Innate and Adaptive Immune Responses to Arbovirus Infections

Dear Colleagues,

Arthropod-borne viruses (arboviruses) are a group of genetically unrelated single-stranded RNA viruses that infect humans and animals. They pose a significant global health threat, causing diseases such as Zika, Dengue, Chikungunya, Yellow fever, and others. Mediators of innate and adaptive immune responses participate in the process of resistance to viral infection but can also contribute to the pathogenesis process. Understanding the intricate interplay between the innate and adaptive immune responses to arbovirus as well as associated comorbidity factors is paramount for developing effective preventive and therapeutic strategies to combat these emerging and re-emerging infectious diseases.

The goal of this Special Issue is to provide an up-to-date view of the multifaceted aspects of the immune system's response to arboviruses in human, experimental models, and naturally-infected animals. New insights are welcome. Topics of interest include, but are not limited to the following:

• The role of pattern recognition receptors and the subsequent induction of antiviral pathways;
• Generation of virus-specific antibodies and their function in subsequent infection;
• T cell responses against arbovirus;
• Memory induction and maintenance;
• Response to congenital arbovirus infection;
• Prevalence and influence of comorbidities on immune responses to arboviruses;
• Immunotherapeutic approaches;
• Vaccines;
• Immune evasion mechanisms employed by the arboviruses.

Dr. Manuela Sales Lima Nascimento
Dr. Paulo Marcos da Matta Guedes
Dr. Rafael Freitas de Oliveira França
Guest Editors

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• arbovirus
• innate immunity
• adaptive immunity
• immunotherapeutic
• immunoprophylaxis
• vaccines