Innate and Adaptive Immune Responses to Arbovirus Infections

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Viral Immunology, Vaccines, and Antivirals".

Deadline for manuscript submissions: 15 January 2025 | Viewed by 1340

Special Issue Editors


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Guest Editor
Department of Microbiology and Parasitology, Biosciences Center, Federal University of Rio Grande do Norte, Natal 59064-741, RN, Brazil
Interests: immune response against viral infections; prevalence and influence of comorbidities on the immunological response to arboviruses; immune response in congenital infections

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Guest Editor
Department of Microbiology and Parasitology, Biosciences Center, Federal University of Rio Grande do Norte, Natal 59064-741, RN, Brazil
Interests: infectious disease prophylaxis and immune response against infectious diseases

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Guest Editor
Oswaldo Cruz Foundation/Fiocruz, Aggeu Magalhães Institute, Recife 50740-465, Brazil
Interests: chikungunya; dengue virus; pathogenesis; positive-strand RNA zika virus; alphaviruses
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Special Issue Information

Dear Colleagues,

Arthropod-borne viruses (arboviruses) are a group of genetically unrelated single-stranded RNA viruses that infect humans and animals. They pose a significant global health threat, causing diseases such as Zika, Dengue, Chikungunya, Yellow fever, and others. Mediators of innate and adaptive immune responses participate in the process of resistance to viral infection but can also contribute to the pathogenesis process. Understanding the intricate interplay between the innate and adaptive immune responses to arbovirus as well as associated comorbidity factors is paramount for developing effective preventive and therapeutic strategies to combat these emerging and re-emerging infectious diseases.

The goal of this Special Issue is to provide an up-to-date view of the multifaceted aspects of the immune system's response to arboviruses in human, experimental models, and naturally-infected animals. New insights are welcome. Topics of interest include, but are not limited to the following:

  • The role of pattern recognition receptors and the subsequent induction of antiviral pathways;
  • Generation of virus-specific antibodies and their function in subsequent infection;
  • T cell responses against arbovirus;
  • Memory induction and maintenance;
  • Response to congenital arbovirus infection;
  • Prevalence and influence of comorbidities on immune responses to arboviruses;
  • Immunotherapeutic approaches;
  • Vaccines;
  • Immune evasion mechanisms employed by the arboviruses.

Dr. Manuela Sales Lima Nascimento
Dr. Paulo Marcos da Matta Guedes
Dr. Rafael Freitas de Oliveira França
Guest Editors

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Keywords

  • arbovirus
  • innate immunity
  • adaptive immunity
  • immunotherapeutic
  • immunoprophylaxis
  • vaccines

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Published Papers (1 paper)

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Review

15 pages, 1698 KiB  
Review
Immuno-Haematologic Aspects of Dengue Infection: Biologic Insights and Clinical Implications
by Tan Jiao Jie Cherie, Clarice Shi Hui Choong, Muhammad Bilal Abid, Matthew W. Weber, Eng Soo Yap, Suranjith L. Seneviratne, Visula Abeysuriya and Sanjay de Mel
Viruses 2024, 16(7), 1090; https://doi.org/10.3390/v16071090 - 6 Jul 2024
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Abstract
Dengue infection is caused by the dengue virus (DENV) and is transmitted to humans by infected female Aedes aegypti and Aedes albopictus mosquitoes. There are nearly 100 million new dengue cases yearly in more than 120 countries, with a five-fold increase in incidence [...] Read more.
Dengue infection is caused by the dengue virus (DENV) and is transmitted to humans by infected female Aedes aegypti and Aedes albopictus mosquitoes. There are nearly 100 million new dengue cases yearly in more than 120 countries, with a five-fold increase in incidence over the past four decades. While many patients experience a mild illness, a subset suffer from severe disease, which can be fatal. Dysregulated immune responses are central to the pathogenesis of dengue, and haematologic manifestations are a prominent feature of severe disease. While thrombocytopaenia and coagulopathy are major causes of bleeding in severe dengue, leucocyte abnormalities are emerging as important markers of prognosis. In this review, we provide our perspective on the clinical aspects and pathophysiology of haematologic manifestations in dengue. We also discuss the key gaps in our current practice and areas to be addressed by future research. Full article
(This article belongs to the Special Issue Innate and Adaptive Immune Responses to Arbovirus Infections)
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