to the Special Issue Human Host–Microbiota Interactions)
Show Figures

Figure 1

Back to TopTop